Calcium oxalate crystals induces tight junction disruption in distal renal tubular epithelial cells by activating ROS/Akt/p38 MAPK signaling pathway

scientific article published in November 2017

Calcium oxalate crystals induces tight junction disruption in distal renal tubular epithelial cells by activating ROS/Akt/p38 MAPK signaling pathway is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1080/0886022X.2017.1305968
P8608Fatcat IDrelease_m2wvsbigpzg6dozkiw7i3erksy
P932PMC publication ID6014313
P698PubMed publication ID28335665

P2093author name stringLei Yu
Ruihua An
Xukun Liu
Xiuguo Gan
P2860cites workMadin-Darby canine kidney cells are injured by exposure to oxalate and to calcium oxalate crystals.Q50776917
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Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1Q24290731
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathwaysQ24309037
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Switching Akt: from survival signaling to deadly responseQ24632379
From receptors to stress-activated MAP kinasesQ28137773
Oxalate upregulates expression of IL-2Rβ and activates IL-2R signaling in HK-2 cells, a line of human renal epithelial cellsQ28538519
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Increased calcium oxalate monohydrate crystal binding to injured renal tubular epithelial cells in culture.Q32061961
Survival signaling by C-RAF: mitochondrial reactive oxygen species and Ca2+ are critical targetsQ33315751
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Signalling to and from tight junctionsQ34180670
Changes in mitochondrial proteome of renal tubular cells induced by calcium oxalate monohydrate crystal adhesion and internalization are related to mitochondrial dysfunctionQ34237316
ROS, mitochondria and the regulation of autophagyQ34679713
Functional analysis of tight junctionsQ35150365
Apoptotic events induced by high glucose in human hepatoma HepG2 cells involve endoplasmic reticulum stress and MAPK's activationQ35313600
Clinical practice. Calcium kidney stonesQ35335724
Podophyllotoxin acetate enhances γ-ionizing radiation-induced apoptotic cell death by stimulating the ROS/p38/caspase pathwayQ35578808
Crystal-induced inflammation of the kidneys: results from human studies, animal models, and tissue-culture studiesQ35827381
Insights on the pathology of kidney stone formationQ36217570
p38 MAPK mediates calcium oxalate crystal-induced tight junction disruption in distal renal tubular epithelial cellsQ36518967
Oxidative stress mediates the disruption of airway epithelial tight junctions through a TRPM2-PLCγ1-PKCα signaling pathway.Q36913604
Apoptosis signal-regulating kinase 1 in stress and immune responseQ36947070
Gallotannin suppresses calcium oxalate crystal binding and oxalate-induced oxidative stress in renal epithelial cellsQ37542689
Reactive oxygen species as the molecular modulators of calcium oxalate kidney stone formation: evidence from clinical and experimental investigationsQ38047594
MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivoQ38431323
ROS-activated p38 MAPK/ERK-Akt cascade plays a central role in palmitic acid-stimulated hepatocyte proliferationQ39534614
TNFalpha-induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase, Akt and NFkappaB signalingQ39634008
Effects of calcium oxalate monohydrate crystals on expression and function of tight junction of renal tubular epithelial cellsQ39653496
Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signalingQ40116310
Reactive oxygen species mediated calcium oxalate crystal-induced expression of MCP-1 in HK-2 cellsQ40332945
ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity.Q40428511
Oxidative stress affects the junctional integrity of retinal pigment epithelial cells.Q40595305
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Oxidant-induced disruption of intestinal epithelial barrier function: role of protein tyrosine phosphorylationQ41081191
MAPK interacts with occludin and mediates EGF-induced prevention of tight junction disruption by hydrogen peroxideQ41964987
Cooperation between snail and LEF-1 transcription factors is essential for TGF-beta1-induced epithelial-mesenchymal transitionQ42126608
Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration.Q42492769
Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosisQ42601114
Oxidative renal cell injury induced by calcium oxalate crystal and renoprotection with antioxidants: a possible role of oxidative stress in nephrolithiasisQ43139185
Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cellsQ43883726
Expression of kinase-inactive c-Src delays oxidative stress-induced disassembly and accelerates calcium-mediated reassembly of tight junctions in the Caco-2 cell monolayerQ44291107
Oxalate and calcium oxalate mediated free radical toxicity in renal epithelial cells: effect of antioxidantsQ44354199
Oxidative stress-induced disruption of epithelial and endothelial tight junctions.Q46570774
Factors determining types and morphologies of calcium oxalate crystals: molar concentrations, buffering, pH, stirring and temperatureQ46928345
Signaling mechanisms of HIV-1 Tat-induced alterations of claudin-5 expression in brain endothelial cellsQ48939388
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P921main subjectcalcium oxalateQ412399
P304page(s)440-451
P577publication date2017-11-01
P1433published inRenal FailureQ15762963
P1476titleCalcium oxalate crystals induces tight junction disruption in distal renal tubular epithelial cells by activating ROS/Akt/p38 MAPK signaling pathway
P478volume39

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cites work (P2860)
Q92341731Diabetes inhibits corneal epithelial cell migration and tight junction formation in mice and human via increasing ROS and impairing Akt signaling
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