IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-alpha and IL-17.

scientific article

IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-alpha and IL-17. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/RHEUMATOLOGY/KEN363
P698PubMed publication ID18786965
P5875ResearchGate publication ID23252039

P2093author name stringN Hayakawa
M Mihara
M Hashizume
P2860cites workJAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expressionQ24316553
RANK is essential for osteoclast and lymph node developmentQ24598872
PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivoQ28609356
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclastsQ29618116
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptorsQ33941380
Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumabQ35954629
Anakinra: review of recombinant human interleukin-I receptor antagonist in the treatment of rheumatoid arthritisQ36095386
RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolismQ37108966
Interleukin-6 receptor shedding is enhanced by interleukin-1beta and tumor necrosis factor alpha and is partially mediated by tumor necrosis factor alpha-converting enzyme in osteoblast-like cells.Q40473293
STAT3 activation in stromal/osteoblastic cells is required for induction of the receptor activator of NF-kappaB ligand and stimulation of osteoclastogenesis by gp130-utilizing cytokines or interleukin-1 but not 1,25-dihydroxyvitamin D3 or parathyroiQ40945774
Signaling mechanisms through gp130: a model of the cytokine systemQ47992455
P433issue11
P921main subjectTNFQ18032037
P304page(s)1635-1640
P577publication date2008-09-11
P1433published inRheumatologyQ7320492
P1476titleIL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-alpha and IL-17.
P478volume47

