Monoacylglycerol signalling and ABHD6 in health and disease.

scientific article

Monoacylglycerol signalling and ABHD6 in health and disease. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1111/DOM.13008
P698PubMed publication ID28880480

P50authorPegah PoursharifiQ51318805
Sri Ramachandra Murthy MadirajuQ88929302
P2093author name stringMarc Prentki
P2860cites workBiochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12)Q24298516
Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brainQ24299523
Brain monoglyceride lipase participating in endocannabinoid inactivationQ24533828
The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptorsQ24602845
The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptorsQ24617322
Activity-based proteomics of enzyme superfamilies: serine hydrolases as a case studyQ24634117
A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerolQ24649418
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Brown and Beige Fat: Molecular Parts of a Thermogenic MachineQ28082723
Lipid phosphate phosphatases and their roles in mammalian physiology and pathologyQ28088430
α/β-Hydrolase domain-6 and saturated long chain monoacylglycerol regulate insulin secretion promoted by both fuel and non-fuel stimuli.Q41769019
Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferasesQ41818160
Simplified assays of lipolysis enzymes for drug discovery and specificity assessment of known inhibitors.Q41906728
Porcupine Controls Hippocampal AMPAR Levels, Composition, and Synaptic TransmissionQ41942876
Blockade of monoacylglycerol lipase inhibits oligodendrocyte excitotoxicity and prevents demyelination in vivo.Q42464099
Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellumQ42494226
Targeting triglyceride/fatty acid cycling in β-cells as a therapy for augmenting glucose-stimulated insulin secretionQ42794164
α/β-Hydrolase Domain 6 Deletion Induces Adipose Browning and Prevents Obesity and Type 2 Diabetes.Q42812581
Increasing levels of the endocannabinoid 2-AG is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's diseaseQ43162071
In vitro stereoselective hydrolysis of diacylglycerols by hormone-sensitive lipase.Q43267747
Isolation of lysophosphatidic acid phosphatase from developing peanut cotyledons.Q43916209
Cannabinoids ablate release of TNFalpha in rat microglial cells stimulated with lypopolysaccharideQ44267931
2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces accelerated production of chemokines in HL-60 cellsQ44872391
Intramolecular occlusion of the diacylglycerol-binding site in the C1 domain of munc13-1.Q45235934
Fatty acid amide hydrolase but not monoacyl glycerol lipase controls cell death induced by the endocannabinoid 2-arachidonoyl glycerol in hepatic cell populationsQ45282573
PXK locus in systemic lupus erythematosus: fine mapping and functional analysis reveals novel susceptibility gene ABHD6.Q46023783
A functional proteomic strategy to discover inhibitors for uncharacterized hydrolasesQ46044614
A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide releaseQ46665845
Evaluation of the 'side door' in carboxylesterase-mediated catalysis and inhibitionQ46829757
Expression and function of monoacylglycerol lipase in mouse β-cells and human islets of LangerhansQ47445877
Munc13-1 deficiency reduces insulin secretion and causes abnormal glucose toleranceQ48563863
Discovery of glycine sulfonamides as dual inhibitors of sn-1-diacylglycerol lipase α and α/β-hydrolase domain 6.Q48681871
Activation of CB2 receptor is required for the therapeutic effect of ABHD6 inhibition in experimental autoimmune encephalomyelitis.Q50953458
Enzymes catalyzing the hydrolysis of long-chain monoacyglycerols in rat adipose tissueQ51664193
Stereoselective hydrolysis of triglycerides by animal and microbial lipasesQ56625602
Intestinal Monoacylglycerol MetabolismQ57843934
Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cellsQ58088431
From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex PharmacologyQ38821074
Role of lipids in the metabolism and activation of immune cellsQ38899326
Transient Receptor Potential Channels in neuropathic painQ39005452
High expression of the evolutionarily conserved alpha/beta hydrolase domain containing 6 (ABHD6) in Ewing tumorsQ39793314
Monoacylglycerols activate capsaicin receptor, TRPV1.Q39982192
Regulation, function, and dysregulation of endocannabinoids in models of adipose and beta-pancreatic cells and in obesity and hyperglycemiaQ40282032
α/β Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal/Lysosomal Lipid Bis(monoacylglycero)phosphateQ40404245
α/β-Hydrolase Domain 6 in the Ventromedial Hypothalamus Controls Energy Metabolism Flexibility.Q40514195
Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes.Q40525710
Effects of cannabinoids on LPS-stimulated inflammatory mediator release from macrophages: involvement of eicosanoids.Q40809261
2-Arachidonylglycerol, an endogenous cannabinoid, inhibits tumor necrosis factor-alpha production in murine macrophages, and in miceQ40852080
Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptorsQ41700452
Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesteroneQ28118748
2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humansQ28243838
cDNA cloning, tissue distribution, and identification of the catalytic triad of monoglyceride lipase. Evolutionary relationship to esterases, lysophospholipases, and haloperoxidasesQ28252158
2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brainQ28290395
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptorsQ28292914
Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agentsQ28300398
The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndromeQ28504726
ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARCQ28509608
Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptorQ28509942
Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolismQ28512146
