Organ-specific protection mediated by cooperation between vascular and epithelial barriers.

scientific article

Organ-specific protection mediated by cooperation between vascular and epithelial barriers. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/NRI.2017.100
P698PubMed publication ID28869253

P50authorGiulia FornasaQ58924256
P2093author name stringMaria Rescigno
Ilaria Spadoni
P2860cites workPericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain AgingQ24600644
Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestineQ24609125
Pericytes are required for blood-brain barrier integrity during embryogenesisQ24627396
CNS immune privilege: hiding in plain sightQ24642697
Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesisQ24681191
Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disordersQ26777279
Sleep and gastrointestinal disturbances in autism spectrum disorder in childrenQ26783381
Role of gut microbiota in the modulation of atherosclerosis-associated immune responseQ26801649
Development and functions of the choroid plexus-cerebrospinal fluid systemQ26801821
Retinoic acid induces blood-brain barrier development.Q39205654
Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases.Q39275409
The predominant site of bacterial translocation across the intestinal mucosal barrier occurs at the advancing disease margin in Crohn's diseaseQ39600588
Recruitment of pericytes and astrocytes is closely related to the formation of tight junction in developing retinal vesselsQ39935875
Gene expression profile of endothelial cells during perturbation of the gut vascular barrier.Q40471016
Effect of short-chain fatty acids on paracellular permeability in Caco-2 intestinal epithelium modelQ41118303
Characterization of suppressor cells in anterior chamber-associated immune deviation (ACAID) induced by soluble antigen. Evidence of two functionally and phenotypically distinct T-suppressor cell populationsQ41138099
Identification of transforming growth factor-beta as an immunosuppressive factor in aqueous humor.Q41675605
Mesenteric lymph nodes at the center of immune anatomyQ42108522
Origin of the lamina propria dendritic cell networkQ42117974
Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions.Q42138485
The liver may act as a firewall mediating mutualism between the host and its gut commensal microbiotaQ42214432
Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction.Q43081763
Diabetes and hypercholesterolemia increase blood-brain barrier permeability and brain amyloid deposition: beneficial effects of the LpPLA2 inhibitor darapladibQ44980018
Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cells.Q45943518
Colonic inflammation in Parkinson's disease.Q46015750
Intestinal epithelial cells promote colitis-protective regulatory T-cell differentiation through dendritic cell conditioning.Q46040098
Early retinal and renal abnormalities in diabetesQ46075141
The somnogenic T lymphocyte suppressor prostaglandin D2 is selectively elevated in cerebrospinal fluid of advanced sleeping sickness patients.Q46794773
Development, maintenance and disruption of the blood-brain barrierQ26829668
Oral tolerance to food proteinQ27026259
Obese-type gut microbiota induce neurobehavioral changes in the absence of obesityQ27329095
Size-selective loosening of the blood-brain barrier in claudin-5-deficient miceQ28203769
T cell exclusion, immune privilege, and the tumor microenvironmentQ28259872
Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthoodQ28292031
Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124.Q28507603
GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrierQ28509184
Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculatureQ28509331
Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesisQ28594356
Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdownQ28817495
Ecological and evolutionary forces shaping microbial diversity in the human intestineQ29547586
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanismQ29614266
Molecular analysis of commensal host-microbial relationships in the intestineQ29614776
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acidQ29615586
Pericytes regulate the blood-brain barrierQ29615840
Normal gut microbiota modulates brain development and behaviorQ29616855
Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disordersQ29617111
Bifidobacteria can protect from enteropathogenic infection through production of acetateQ29617592
Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitisQ29619978
Revisiting the Mechanisms of CNS Immune PrivilegeQ30278584
Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cellsQ30476839
Interleukin-25 expressed by brain capillary endothelial cells maintains blood-brain barrier function in a protein kinase Cepsilon-dependent mannerQ33553749
Conditional Müllercell ablation causes independent neuronal and vascular pathologies in a novel transgenic modelQ33581991
Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.Q33717326
The treatment-naive microbiome in new-onset Crohn's diseaseQ33762817
Comparison of sensitivity of Th1, Th2, and Th17 cells to Fas-mediated apoptosisQ33859990
Enterocolitis induced by autoimmune targeting of enteric glial cells: a possible mechanism in Crohn's disease?Q33949335
Anatomical basis of tolerance and immunity to intestinal antigensQ33965210
Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivoQ34049368
Developing nervous tissue induces formation of blood-brain barrier characteristics in invading endothelial cells: a study using quail--chick transplantation chimerasQ34057185
The development of blood-retinal barrier during the interaction of astrocytes with vascular wall cellsQ34096257
The retinal pigment epithelium: something more than a constituent of the blood-retinal barrier--implications for the pathogenesis of diabetic retinopathy.Q34100527
Multiple facets of intestinal permeability and epithelial handling of dietary antigensQ34110996
SSeCKS regulates angiogenesis and tight junction formation in blood-brain barrierQ34206194
Epithelial barrier: an interface for the cross-communication between gut flora and immune systemQ34240555
Celiac disease and its link to type 1 diabetes mellitus.Q34274386
Orchestrated leukocyte recruitment to immune-privileged sites: absolute barriers versus educational gatesQ48151397
Rejection of fetal neocortical neural transplants by H-2 incompatible miceQ48201567
Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathioneQ48217613
Gradual Suppression of Transcytosis Governs Functional Blood-Retinal Barrier FormationQ48249430
The role of Müller cells in the formation of the blood-retinal barrierQ48257006
Retinal pathology is associated with increased blood-retina barrier permeability in a diabetic and hypercholesterolaemic pig model: Beneficial effects of the LpPLA2 inhibitor Darapladib.Q48260488