Reverse relations

cites work (P2860)
Q421109091,25-dihydroxyvitamin D3 inhibits the RANKL pathway and impacts on the production of pathway-associated cytokines in early rheumatoid arthritis
Q36165445A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis
Q34001530A new strategy to deliver synthetic protein drugs: self-reproducible biologics using minicircles
Q37438928A novel T cell cytokine, secreted osteoclastogenic factor of activated T cells, induces osteoclast formation in a RANKL-independent manner
Q42147323A novel intrinsically disordered outer membrane lipoprotein of Aggregatibacter actinomycetemcomitans binds various cytokines and plays a role in biofilm response to interleukin-1β and interleukin-8.
Q87335186A significant induction of neutrophilic chemoattractants but not RANKL in synoviocytes stimulated with interleukin 17
Q49212938Anti-CD11b antibody treatment suppresses the osteoclast generation, inflammatory cell infiltration, and autoantibody production in arthritis-prone FcγRIIB-deficient mice
Q33745638Attenuation of collagen-induced arthritis in mice by salmon proteoglycan
Q104461446Beneficial effects of Vigna angularis extract in osteoporosis and osteoarthritis
Q35614331Bone Loss Triggered by the Cytokine Network in Inflammatory Autoimmune Diseases
Q38593977Bone as a Target Organ in Rheumatic Disease: Impact on Osteoclasts and Osteoblasts
Q58774487Bone erosions in rheumatoid arthritis: recent developments in pathogenesis and therapeutic implications
Q36154208Bone loss in the HIV-infected patient: evidence, clinical implications, and treatment strategies
Q40736447Bone metabolism dysfunction mediated by the increase of proinflammatory cytokines in chronic HIV infection.
Q33563068Bone remodelling markers in rheumatoid arthritis.
Q35092924Bone resorption and remodeling in murine collagenase-induced osteoarthritis after administration of glucosamine
Q37464427Breaking old paradigms: Th17 cells in autoimmune arthritis
Q41825226CCAAT/enhancer-binding protein β promotes receptor activator of nuclear factor-kappa-B ligand (RANKL) expression and osteoclast formation in the synovium in rheumatoid arthritis
Q38115190Can bone loss in rheumatoid arthritis be prevented?
Q39361224Cellular and molecular pathways of structural damage in rheumatoid arthritis
Q54302205Citrullinated vimentin stimulates proliferation, pro-inflammatory cytokine secretion, and PADI4 and RANKL expression of fibroblast-like synoviocytes in rheumatoid arthritis.
Q35003674Clinical significance of interleukin (IL)-6 in cancer metastasis to bone: potential of anti-IL-6 therapies
Q61805448Crataegus Aronia protects and reverses vascular inflammation in a high fat diet rat model by an antioxidant mechanism and modulating serum levels of oxidized low-density lipoprotein
Q37987351Current understanding of rheumatoid arthritis therapy
Q27682535Discovery and characterization of olokizumab
Q52690942Disruption of the mouse Slc39a14 gene encoding zinc transporter ZIP14 is associated with decreased bone mass, likely caused by enhanced bone resorption.
Q50017226Dual neutralization of TNFR-2 and MMP-2 regulates the severity of S. aureus induced septic arthritis correlating alteration in the level of interferon gamma and interleukin-10 in terms of TNFR2 blocking
Q39881401Dual role of interleukin-17 in pannus growth and osteoclastogenesis in rheumatoid arthritis
Q37806615Emerging MRI methods in rheumatoid arthritis
Q37584714Etanercept-Synthesising Mesenchymal Stem Cells Efficiently Ameliorate Collagen-Induced Arthritis
Q38949476F-spondin inhibits differentiation of clastic precursors via lipoprotein receptor-related protein 8 (LRP8).
Q39019996Fibroblasts isolated from a keratocystic odontogenic tumor promote osteoclastogenesis in vitro via interaction with epithelial cells
Q39984572Flesh-eating Streptococcus pyogenes triggers the expression of receptor activator of nuclear factor-κB ligand
Q37783364GP130 cytokines and bone remodelling in health and disease
Q48140227Glucosamine oral administration as an adjunct to hyaluronic acid injection in treating temporomandibular joint osteoarthritis
Q38244166HIV infection, bone metabolism, and fractures.
Q27010898HIV: inflammation and bone
Q53093209IL-33 induces Th17-mediated airway inflammation via mast cells in ovalbumin-challenged mice.
Q34248105IL-6 in inflammation, immunity, and disease
Q30439206IL-6 receptor antagonist as adjunctive therapy with clotting factor replacement to protect against bleeding-induced arthropathy in hemophilia
Q33799161IL-6 secretion in osteoarthritis patients is mediated by chondrocyte-synovial fibroblast cross-talk and is enhanced by obesity
Q53464291IL-6 signal blockade ameliorates the enhanced osteoclastogenesis and the associated joint destruction in a novel FcγRIIB-deficient rheumatoid arthritis mouse model.
Q44261383IL-6 trans-signaling enhances CCL20 production from IL-1β-stimulated human periodontal ligament cells
Q37949664IL-6/IL-6 receptor system and its role in physiological and pathological conditions
Q52647587Identification of sarilumab pharmacodynamic and predictive markers in patients with inadequate response to TNF inhibition: a biomarker substudy of the phase 3 TARGET study.
Q58801220Immunomodulatory drug methotrexate used to treat patients with chronic inflammatory rheumatisms post-chikungunya does not impair the synovial antiviral and bone repair responses
Q37965754Immunotherapeutic implication of IL-6 blockade
Q98177673In vitro IL-6/IL-6R Trans-Signaling in Fibroblasts Releases Cytokines That May Be Linked to the Pathogenesis of IgG4-Related Disease
Q42176661Inhibitory Effect of a Novel Antirheumatic Drug T-614 on the IL-6-Induced RANKL/OPG, IL-17, and MMP-3 Expression in Synovial Fibroblasts from Rheumatoid Arthritis Patients
Q39637547Intercellular adhesion molecule-1 on synovial cells attenuated interleukin-6-induced inhibition of osteoclastogenesis induced by receptor activator for nuclear factor κB ligand
Q40105940Interleukin (IL-6) Immunotherapy
Q39314776Interleukin 17 is a chief orchestrator of immunity
Q41482320Interleukin-15-activated natural killer cells kill autologous osteoclasts via LFA-1, DNAM-1 and TRAIL, and inhibit osteoclast-mediated bone erosion in vitro.
Q53327148Interleukin-29 induces receptor activator of NF-κB ligand expression in fibroblast-like synoviocytes via MAPK signaling pathways.
Q36084929Interleukin-34 produced by human fibroblast-like synovial cells in rheumatoid arthritis supports osteoclastogenesis
