The identification and characterisation of novel KIT transcripts in aggressive mast cell malignancies and normal CD34+ cells

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The identification and characterisation of novel KIT transcripts in aggressive mast cell malignancies and normal CD34+ cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1080/10428190802140865
P698PubMed publication ID18766971
P5875ResearchGate publication ID23233145

P50authorCem AkinQ42415677
James W VardimanQ107318760
P2093author name stringLucy A Godley
John Anastasi
Kelly R Ostler
Ozden Ozer
Yi D Zhao
P2860cites workActivating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosisQ22001442
One-step detection of c-kit point mutations using peptide nucleic acid-mediated polymerase chain reaction clamping and hybridization probesQ24685763
Crystal structure of human stem cell factor: implication for stem cell factor receptor dimerization and activationQ27625275
Prognostic impact of c-KIT mutations in core binding factor leukemias: an Italian retrospective studyQ27824856
Gain-of-function mutations of c-kit in human gastrointestinal stromal tumorsQ28118852
Oncogenic kinase signallingQ28189493
The complexity of KIT gene mutations and chromosome rearrangements and their clinical correlation in gastrointestinal stromal (pacemaker cell) tumorsQ28344793
pEF-BOS, a powerful mammalian expression vectorQ29547606
AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec.Q33762738
Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorderQ33784323
Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptorQ34567286
Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): a Cancer and Leukemia Group B StudyQ34570206
Kit and c-kit mutations in mastocytosis: a short overview with special reference to novel molecular and diagnostic concepts.Q34580164
Recent advances in the understanding of mastocytosis: the role of KIT mutations.Q34635424
Mastocytosis: state of the art.Q34641105
W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activityQ34719633
KIT mutations are common in testicular seminomasQ35083255
Systemic mastocytosis with associated clonal haematological non-mast cell lineage diseases: a histopathological challengeQ35587647
Immunophenotyping of acute leukemias and myelodysplastic syndromesQ35679885
Juxtamembrane autoinhibition in receptor tyrosine kinases.Q35790329
Exon skipping by mutation of an authentic splice site of c-kit gene in W/W mouseQ35918061
Clonality and molecular pathogenesis of mastocytosis.Q36182758
Genetics of myeloid malignancies: pathogenetic and clinical implicationsQ36254578
Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit productQ38315689
Multiple novel alterations in Kit tyrosine kinase in patients with gastrointestinally pronounced systemic mast cell activation disorderQ40091176
Newly identified c-KIT receptor tyrosine kinase ITD in childhood AML induces ligand-independent growth and is responsive to a synergistic effect of imatinib and rapamycinQ40255904
KIT-D816 mutations in AML1-ETO-positive AML are associated with impaired event-free and overall survivalQ40357255
Regulation of development, survival and neoplastic growth of mast cells through the c-kit receptorQ40402590
Identification of activating c-kit mutations in adult-, but not in childhood-onset indolent mastocytosis: a possible explanation for divergent clinical behaviorQ40987642
Establishment of an immature mast cell line from a patient with mast cell leukemiaQ41296878
Inhibition of spontaneous receptor phosphorylation by residues in a putative alpha-helix in the KIT intracellular juxtamembrane region.Q42471466
Apparent KIT Ser(715) deletion in GIST mRNA is not detectable in genomic DNA and represents a previously known splice variant of KIT transcriptQ42855828
Systemic mastocytosis with associated clonal hematological non‐mast‐cell lineage disease: Analysis of clinicopathologic features and activating c‐kit mutationsQ43493292
Activating mutations of RTK/ras signal transduction pathway in pediatric acute myeloid leukemiaQ44408358
A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinibQ44534510
Effects of tyrosine kinase inhibitor STI571 on human mast cells bearing wild-type or mutated c-kitQ44539087
Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinaseQ44881257
Mutations in the receptor tyrosine kinase pathway are associated with clinical outcome in patients with acute myeloblastic leukemia harboring t(8;21)(q22;q22).Q46497558
KIT mutations, and not FLT3 internal tandem duplication, are strongly associated with a poor prognosis in pediatric acute myeloid leukemia with t(8;21): a study of the Japanese Childhood AML Cooperative Study GroupQ46807536
Cooperating mutations of receptor tyrosine kinases and Ras genes in childhood core-binding factor acute myeloid leukemia and a comparative analysis on paired diagnosis and relapse samplesQ46932369
Mutational analysis of the KIT gene in myelodysplastic syndrome (MDS) and MDS-derived leukemiaQ46988174
Clinicopathologic, phenotypic, and genotypic characteristics of gastrointestinal mesenchymal tumorsQ47271715
Neoplastic mast cells in systemic mastocytosis associated with t(8;21) acute myeloid leukemia are derived from the leukemic cloneQ47592508
Incidence and prognostic impact of c-Kit, FLT3, and Ras gene mutations in core binding factor acute myeloid leukemia (CBF-AML).Q52569827
P433issue8
P921main subjectmast cellQ191989
P304page(s)1567-1577
P577publication date2008-08-01
P1433published inLeukemia & LymphomaQ6534493
P1476titleThe identification and characterisation of novel KIT transcripts in aggressive mast cell malignancies and normal CD34+ cells
P478volume49

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cites work (P2860)
Q42908309Comparative analysis of mutation of tyrosine kinase kit in mast cells from patients with systemic mast cell activation syndrome and healthy subjects
Q38025156Diagnosis, progression patterns and prognostication in mastocytosis
Q37276382KIT GNNK splice variants: expression in systemic mastocytosis and influence on the activating potential of the D816V mutation in mast cells

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