The fate of allogeneic and xenogeneic neuronal tissue transplanted into the third ventricle of rodentsQ48278859
CXCL12 limits inflammation by localizing mononuclear infiltrates to the perivascular space during experimental autoimmune encephalomyelitisQ48365016
ApoE deficiency leads to a progressive age-dependent blood-brain barrier leakageQ48461941
Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic miceQ48479409
The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescenceQ48797548
Claudin-1, claudin-2 and claudin-11 are present in tight junctions of choroid plexus epithelium of the mouseQ48828901
Brain endothelium lack one of two pathways of P-selectin-mediated neutrophil adhesion.Q48829755
Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis.Q49014751
Alpha-synuclein in colonic submucosa in early untreated Parkinson's diseaseQ49037483
Inhibition of antigen-stimulated effector T cells by human cerebrospinal fluidQ49068413
Decreased levels of intrathecal interleukin 1 receptor antagonist in Alzheimer's diseaseQ49245290
Alterations of the intestinal barrier in patients with autism spectrum disorders and in their first-degree relatives.Q50302739
Evaluation of Intestinal Function in Children With Autism and Gastrointestinal SymptomsQ50306071
Impaired brain angiogenesis and neuronal apoptosis induced by conditional homozygous inactivation of vascular endothelial growth factor.Q51019927
Astrocytes induce blood–brain barrier properties in endothelial cellsQ57318253
Increased intestinal permeability precedes clinical onset of type 1 diabetesQ79211266
Retinal and ciliary body pigment epithelium suppress activation of T lymphocytes via transforming growth factor betaQ80332034
Oral tolerance can be established via gap junction transfer of fed antigens from CX3CR1⁺ macrophages to CD103⁺ dendritic cellsQ87163156
Blood-retinal barrier in hypoxic ischaemic conditions: basic concepts, clinical features and managementQ37304800
Perivascular spaces and the two steps to neuroinflammationQ37329042
Immune privilege or privileged immunity?Q37349741
Incidence of gastrointestinal symptoms in children with autism: a population-based studyQ37353825
Tissue factor and PAR1 promote microbiota-induced intestinal vascular remodellingQ37451950
Blood-brain barrier and intestinal epithelial barrier alterations in autism spectrum disordersQ37456857
The gut immune barrier and the blood-brain barrier: are they so different?Q37616357
Immune privilege of the CNS is not the consequence of limited antigen samplingQ37653497
Capture, crawl, cross: the T cell code to breach the blood-brain barriersQ38038445
Postbiotics: what else?Q38070062
Extraintestinal manifestations and complications in IBD.Q38120146
Barrier properties of cultured retinal pigment epitheliumQ38204565
The choroid plexuses and their impact on developmental neurogenesisQ38266875
Intestinal mucosal tolerance and impact of gut microbiota to mucosal toleranceQ38335183
Claudin-1, -2 and -3 Are Selectively Expressed in the Epithelia of the Choroid Plexus of the Mouse from Early Development and into Adulthood While Claudin-5 is Restricted to Endothelial CellsQ38582363
Intestinal Dysbiosis, Gut Hyperpermeability and Bacterial Translocation: Missing Links Between Depression, Obesity and Type 2 Diabetes.Q38964759
Gut Microbiota, Bacterial Translocation, and Interactions with Diet: Pathophysiological Links between Major Depressive Disorder and Non-Communicable Medical Comorbidities.Q39018851
The movers and shapers in immune privilege of the CNS.Q39090554
Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum DisorderQ39135788
Gastrointestinal problems in children with autism, developmental delays or typical developmentQ34382693
Central nervous system perivascular cells are immunoregulatory cells that connect the CNS with the peripheral immune systemQ34398632
Pre-eclampsia and pregnancy-induced hypertension are associated with severe diabetic retinopathy in type 1 diabetes later in lifeQ34407459
Host microbiota constantly control maturation and function of microglia in the CNS.Q34478756
Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes and their relatives.Q34518641
Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor.Q34582564
The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune systemQ34798439
Immunological Markers for PML Prediction in MS Patients Treated with NatalizumabQ34818048
Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye.Q34853757
Autistic disorder and gastrointestinal diseaseQ34916579
Microbiota controls the homeostasis of glial cells in the gut lamina propriaQ35013616
Development of the choroid plexus and blood-CSF barrierQ35140713
Human cerebrospinal fluid central memory CD4+ T cells: evidence for trafficking through choroid plexus and meninges via P-selectin.Q35168188
The gut microbiota and developmental programming of the testis in miceQ35223991
Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in ratsQ35313910
The gut microbiota influences blood-brain barrier permeability in miceQ35413892
A review of the influence of aqueous humor on immunityQ35620171
Role of the gastrointestinal ecosystem in the development of type 1 diabetes.Q35624584
Chronic low level complement activation within the eye is controlled by intraocular complement regulatory proteins.Q35750345
A gut-vascular barrier controls the systemic dissemination of bacteria.Q35840463
ApoE deficiency compromises the blood brain barrier especially after injury.Q35944147
The Central Nervous System and the Gut Microbiome.Q36182979
Gut microbiota influences pathological angiogenesis in obesity-driven choroidal neovascularizationQ36196897
Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's DiseaseQ36212145
Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetesQ36323689
Complexity and developmental changes in the expression pattern of claudins at the blood-CSF barrier.Q36353414
See no evil, hear no evil, do no evil: the lessons of immune privilegeQ36426813
Plasmacytoid dendritic cells mediate oral toleranceQ36534744
Ocular autoimmunity: the price of privilege?Q36593726
Immune privilege in the gut: the establishment and maintenance of non-responsiveness to dietary antigens and commensal floraQ36593729
Fecal microbiota composition differs between children with β-cell autoimmunity and those withoutQ36720600
Commensal microbiota is fundamental for the development of inflammatory pain.Q36883155
Wnt/beta-catenin signaling controls development of the blood-brain barrierQ36955697
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectcooperationQ380962
P304page(s)761-773
P577publication date2017-09-04
P1433published inNature Reviews ImmunologyQ43355
P1476titleOrgan-specific protection mediated by cooperation between vascular and epithelial barriers
P478volume17