Q60916226Interleukin-6 Interweaves the Bone Marrow Microenvironment, Bone Loss, and Multiple Myeloma
Q90117830Interleukin-6 inhibition in the management of non-infectious uveitis and beyond
Q54324742Interleukin-6 upregulates expression of ADAMTS-4 in fibroblast-like synoviocytes from patients with rheumatoid arthritis.
Q48147981Interplay between low plasma RANKL and VDR-FokI polymorphism in lumbar disc herniation independently from age, body mass, and environmental factors: a case-control study in the Italian population.
Q60918210KCa1.1 and Kv1.3 channels regulate the interactions between fibroblast-like synoviocytes and T lymphocytes during rheumatoid arthritis
Q37150420Kinetics and interplay of mediators of inflammation-induced bone damage in the course of adjuvant arthritis
Q42068905Mangiferin suppresses CIA by suppressing the expression of TNF-α, IL-6, IL-1β, and RANKL through inhibiting the activation of NF-κB and ERK1/2.
Q40376112Modeling effects of dexamethasone on disease progression of bone mineral density in collagen-induced arthritic rats
Q37375129Modulatory effect of 1,25-dihydroxyvitamin D 3 on IL1 β -induced RANKL, OPG, TNF α , and IL-6 expression in human rheumatoid synoviocyte MH7A.
Q38601750Muscle Paralysis Induces Bone Marrow Inflammation and Predisposition to Formation of Giant Osteoclasts
Q42938295Non-genomic action of TCDD to induce inflammatory responses in HepG2 human hepatoma cells and in liver of C57BL/6J mice
Q36480992Oral squamous carcinoma cells secrete RANKL directly supporting osteolytic bone loss
Q40235356Osteoclastogenesis induced by CHIKV-infected fibroblast-like synoviocytes: a possible interplay between synoviocytes and monocytes/macrophages in CHIKV-induced arthralgia/arthritis
Q64236844Osteoclasts in the Inflammatory Arthritis: Implications for Pathologic Osteolysis
Q35572441Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infection
Q64079860Osteoimmunology of Bone Loss in Inflammatory Rheumatic Diseases
Q61792382Paracrine-mediated differentiation and activation of human haematopoietic osteoclast precursor cells by skin and gingival fibroblasts
Q89944986Pre-treatment with IL2 gene therapy alleviates Staphylococcus aureus arthritis in mice
Q92067504Predictors of denosumab efficacy in treating osteoporosis in patients with rheumatoid arthritis: a Japanese multicenter study
Q27022976Prevention of colitis-associated cancer: natural compounds that target the IL-6 soluble receptor
Q33692037Prolactin blocks the expression of receptor activator of nuclear factor κB ligand and reduces osteoclastogenesis and bone loss in murine inflammatory arthritis
Q33554023Promising bone-related therapeutic targets for rheumatoid arthritis
Q96298714Pulp stem cells with hepatocyte growth factor overexpression exhibit dual effects in rheumatoid arthritis
Q64096832RANKL is a therapeutic target of bone destruction in rheumatoid arthritis
Q50207113RANKL: A therapeutic target for bone destruction in rheumatoid arthritis
Q37358099Recent advances in neutralizing the IL-6 pathway in arthritis.
Q39495372Reciprocal osteoblastic and osteoclastic modulation in co-cultured MG63 osteosarcoma cells and human osteoclast precursors.
Q54110138Regulatory effect of anti-gp130 functional mAb on IL-6 mediated RANKL and Wnt5a expression through JAK-STAT3 signaling pathway in FLS.
Q36903327Regulatory effect of calcineurin inhibitor, tacrolimus, on IL-6/sIL-6R-mediated RANKL expression through JAK2-STAT3-SOCS3 signaling pathway in fibroblast-like synoviocytes
Q89896777Rheumatoid arthritis: TAK-ing the road to suppress inflammation in synovial fibroblasts
Q91782570S1P-S1PR1 Signaling: the "Sphinx" in Osteoimmunology
Q42578542Safety and efficacy of tocilizumab for the treatment of rheumatoid arthritis
Q37315782Sarilumab plus methotrexate suppresses circulating biomarkers of bone resorption and synovial damage in patients with rheumatoid arthritis and inadequate response to methotrexate: a biomarker study of MOBILITY
Q38755912Selected cytokine pathways in rheumatoid arthritis
Q88592126Soluble Tumor Necrosis Factor Alpha Receptor 1, Bone Resorption, and Bone Mineral Density in the Year Following Hip Fractures: The Baltimore Hip Studies
Q28076558Spotlight on sirukumab for the treatment of rheumatoid arthritis: the evidence to date
Q38411334Subcutaneous formulation of tocilizumab for treatment of rheumatoid arthritis
Q39415136T-helper 17 cells mediate the osteo/odontoclastogenesis induced by excessive orthodontic forces
Q30396344TLR4 drives the pathogenesis of acquired cholesteatoma by promoting local inflammation and bone destruction
Q38625497TNF-α-induced miR-155 regulates IL-6 signaling in rheumatoid synovial fibroblasts
Q64118169Targeting Activated Synovial Fibroblasts in Rheumatoid Arthritis by Peficitinib
Q92712185The Autophagy in Osteoimmonology: Self-Eating, Maintenance, and Beyond
Q51720215The Pro-inflammatory Cytokine Interleukin-6 Regulates Nanoparticle Transport Across Model Follicle-Associated Epithelium Cells.
Q59793706The Two-Faced Cytokine IL-6 in Host Defense and Diseases
Q39311198The growth and osteoclastogenic effects of fibroblasts isolated from keratocystic odontogenic tumor
Q54379042The p38-mediated rapid down-regulation of cell surface gp130 expression impairs interleukin-6 signaling in the synovial fluid of juvenile idiopathic arthritis patients.
Q38685086The role and therapeutic targeting of IL-6 in rheumatoid arthritis.
Q39248512The role of stromal cells in inflammatory bone loss
Q35429154The roles of interleukin-6 in the pathogenesis of rheumatoid arthritis
Q39350335Therapeutic effects of a novel tylophorine analog, NK-007, on collagen-induced arthritis through suppressing tumor necrosis factor α production and Th17 cell differentiation
Q35724900Tocilizumab for the treatment of rheumatoid arthritis and other systemic autoimmune diseases: current perspectives and future directions
Q38044757Tocilizumab for the treatment of systemic juvenile idiopathic arthritis
Q60300744Tocilizumab in the treatment of rheumatoid arthritis: an evidence-based review and patient selection
Q38237564Tocilizumab, a humanized anti-IL-6R antibody, as an emerging therapeutic option for rheumatoid arthritis: molecular and cellular mechanistic insights
Q37358242Tocilizumab, a humanized anti-interleukin-6 receptor antibody, for treatment of rheumatoid arthritis
Q34974033Transglutaminase factor XIII promotes arthritis through mechanisms linked to inflammation and bone erosion
Q64102242Updates on Osteoimmunology: What's New on the Cross-Talk Between Bone and Immune System