The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species

scientific article published in March 2017

The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.DEVCEL.2017.02.020
P932PMC publication ID5398851
P698PubMed publication ID28350990

P50authorVeronika ÁdámQ1469292
Nolan W KennedyQ89632608
P2093author name stringAhmed Khalil
Hiromi Sesaki
Nagendra Yadava
R Blake Hill
László Tretter
Brian A Roelofs
Mariusz Karbowski
Kie Itoh
Edward Cherok
Brian M Polster
Alexandrea M Miller
Andrew J Saladino
Evan A Bordt
Lora K Picton
Pascaline Clerc
Shealinna X Ge
Sruti Uppuluri
T Chase Francis
Tanya Kumar
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Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in miceQ29617092
Vectors for the inducible overexpression of glutathione S-transferase fusion proteins in yeastQ29618547
Dynasore, a cell-permeable inhibitor of dynaminQ29619881
Mechanism of toxicity in rotenone models of Parkinson's diseaseQ33974271
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Mitochondrial DNA variant associated with Leber hereditary optic neuropathy and high-altitude Tibetans.Q34269615
Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neuronsQ34383447
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.Q34447034
Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivoQ34470315
Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.Q34506457
Direct binding of the dynamin-like GTPase, Dnm1, to mitochondrial dynamics protein Fis1 is negatively regulated by the Fis1 N-terminal armQ34613362
Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brainQ34806899
Inhibition of the mitochondrial fission protein dynamin-related protein 1 improves survival in a murine cardiac arrest model.Q35125282
Mitochondrial respiratory complex I dysfunction promotes tumorigenesis through ROS alteration and AKT activationQ35532937
Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's DiseaseQ35733751
Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart FailureQ35775155
Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damageQ35962319
Mitochondrial metabolism of reactive oxygen species.Q36088215
Molecular remedy of complex I defects: rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria restores the NADH oxidase activity of complex I-deficient mammalian cellsQ36252857
Mitochondrial E3 ubiquitin ligase MARCH5 controls mitochondrial fission and cell sensitivity to stress-induced apoptosis through regulation of MiD49 proteinQ36463355
Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilizationQ36496658
Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal LifespanQ36809576
Bcl-x L increases mitochondrial fission, fusion, and biomass in neuronsQ37202353
The dynamin-related GTPase Drp1 is required for embryonic and brain development in miceQ37365414
Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria.Q37417088
Drp1 is dispensable for apoptotic cytochrome c release in primed MCF10A and fibroblast cells but affects Bcl-2 antagonist-induced respiratory changesQ37686266
Metformin, besides exhibiting strong in vivo anti-inflammatory properties, increases mptp-induced damage to the nigrostriatal dopaminergic systemQ38786792
Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells.Q38847446
Inhibition of Drp1 provides neuroprotection in vitro and in vivo.Q39386090
Histologic fixatives suitable for diagnostic light and electron microscopyQ39393868
Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injuryQ39710554
Mitochondrial division inhibitor 1 (Mdivi-1) offers neuroprotection through diminishing cell death and improving functional outcome in a mouse model of traumatic brain injuryQ40286462
A Targeted Mutation Identified through pKa Measurements Indicates a Postrecruitment Role for Fis1 in Yeast Mitochondrial Fission.Q41161606
Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington's diseaseQ41998875
A continuous, regenerative coupled GTPase assay for dynamin-related proteinsQ42168338
Suppressors of Superoxide-H2O2 Production at Site IQ of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion InjuryQ42383841
Spare respiratory capacity rather than oxidative stress regulates glutamate excitotoxicity after partial respiratory inhibition of mitochondrial complex I with rotenone.Q42515219
DeltaPsi(m)-Dependent and -independent production of reactive oxygen species by rat brain mitochondriaQ43777368
Rapid isolation of metabolically active mitochondria from rat brain and subregions using Percoll density gradient centrifugationQ43950113
Regulation of brain mitochondrial H2O2 production by membrane potential and NAD(P)H redox state.Q44545123
A fluorescence-based technique for screening compounds that protect against damage to brain mitochondriaQ45008767
Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeothermsQ46426971
The mitochondrial division inhibitor mdivi-1 attenuates spinal cord ischemia-reperfusion injury both in vitro and in vivo: Involvement of BK channelsQ48258236
The effect of bovine serum albumin on the membrane potential and reactive oxygen species generation in succinate-supported isolated brain mitochondriaQ48423686
Moderate dependence of ROS formation on DeltaPsim in isolated brain mitochondria supported by NADH-linked substratesQ48437193
Differential expression of apoptotic protease-activating factor-1 and caspase-3 genes and susceptibility to apoptosis during brain development and after traumatic brain injury.Q48785790
The ROS production induced by a reverse-electron flux at respiratory-chain complex 1 is hampered by metformin.Q52668520
Pathways of electron flow established by tetramethyl-phenylenediamine in mitochondria and ascites tumor cellsQ54418026
P4510describes a project that usesImageJQ1659584
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectreactive oxygen speciesQ424361
P304page(s)583-594.e6
P577publication date2017-03-01
P1433published inDevelopmental CellQ1524277
P1476titleThe Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species
P478volume40

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