Stereoselective total synthesis of epothilones by the metathesis approach involving C9-C10 bond formation

scientific article published in April 2002

Stereoselective total synthesis of epothilones by the metathesis approach involving C9-C10 bond formation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/1521-3773(20020415)41:8<1381::AID-ANIE1381>3.0.CO;2-O
P698PubMed publication ID19750771

P2093author name stringJian Sun
Subhash C Sinha
P2860cites workConcise total syntheses of epothilone A and C based on alkyne metathesisQ57945480
Epothilone A and B—Novel 16-Membered Macrolides with Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in SolutionQ60357921
Total Synthesis of Epothilone A: The Olefin Metathesis ApproachQ60357925
Total Synthesis of(−)-Epothilone AQ60357927
Total synthesis of epothilones B and DQ74146417
Synthesis and biological activity of novel epothilone aziridinesQ74378229
Studies toward a Synthesis of Epothilone A: Stereocontrolled Assembly of the Acyl Region and Models for MacrocyclizationQ74824762
Total synthesis of epothilone BQ77143289
Chemical Biology of EpothilonesQ88519454
Stereoselective syntheses of epothilones A and B via directed nitrile oxide cycloadditionQ28208674
Synthesis and Applications of RuCl2(CHR‘)(PR3)2:  The Influence of the Alkylidene Moiety on Metathesis ActivityQ30040302
Synthesis and activity of a new generation of ruthenium-based olefin metathesis catalysts coordinated with 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene ligandsQ30596579
Synthesis of natural-product-based compound librariesQ30873370
Microtubule-stabilizing agents: a growing class of important anticancer drugsQ34318072
Recent developments in the chemistry, biology and medicine of the epothilonesQ34870258
The synthesis, discovery, and development of a highly promising class of microtubule stabilization agents: curative effects of desoxyepothilones B and F against human tumor xenografts in nude miceQ36541279
The antibody catalysis route to the total synthesis of epothilonesQ36752669
Antitumor efficacy of 26-fluoroepothilone B against human prostate cancer xenograftsQ40768370
Chemical synthesis and biological evaluation of cis- and trans-12,13-cyclopropyl and 12,13-cyclobutyl epothilones and related pyridine side chain analogues.Q40779922
Total synthesis of epothilone B, epothilone D, and cis- and trans-9,10-dehydroepothilone D.Q40801585
Synthesis of trisubstituted alkenes via olefin cross-metathesisQ41738988
Catalytic antibody route to the naturally occurring epothilones: total synthesis of epothilones A-F.Q43605353
The 12,13-diol cyclization approach for a truly stereocontrolled total synthesis of epothilone B and the synthesis of a conformationally restrained analogueQ43644646
Synthesis of epothilone analogues by antibody-catalyzed resolution of thiazole aldol synthons on a multigram scale. Biological consequences of C-13 alkylation of epothilonesQ43877268
New insights into the mechanism of ruthenium-catalyzed olefin metathesis reactionsQ46092178
Mechanism and activity of ruthenium olefin metathesis catalystsQ46357398
Total synthesis of 16-desmethylepothilone B, epothilone B10, epothilone F, and related side chain modified epothilone B analoguesQ46483091
Insights into long-range structural effects on the stereochemistry of aldol condensations: a practical total synthesis of desoxyepothilone F.Q49328538
Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)).Q52196656
Epothilon A und B – neuartige, 16gliedrige Makrolide mit cytotoxischer Wirkung: Isolierung, Struktur im Kristall und Konformation in LösungQ56681180
P433issue8
P921main subjectstereoselectivityQ903429
P304page(s)1381-1383
P577publication date2002-04-01
P1433published inAngewandte ChemieQ538683
P1476titleStereoselective total synthesis of epothilones by the metathesis approach involving C9-C10 bond formation
P478volume41

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cites work (P2860)
Q356835774. The natural products epothilones A and B as lead structures for anticancer drug discovery: chemistry, biology, and SAR studies
Q36752835The chemistry and biology of epothilones--the wheel keeps turning.
Q83329353Total synthesis of epothilones A-F
Q37329400Total synthesis of epothilones B and D: stannane equivalents for beta-keto ester dianions

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