Meropenem-Vaborbactam Resistance Selection, Resistance Prevention, and Molecular Mechanisms in Mutants of KPC-Producing Klebsiella pneumoniae

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Meropenem-Vaborbactam Resistance Selection, Resistance Prevention, and Molecular Mechanisms in Mutants of KPC-Producing Klebsiella pneumoniae is …
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scholarly articleQ13442814

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P356DOI10.1128/AAC.01694-17
P8608Fatcat IDrelease_bhdwbgssirctnl5rhiiw6h7qjm
P932PMC publication ID5700310
P698PubMed publication ID29038260

P2093author name stringMichael N Dudley
Dongxu Sun
Olga Lomovskaya
Debora Rubio-Aparicio
Kirk Nelson
P2860cites workEmergence of Ceftazidime-Avibactam Resistance Due to Plasmid-Borne blaKPC-3 Mutations during Treatment of Carbapenem-Resistant Klebsiella pneumoniae InfectionsQ40392497
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Vaborbactam: Spectrum of Beta-Lactamase Inhibition and Impact of Resistance Mechanisms on Activity in EnterobacteriaceaeQ42638031
Resistance to Ceftazidime-Avibactam in Klebsiella pneumoniae Due to Porin Mutations and the Increased Expression of KPC-3.Q45199771
Activity of biapenem (RPX2003) combined with the boronate β-lactamase inhibitor RPX7009 against carbapenem-resistant EnterobacteriaceaeQ45565740
Meropenem-Vaborbactam Tested against Contemporary Gram-Negative Isolates Collected Worldwide during 2014, Including Carbapenem-Resistant, KPC-Producing, Multidrug-Resistant, and Extensively Drug-Resistant Enterobacteriaceae.Q53735018
SPAdes: a new genome assembly algorithm and its applications to single-cell sequencingQ24629733
Carbapenemase-producing Klebsiella pneumoniae: molecular and genetic decodingQ27013922
Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine CarbapenemasesQ27698519
Prokka: rapid prokaryotic genome annotationQ29616643
Contribution of OmpK36 to carbapenem susceptibility in KPC-producing Klebsiella pneumoniaeQ33474709
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Carbapenem resistance in Enterobacteriaceae: here is the storm!Q34266306
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Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of the β-Lactamase Inhibitor Vaborbactam (RPX7009) in Healthy Adult SubjectsQ34537388
Klebsiella pneumoniae outer membrane porins OmpK35 and OmpK36 play roles in both antimicrobial resistance and virulenceQ34737663
Doripenem MICs and ompK36 porin genotypes of sequence type 258, KPC-producing Klebsiella pneumoniae may predict responses to carbapenem-colistin combination therapy among patients with bacteremia.Q35076943
Tigecycline susceptibility and the role of efflux pumps in tigecycline resistance in KPC-producing Klebsiella pneumoniae.Q35570710
Klebsiella pneumoniae ST258 producing KPC-3 identified in italy carries novel plasmids and OmpK36/OmpK35 porin variantsQ35867410
In vitro selection of ceftazidime-avibactam resistance in Enterobacteriaceae with KPC-3 carbapenemaseQ35960745
Effects of Klebsiella pneumoniae carbapenemase subtypes, extended-spectrum β-lactamases, and porin mutations on the in vitro activity of ceftazidime-avibactam against carbapenem-resistant K. pneumoniaeQ35960957
Regulation of transcription of the repA1 gene in the replication control region of IncFII plasmid NR1 by gene dosage of the repA2 transcription repressor proteinQ36290313
Meropenem-RPX7009 Concentrations in Plasma, Epithelial Lining Fluid, and Alveolar Macrophages of Healthy Adult SubjectsQ36290773
Carbapenemases in Klebsiella pneumoniae and other Enterobacteriaceae: an evolving crisis of global dimensionsQ36361921
Role of the Outer Membrane and Porins in Susceptibility of β-Lactamase-Producing Enterobacteriaceae to Ceftazidime-AvibactamQ36644679
Structure, Function and Regulation of Outer Membrane Proteins Involved in Drug Transport in Enterobactericeae: the OmpF/C - TolC CaseQ36743082
Effect of the β-Lactamase Inhibitor Vaborbactam Combined with Meropenem against Serine Carbapenemase-Producing EnterobacteriaceaeQ37203731
Pharmacokinetic and pharmacodynamic properties of meropenemQ37247125
Mutations of the ompK36 porin gene and promoter impact responses of sequence type 258, KPC-2-producing Klebsiella pneumoniae strains to doripenem and doripenem-colistin.Q37263324
Multi-institute analysis of carbapenem resistance reveals remarkable diversity, unexplained mechanisms, and limited clonal outbreaksQ37626179
Functional characterization of Tn4401, a Tn3-based transposon involved in blaKPC gene mobilizationQ38726335
Occurrence of carbapenemase-producing Klebsiella pneumoniae and Escherichia coli in the European survey of carbapenemase-producing Enterobacteriaceae (EuSCAPE): a prospective, multinational studyQ39170725
High ceftazidime hydrolysis activity and porin OmpK35 deficiency contribute to the decreased susceptibility to ceftazidime/avibactam in KPC-producing Klebsiella pneumoniaeQ40282001
Activity of Meropenem Combined with RPX7009, a Novel β-Lactamase Inhibitor, against Gram-Negative Clinical Isolates in New York CityQ40284963
Multicenter Clinical and Molecular Epidemiological Analysis of Bacteremia Due to Carbapenem-Resistant Enterobacteriaceae (CRE) in the CRE Epicenter of the United StatesQ40342728
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectKlebsiella pneumoniaeQ132592
P577publication date2017-10-16
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleMeropenem-Vaborbactam Resistance Selection, Resistance Prevention, and Molecular Mechanisms in Mutants of KPC-Producing Klebsiella pneumoniae
P478volume61

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cites work (P2860)
Q92452234Activity of Meropenem-Vaborbactam against Bacterial Isolates Causing Pneumonia in Patients in U.S. Hospitals during 2014 to 2018
Q92441701Antibiotic resistance breakers: current approaches and future directions
Q92690711Avibactam Sensitizes Carbapenem-Resistant NDM-1-Producing Klebsiella pneumoniae to Innate Immune Clearance
Q91825577Defining the Role of Novel β-Lactam Agents That Target Carbapenem-Resistant Gram-Negative Organisms
Q96136650How to manage KPC infections
Q90712005Meropenem-Vaborbactam as Salvage Therapy for Ceftazidime-Avibactam-Resistant Klebsiella pneumoniae Bacteremia and Abscess in a Liver Transplant Recipient
Q88417556Meropenem-vaborbactam: a carbapenem and beta-lactamase inhibitor with activity against carbapenem-resistant Enterobacteriaceae
Q52564980Meropenem-vaborbactam: a new weapon in the war against infections due to resistant  Gram-negative bacteria.
Q89864907Meropenem/Vaborbactam versus Ceftazidime/Avibactam for Treatment of Carbapenem-Resistant Enterobacteriaceae Infections
Q58733616Meropenem/Vaborbactam: A Review in Complicated Urinary Tract Infections
Q58746821Overview of meropenem-vaborbactam and newer antimicrobial agents for the treatment of carbapenem-resistant
Q57036779Pathogen-Specific Clinical Trials: A New Paradigm in Clinical Trials for Multidrug-Resistant Organisms
Q89517185Potency of Vaborbactam Is Less Affected than That of Avibactam in Strains Producing KPC-2 Mutations That Confer Resistance to Ceftazidime-Avibactam
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