Identification of a sequence of human activated protein C (residues 390-404) essential for its anticoagulant activity

scientific article published on December 25, 1991

Identification of a sequence of human activated protein C (residues 390-404) essential for its anticoagulant activity is …
instance of (P31):
scholarly articleQ13442814

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P953full work available at URLhttp://intl.jbc.org/cgi/content/abstract/266/36/24514
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P698PubMed publication ID1761551

P2093author name stringJ. H. Griffin
R. A. Houghten
R. M. Mesters
P2860cites workCharacterization of a cDNA coding for human factor XQ24595573
Deficiency of protein C in congenital thrombotic diseaseQ24600822
General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acidsQ24612820
The structure and evolution of a 461 amino acid human protein C precursor and its messenger RNA, based upon the DNA sequence of cloned human liver cDNAsQ24626095
THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONSQ26778400
A comprehensive set of sequence analysis programs for the VAXQ26778432
A comparison of human prothrombin, factor IX (Christmas factor), factor X (Stuart factor), and protein SQ28262397
Characterization of a cDNA coding for human factor VIIQ28646329
Anticoagulant properties of bovine plasma protein C following activation by thrombinQ34241254
Molecular cloning of the gene for human anti-haemophilic factor IX.Q34253608
Preparation and properties of bovine factor VIII (antihemophilic factor).Q34285283
Topographical localization of the C-terminal region of the voltage-dependent sodium channel from Electrophorus electricus using antibodies raised against a synthetic peptideQ34587067
Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C.Q35345503
Evolution and organization of the human protein C geneQ35587591
Characterization of the complementary deoxyribonucleic acid and gene coding for human prothrombinQ36597580
Human plasma protein C: isolation, characterization, and mechanism of activation by alpha-thrombinQ37041393
Intrinsic and extrinsic factors in protein antigenic structureQ38151120
The physical basis for induction of protein-reactive antipeptide antibodiesQ38190293
Location of disulphide bridges by diagonal paper electrophoresis. The disulphide bridges of bovine chymotrypsinogen A.Q39254503
Vitamin K-Dependent Formation of γ-Carboxyglutamic AcidQ39687153
Molar absorptivity and A1 percent 1cm values for proteins at selected wavelengths of the ultraviolet and visible regions. IX.Q39934344
The evolutionary relationship of the enzymes involved in blood coagulation and hemostasisQ42077532
Comparative modeling methods: application to the family of the mammalian serine proteasesQ43524110
Mutations in the catalytic domain of human coagulation factor IX: rapid characterization by direct genomic sequencing of DNA fragments displaying an altered melting behaviorQ45884668
Inherited protein C deficiency and coumarin-responsive chronic relapsing purpura fulminans in a newborn infantQ59418581
The inhibition of blood coagulation by activated protein C through the selective inactivation of activated factor VQ66971115
Interaction of vitamin K dependent proteins with membranesQ67015739
Immunoblotting studies of the molecular forms of protein C in plasmaQ67985678
Proteolytic formation and properties of a fragment of protein C containing the gamma-carboxyglutamic acid rich domain and the EGF-like regionQ68780218
Comparison of four bifunctional reagents for coupling peptides to proteins and the effect of the three moieties on the immunogenicity of the conjugatesQ69205718
A fatal thrombotic disorder associated with an acquired inhibitor of protein CQ69453345
One-step procedure for the rapid isolation of mouse monoclonal antibodies and their antigen binding fragments by fast protein liquid chromatography on a mono Q anion-exchange columnQ70060990
Comparative model-building of the mammalian serine proteasesQ70240611
Homozygous protein C deficiency manifested by massive venous thrombosis in the newbornQ70811173
p-Nitrophenyl-p'-guanidinobenzoate HCl: a new active site titrant for trypsinQ82640878
P433issue36
P407language of work or nameEnglishQ1860
P921main subjectbiochemistryQ7094
cell biologyQ7141
blood coagulationQ179217
anticoagulantQ215118
drotrecogin alfaQ412888
anticoagulationQ63279445
P1104number of pages6
P304page(s)24514-24519
P577publication date1991-12-01
1991-12-25
P1433published inJournal of Biological ChemistryQ867727
P1476titleIdentification of a sequence of human activated protein C (residues 390-404) essential for its anticoagulant activity
P478volume266

Reverse relations

cites work (P2860)
Q36280112Binding sites for blood coagulation factor Xa and protein S involving residues 493-506 in factor Va.
Q39026107Detailed mechanisms of the inactivation of factor VIIIa by activated protein C in the presence of its cofactors, protein S and factor V.
Q41771533Factor V is an anticoagulant cofactor for activated protein C during inactivation of factor Va.
Q41786857Function of the activated protein C (APC) autolysis loop in activated FVIII inactivation
Q45827359Identification of protein C epitopes altered during its nanoencapsulation
Q50924464Improved coagulation and haemostasis in haemophilia with inhibitors by combinations of superFactor Va and Factor VIIa.
Q34165592Improved hemostasis in hemophilia mice by means of an engineered factor Va mutant
Q36278184Interactions and inhibition of blood coagulation factor Va involving residues 311-325 of activated protein C.
Q38269759Interdomain engineered disulfide bond permitting elucidation of mechanisms of inactivation of coagulation factor Va by activated protein C
Q36278723Models of the serine protease domain of the human antithrombotic plasma factor activated protein C and its zymogen
Q41142483Nonenzymatic anticoagulant activity of the mutant serine protease Ser360Ala-activated protein C mediated by factor Va
Q36863328Safety, Stability and Pharmacokinetic Properties of (super)Factor Va, a Novel Engineered Coagulation Factor V for Treatment of Severe Bleeding.
Q27734660The 2.8 A crystal structure of Gla-domainless activated protein C

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