Fatty acids liberated from low-density lipoprotein trigger endothelial apoptosis via mitogen-activated protein kinases

scientific article published in August 2005

Fatty acids liberated from low-density lipoprotein trigger endothelial apoptosis via mitogen-activated protein kinases is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/SJ.CDD.4401633
P698PubMed publication ID15846374
P5875ResearchGate publication ID7891956

P50authorHidenori IchijōQ37376351
P2093author name stringBhakdi S
Husmann M
Dersch K
P2860cites workActivation of apoptosis signal-regulating kinase 1 by the stress-induced activating phosphorylation of pre-formed oligomerQ24292799
A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3Q24320233
Enzymatically modified LDL induces cathepsin H in human monocytes: potential relevance in early atherogenesisQ28180222
Lysosomal Enzymes Are Released From Cultured Human Macrophages, Hydrolyze LDL In Vitro, and Are Present Extracellularly in Human Atherosclerotic LesionsQ28204360
New phospholipase A2 isozymes with a potential role in atherosclerosisQ34264067
Regulation of endothelial cell apoptosis in atherothrombosisQ34916121
Roles of MAPKKK ASK1 in stress-induced cell death.Q35091348
Role of apoptosis in atherosclerosis and its therapeutic implicationsQ35824718
On the pathogenesis of atherosclerosis: enzymatic transformation of human low density lipoprotein to an atherogenic moietyQ36365606
In vivo action of 15-lipoxygenase in early stages of human atherogenesisQ37364268
Foam cells and atherogenesisQ39836558
p38 MAPK mediates TNF-induced apoptosis in endothelial cells via phosphorylation and downregulation of Bcl-x(L).Q40533259
Isolation and characterization of a complement-activating lipid extracted from human atherosclerotic lesionsQ41954726
Enzymatically modified nonoxidized low-density lipoprotein induces interleukin-8 in human endothelial cells: role of free fatty acidsQ44213383
Free fatty acids trigger apoptosis and inhibit cell cycle progression in human vascular endothelial cellsQ44641981
Possible protective role for C-reactive protein in atherogenesis: complement activation by modified lipoproteins halts before detrimental terminal sequenceQ44810016
Enzymatic modification of low-density lipoprotein in the arterial wall: a new role for plasmin and matrix metalloproteinases in atherogenesisQ45042444
LDL-activated p38 in endothelial cells is mediated by Ras.Q46062570
Beyond cholesterol: the enigma of atherosclerosis revisitedQ50955462
ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosisQ57267073
Scavenger receptor-independent stimulation of cholesterol esterification in macrophages by low density lipoprotein extracted from human aortic intimaQ68110135
Complement and atherogenesis: binding of CRP to degraded, nonoxidized LDL enhances complement activationQ73083027
Immunohistochemical demonstration of enzymatically modified human LDL and its colocalization with the terminal complement complex in the early atherosclerotic lesionQ74351422
Activation of the p38 MAP kinase pathway is required for foam cell formation from macrophages exposed to oxidized LDLQ74648768
Atherogenic properties of enzymatically degraded LDL: selective induction of MCP-1 and cytotoxic effects on human macrophagesQ77318962
P433issue8
P921main subjectlipoproteinQ28350
P304page(s)1107-1114
P577publication date2005-08-01
P1433published inCell Death & DifferentiationQ2943974
P1476titleFatty acids liberated from low-density lipoprotein trigger endothelial apoptosis via mitogen-activated protein kinases
P478volume12

Reverse relations

cites work (P2860)
Q33727103Activation of the AMP-activated protein kinase-p38 MAP kinase pathway mediates apoptosis induced by conjugated linoleic acid in p53-mutant mouse mammary tumor cells
Q51447981Association of liver disease with postprandial large intestinal triglyceride-rich lipoprotein accumulation and pro/antioxidant imbalance in normolipidemic non-alcoholic steatohepatitis.
Q40309156Critical role of ASK1 in the 6-hydroxydopamine-induced apoptosis in human neuroblastoma SH-SY5Y cells.
Q46444254Different mechanisms of saturated versus polyunsaturated FFA-induced apoptosis in human endothelial cells
Q37215455Effects of insulin and free fatty acids on matrix metalloproteinases
Q36681348Initiation and progression of atherosclerosis--enzymatic or oxidative modification of low-density lipoprotein?
Q81802750LDL protein nitration: implication for LDL protein unfolding
Q39705919Pro-autophagic signal induction by bacterial pore-forming toxins
Q24310371Protein kinase C iota mediates lipid-induced apoptosis of human coronary artery endothelial cells
Q42921952The Autodigestion Hypothesis in Shock and Multi-Organ Failure: Degrading Protease Activity.
Q92178803The Role of Distinctive Sphingolipids in the Inflammatory and Apoptotic Effects of Electronegative LDL on Monocytes
Q46695841The intestine as source of cytotoxic mediators in shock: free fatty acids and degradation of lipid-binding proteins
Q53594219p38 Mitogen-activated protein kinase mediates free fatty acid-induced gluconeogenesis in hepatocytes.

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