Reverse relations

cites work (P2860)
Q92876148AAV Vector Immunogenicity in Humans: A Long Journey to Successful Gene Transfer
Q57476572CNS infection and immune privilege
Q89481420CX3CR1+ Macrophages and CD8+ T Cells Control Intestinal IgA Production
Q95642060Dinutuximab Synergistically Enhances the Cytotoxicity of Natural Killer Cells to Retinoblastoma Through the Perforin-Granzyme B Pathway
Q55364545Emerging concepts in non-invasive monitoring of Crohn's disease.
Q96686040Emerging routes to the generation of functional β-cells for diabetes mellitus cell therapy
Q95840390Host-microbiota interactions in immune-mediated diseases
Q92153794How to Make Anticancer Drugs Cross the Blood-Brain Barrier to Treat Brain Metastases
Q90351914IGF-1, Inflammation and Retinal Degeneration: A Close Network
Q89878911Increased Colonic Permeability and Lifestyles as Contributing Factors to Obesity and Liver Steatosis
Q92032230Intestinal microbiome and NAFLD: molecular insights and therapeutic perspectives
Q90205918Intestinal permeability in the pathogenesis of liver damage: From non-alcoholic fatty liver disease to liver transplantation
Q92865404Involvement of the central nervous system in acute lymphoblastic leukemia: opinions on molecular mechanisms and clinical implications based on recent data
Q64123933MMP (Matrix Metalloprotease)-9-Producing Monocytes Enable T Cells to Invade the Vessel Wall and Cause Vasculitis
Q92662501Microbiota-driven gut vascular barrier disruption is a prerequisite for non-alcoholic steatohepatitis development
Q64904804Reprogramming Cells to Make Insulin.
Q55514994The meningeal and choroidal infiltration routes for leukocytes in stroke.
Q92735130The progress of gut microbiome research related to brain disorders
Q48022024Tissue-specific immunopathology during malaria infection
Q89457645Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology

Search more.