Suitable Concentrations of Uric Acid Can Reduce Cell Death in Models of OGD and Cerebral Ischemia-Reperfusion Injury

scientific article published on 5 October 2016

Suitable Concentrations of Uric Acid Can Reduce Cell Death in Models of OGD and Cerebral Ischemia-Reperfusion Injury is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S10571-016-0430-8
P698PubMed publication ID27709309

P2093author name stringFeng Zhang
Bin Zhang
Ning Yang
Shao-Peng Lin
P2860cites workPrognostic significance of uric acid serum concentration in patients with acute ischemic strokeQ28192706
Uric acid protects neurons against excitotoxic and metabolic insults in cell culture, and against focal ischemic brain injury in vivoQ32027902
Is elevated SUA associated with a worse outcome in young Chinese patients with acute cerebral ischemic stroke?Q33694991
Uric acid administration in patients with acute stroke: a novel approach to neuroprotectionQ37083643
Injury and repair mechanisms in ischemic stroke: considerations for the development of novel neurotherapeutics.Q37541913
NADPH oxidases as therapeutic targets in ischemic stroke.Q38012354
Serum Uric Acid Levels and Outcomes After Acute Ischemic StrokeQ38368304
The role of uric acid as a potential neuroprotectant in acute ischemic stroke: a review of literatureQ38378478
Uric Acid Therapy Improves Clinical Outcome in Women With Acute Ischemic Stroke.Q38408321
National stroke registries for monitoring and improving the quality of hospital care: A systematic reviewQ38695414
High levels of serum uric acid are associated with silent brain infarctionQ39851651
Serum urate as an independent predictor of poor outcome and future vascular events after acute stroke.Q40576886
Serum uric acid is neuroprotective in Chinese patients with acute ischemic stroke treated with intravenous recombinant tissue plasminogen activatorQ41147676
The URICO-ICTUS study, a phase 3 study of combined treatment with uric acid and rtPA administered intravenously in acute ischaemic stroke patients within the first 4.5 h of onset of symptoms.Q42968240
Is uric acid protective or deleterious in acute ischemic stroke? A prospective cohort studyQ43275781
Decreased uric acid levels correlate with poor outcomes in acute ischemic stroke patients, but not in cerebral hemorrhage patientsQ43917486
Dose-response relationship of serum uric acid levels with risk of stroke mortalityQ44846535
Uric acid-driven Th17 differentiation requires inflammasome-derived IL-1 and IL-18.Q46158395
Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin-angiotensin systemQ46809905
Course of matrix metalloproteinase-9 isoforms after the administration of uric acid in patients with acute stroke: a proof-of-concept studyQ47794204
A pilot study of dual treatment with recombinant tissue plasminogen activator and uric acid in acute ischemic strokeQ48156395
Uric acid improves glucose-driven oxidative stress in human ischemic strokeQ48357007
Decrease in uric acid in acute ischemic stroke correlates with stroke severity, evolution and outcomeQ48374884
Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic strokeQ48593375
Serum uric acid and risk of ischemic stroke: the ARIC StudyQ48722176
Safety and efficacy of uric acid in patients with acute stroke (URICO-ICTUS): a randomised, double-blind phase 2b/3 trial.Q50702011
Uric Acid Levels Are Relevant in Patients With Stroke Treated With ThrombolysisQ63385154
Soluble uric acid primes TLR-induced proinflammatory cytokine production by human primary cells via inhibition of IL-1RaQ86653435
P433issue5
P921main subjectcerebral infarctionQ1209150
reperfusion injuryQ1413991
P304page(s)931-939
P577publication date2016-10-05
P1433published inCellular and Molecular NeurobiologyQ2333197
P1476titleSuitable Concentrations of Uric Acid Can Reduce Cell Death in Models of OGD and Cerebral Ischemia-Reperfusion Injury
P478volume37

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cites work (P2860)
Q57159631A new era for stroke therapy: Integrating neurovascular protection with optimal reperfusion
Q47188375Evaluation of efficacy and safety of Reteplase and Alteplase in the treatment of hyper-acute cerebral infarction
Q92243841Serum Uric Acid and Triglycerides in Chinese Patients with Newly Diagnosed Moyamoya Disease: A Cross-Sectional Study
Q89871246The protective effect of uric acid in reducing TLR4/NF-κB activation through the inhibition of HMGB1 acetylation in a model of ischemia-reperfusion injury in vitro
Q52746389Uric acid promotes oxidative stress and enhances vascular endothelial cell apoptosis in rats with middle cerebral artery occlusion.

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