Monoacylglycerols activate TRPV1--a link between phospholipase C and TRPV1Q28535638
Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid systemQ28590486
The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipaseQ28591427
The cloned capsaicin receptor integrates multiple pain-producing stimuliQ29547511
PPARs and the complex journey to obesityQ29619271
Adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) deficiencies affect expression of lipolytic activities in mouse adipose tissuesQ30529628
Oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins by cyclooxygenase-2.Q30606134
Inactivation of lipid glyceryl ester metabolism in human THP1 monocytes/macrophages by activated organophosphorus insecticides: role of carboxylesterases 1 and 2Q30981876
Fat poetry: a kingdom for PPAR gammaQ33437489
Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screeningQ33749260
Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesisQ33914549
Demonstration of an intestinal monoglyceride lipase: an enzyme with a possible role in the intracellular completion of fat digestionQ33943103
ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 miceQ34060224
2-Arachidonoylglycerol and the cannabinoid receptorsQ34098975
Biosynthesis and degradation of the endocannabinoid 2-arachidonoylglycerolQ34165188
Prostaglandins and inflammationQ34179727
The membrane fusion enigma: SNAREs, Sec1/Munc18 proteins, and their accomplices--guilty as charged?Q34305507
Fat mobilization in adipose tissue is promoted by adipose triglyceride lipaseQ34369246
Brown and beige fat: development, function and therapeutic potentialQ34375850
An unannotated alpha/beta hydrolase superfamily member, ABHD6 differentially expressed among cancer cell linesQ34764248
Physiological roles of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligandQ34968661
Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance.Q34978868
Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplayQ34995628
Cellular target genes of Epstein-Barr virus nuclear antigen 2.Q35101342
Monoacylglycerol lipase exerts dual control over endocannabinoid and fatty acid pathways to support prostate cancerQ35146525
The metabolic serine hydrolases and their functions in mammalian physiology and diseaseQ35333042
The digestion of dietary triacylglycerols.Q35599797
Peroxisome proliferator-activated receptor α (PPARα) induces PPARγ coactivator 1α (PGC-1α) gene expression and contributes to thermogenic activation of brown fat: involvement of PRDM16.Q35604665
Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors.Q35753542
Mechanisms of lysophosphatidic acid productionQ35844014
G protein-coupled receptors and insulin secretion: 119 and countingQ35867521
Evidence for regulated monoacylglycerol acyltransferase expression and activity in human liver.Q35897072
Inhibition of Monoacylglycerol Lipase Activity Decreases Glucose-Stimulated Insulin Secretion in INS-1 (832/13) Cells and Rat IsletsQ35920878
Obesity, metabolic syndrome, and type 2 diabetes: emerging epidemics and their cardiovascular implicationsQ35926379
Characterization of the Mouse and Human Monoacylglycerol O-Acyltransferase 1 (Mogat1) Promoter in Human Kidney Proximal Tubule and Rat Liver CellsQ36128458
An in vivo multiplexed small-molecule screening platformQ36129729
DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responsesQ36443943
Mammalian alpha beta hydrolase domain (ABHD) proteins: Lipid metabolizing enzymes at the interface of cell signaling and energy metabolismQ36612260
Biochemistry and pathophysiology of intravascular and intracellular lipolysisQ36708030
Selective inhibition of alpha/beta-hydrolase domain 6 attenuates neurodegeneration, alleviates blood brain barrier breakdown, and improves functional recovery in a mouse model of traumatic brain injuryQ36795890
α/β-Hydrolase domain-containing 6 (ABHD6) negatively regulates the surface delivery and synaptic function of AMPA receptorsQ36905084
Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: Location, hydrolysis and 12-lipoxygenase metabolism.Q36932469
Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6.Q37256080
Lipid mediators in health and disease: enzymes and receptors as therapeutic targets for the regulation of immunity and inflammationQ37286185
Glycerol-3-phosphate acyltransferases: rate limiting enzymes of triacylglycerol biosynthesisQ37332722
The Role of PPARs in the Endothelium: Implications for Cancer TherapyQ37337997
What we talk about when we talk about fat.Q37601812
Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6)Q37704738
A review on the monoacylglycerol lipase: at the interface between fat and endocannabinoid signalling.Q37758870
Glycerolipid/free fatty acid cycle and islet β-cell function in health, obesity and diabetesQ37959707
GPR119 as a fat sensorQ38007638
Metabolic signaling in fuel-induced insulin secretionQ38116234
Adipose tissue browning and metabolic healthQ38154504
Open questions in lipid droplet biology.Q38163178
Brown fat fuel utilization and thermogenesisQ38175686
FAT FLUX: enzymes, regulators, and pathophysiology of intracellular lipolysisQ38325443
Systemic transcriptome analysis of hepatocellular carcinomaQ38755671
Oral 2-oleyl glyceryl ether improves glucose tolerance in mice through the GPR119 receptor.Q38764638
P304page(s)76-89
P577publication date2017-09-01
P1433published inDiabetes, Obesity and MetabolismQ5270109
P1476titleMonoacylglycerol signalling and ABHD6 in health and disease
P478volume19 Suppl 1

Reverse relations

cites work (P2860)
Q92210185A Preliminary Investigation towards the Risk Stratification of Allogeneic Stem Cell Recipients with Respect to the Potential for Development of GVHD via Their Pre-Transplant Plasma Lipid and Metabolic Signature
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Q90823333The role of metabolic lipases in the pathogenesis and management of liver disease

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