BRAF V600E-specific immunohistochemistry reveals low mutation rates in biliary tract cancer and restriction to intrahepatic cholangiocarcinoma

scientific article published on 6 December 2013

BRAF V600E-specific immunohistochemistry reveals low mutation rates in biliary tract cancer and restriction to intrahepatic cholangiocarcinoma is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/MODPATHOL.2013.206
P698PubMed publication ID24309328
P5875ResearchGate publication ID259205147

P50authorDavid CapperQ63366395
Arianeb MehrabiQ67168816
Andreas von DeimlingQ40381084
Wilko WeichertQ40935156
P2093author name stringAlbrecht Stenzinger
Frederick Klauschen
Arne Warth
Peter Schirmacher
Marcus Renner
Benjamin Goeppert
Monika Nadja Vogel
Stephanie Roessler
Mohammadreza Hafezi
Lena Frauenschuh
Katja Boehmer
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Improved survival with vemurafenib in melanoma with BRAF V600E mutationQ24631953
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Targeting the BRAF V600E mutation in multiple myelomaQ27852220
Inhibition of Mutated, Activated BRAF in Metastatic MelanomaQ27860458
Mutations of the BRAF gene in human cancerQ27860760
Immunohistochemical testing of BRAF V600E status in 1,120 tumor tissue samples of patients with brain metastasesQ28250795
Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trialQ29614756
Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitorsQ34104493
Immunohistochemical analysis of BRAF(V600E) expression of primary and metastatic melanoma and comparison with mutation status and melanocyte differentiation antigens of metastatic lesionsQ34501265
Effect of dabrafenib on melanoma cell lines harbouring the BRAF(V600D/R) mutationsQ34547540
Molecular profiling of cholangiocarcinoma shows potential for targeted therapy treatment decisionsQ34580542
Clinical diagnosis and staging of cholangiocarcinomaQ34631337
BRAFV600E immunohistochemistry facilitates universal screening of colorectal cancers for Lynch syndromeQ34782265
Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotypingQ35705307
Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomesQ36759538
BRAF(E600) in benign and malignant human tumoursQ36921234
Association between BRAF V600E mutation and mortality in patients with papillary thyroid cancerQ37216703
Clinical responses to vemurafenib in patients with metastatic papillary thyroid cancer harboring BRAF(V600E) mutationQ37667684
Genetics of biliary tract cancers and emerging targeted therapiesQ37765099
Targeting BRAF for patients with melanoma.Q37817713
The V599E BRAF mutation is uncommon in biliary tract cancersQ38447459
Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytomaQ39788891
Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinomaQ43005729
Detection of BRAF p.V600E mutations in melanomas: comparison of four methods argues for sequential use of immunohistochemistry and pyrosequencing.Q43815115
Diagnostic value of immunohistochemistry for the detection of the BRAFV600E mutation in primary lung adenocarcinoma Caucasian patients.Q43853831
Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, phase 2 trialQ44442912
Mutant BRAF V600E protein in ganglioglioma is predominantly expressed by neuronal tumor cellsQ45392719
Immunohistochemical detection of the BRAF V600E-mutated protein in papillary thyroid carcinoma.Q46002239
Mutational analysis of BRAF in gallbladder carcinomas in association with K-ras and p53 mutations and microsatellite instability.Q47280618
Brainstem ganglioglioma successfully treated with vemurafenibQ48189758
Utilization of a MAB for BRAF(V600E) detection in papillary thyroid carcinoma.Q54291167
A role for immunohistochemical detection of BRAF V600E prior to BRAF-inhibitor treatment of malignant melanoma?Q54441873
Immunohistochemistry is highly sensitive and specific for the detection of V600E BRAF mutation in melanoma.Q54480523
BRAF inhibition in refractory hairy-cell leukemia.Q54509211
Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma.Q54610975
P433issue7
P921main subjectcholangiocarcinomaQ124292
immunohistochemistryQ899285
???Q18556397
P304page(s)1028-1034
P577publication date2013-12-06
P1433published inModern PathologyQ15724578
P1476titleBRAF V600E-specific immunohistochemistry reveals low mutation rates in biliary tract cancer and restriction to intrahepatic cholangiocarcinoma
P478volume27

Reverse relations

cites work (P2860)
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Q101353785Dabrafenib plus trametinib in patients with BRAFV600E-mutated biliary tract cancer - Authors' reply
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