Unconventional role of voltage-gated proton channels (VSOP/Hv1) in regulation of microglial ROS production.

scientific article published on 19 June 2017

Unconventional role of voltage-gated proton channels (VSOP/Hv1) in regulation of microglial ROS production. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/JNC.14106
P698PubMed publication ID28628214

P50authorToshihide YamashitaQ50896598
Schuichi KoizumiQ87649618
Takafumi KawaiQ88340181
P2093author name stringYasushi Okamura
Maya Yamazaki
Kenji Sakimura
Manabu Abe
Yoshifumi Okochi
Yoshio Imura
Tomohiko Ozaki
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VSOP/Hv1 proton channels sustain calcium entry, neutrophil migration, and superoxide production by limiting cell depolarization and acidification.Q33615131
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A highly sensitive chemiluminescence assay for superoxide detection and chronic granulomatous disease diagnosisQ35155613
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Microglial Hv1 proton channel promotes cuprizone-induced demyelination through oxidative damageQ36486079
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Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burstQ37160192
Early disruptions of the blood-brain barrier may contribute to exacerbated neuronal damage and prolonged functional recovery following stroke in aged ratsQ37195445
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Characterization of a mutation in the Phox homology domain of the NADPH oxidase component p40phox identifies a mechanism for negative regulation of superoxide productionQ40094185
Continuous Translocation of Rac2 and the NADPH Oxidase Component p67 during PhagocytosisQ40615763
The voltage-gated proton channel Hv1/VSOP inhibits neutrophil granule releaseQ41217119
Microglial K(+) channel expression in young adult and aged mice.Q41620046
Deficiency in the voltage-gated proton channel Hv1 increases M2 polarization of microglia and attenuates brain damage from photothrombotic ischemic stroke.Q41649795
Relationship between phosphorylation and translocation to the plasma membrane of p47phox and p67phox and activation of the NADPH oxidase in normal and Ca(2+)-depleted human neutrophilsQ42085253
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Charge compensation for NADPH oxidase activity in microglia in rat brain slices does not involve a proton current.Q43164978
Protein carbonyl groups as biomarkers of oxidative stress.Q44317892
The voltage dependence of NADPH oxidase reveals why phagocytes need proton channelsQ44389079
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectmicrogliaQ1622829
Voltage-gated Proton ChannelQ67598134
P304page(s)686-699
P577publication date2017-07-20
P1433published inJournal of NeurochemistryQ6295643
P1476titleUnconventional role of voltage-gated proton channels (VSOP/Hv1) in regulation of microglial ROS production
P478volume142

Reverse relations

cites work (P2860)
Q92034704Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations
Q46298977Mechanistic insight into the suppression of microglial ROS production by voltage-gated proton channels (VSOP/Hv1).
Q64963359Molecular mechanisms of coupling to voltage sensors in voltage-evoked cellular signals.
Q47974179Oxidative stress and DNA damage after cerebral ischemia: Potential therapeutic targets to repair the genome and improve stroke recovery

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