Methionine sulfoxide and proteolytic cleavage contribute to the inactivation of cathepsin G by hypochlorous acid: an oxidative mechanism for regulation of serine proteinases by myeloperoxidase

scientific article published on 20 June 2005

Methionine sulfoxide and proteolytic cleavage contribute to the inactivation of cathepsin G by hypochlorous acid: an oxidative mechanism for regulation of serine proteinases by myeloperoxidase is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M504040200
P698PubMed publication ID15967795

P50authorBaohai ShaoQ37370740
P2093author name stringChristophe L M J Verlinde
Jay W Heinecke
Xiaoyun Fu
Abderrazzaq Belaaouaj
P2860cites workKilling activity of neutrophils is mediated through activation of proteases by K+ fluxQ24292504
Oxidation of low-density lipoprotein by hypochlorite causes aggregation that is mediated by modification of lysine residues rather than lipid oxidationQ24528264
Tyrosyl radical generated by myeloperoxidase catalyzes the oxidative cross-linking of proteinsQ24564612
Cell surface-bound elastase and cathepsin G on human neutrophils: a novel, non-oxidative mechanism by which neutrophils focus and preserve catalytic activity of serine proteinasesQ24672373
Increased atherosclerosis in myeloperoxidase-deficient miceQ28350068
Oxidative cross-linking of tryptophan to glycine restrains matrix metalloproteinase activity: specific structural motifs control protein oxidationQ33195893
Structural and energetic determinants of the S1-site specificity in serine proteasesQ33548213
Mechanisms of oxidative damage by myeloperoxidase in atherosclerosis and other inflammatory disordersQ33603019
Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsisQ33947266
Comparative reactivities of various biological compounds with myeloperoxidase-hydrogen peroxide-chloride, and similarity of the oxidant to hypochloriteQ34048534
Phagocytes produce 5-chlorouracil and 5-bromouracil, two mutagenic products of myeloperoxidase, in human inflammatory tissueQ34191993
Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trialsQ34206974
Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agentQ34501431
Superoxide-mediated modification of low density lipoprotein by arterial smooth muscle cellsQ34526444
Human neutrophils employ chlorine gas as an oxidant during phagocytosisQ37359571
3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intimaQ37366288
Tissue destruction by neutrophilsQ38264463
Proteolysis of the human platelet and endothelial cell thrombin receptor by neutrophil-derived cathepsin G.Q38295412
Human plasma proteinase inhibitorsQ40107740
Oxygen Metabolism and the Toxic Properties of PhagocytesQ40122453
Absolute rate constants for the reaction of hypochlorous acid with protein side chains and peptide bondsQ40681776
Phagocytosing human neutrophils inactivate their own granular enzymesQ40683509
Quantum proteolysis by neutrophils: implications for pulmonary emphysema in alpha 1-antitrypsin deficiencyQ40851166
Hypochlorite-induced damage to proteins: formation of nitrogen-centred radicals from lysine residues and their role in protein fragmentationQ41952132
Hypochlorous acid oxygenates the cysteine switch domain of pro-matrilysin (MMP-7). A mechanism for matrix metalloproteinase activation and atherosclerotic plaque rupture by myeloperoxidaseQ43726485
A sensitive new substrate for chymotrypsinQ44163410
Hypochlorous acid generated by myeloperoxidase modifies adjacent tryptophan and glycine residues in the catalytic domain of matrix metalloproteinase-7 (matrilysin): an oxidative mechanism for restraining proteolytic activity during inflammationQ44448828
Human leukocyte cathepsin G. Subsite mapping with 4-nitroanilides, chemical modification, and effect of possible cofactors.Q53735188
The Acid Ionization Constant of HOCl from 5 to 35°Q56340568
P433issue32
P407language of work or nameEnglishQ1860
P921main subjectproteolysisQ33123
P304page(s)29311-29321
P577publication date2005-06-20
P1433published inJournal of Biological ChemistryQ867727
P1476titleMethionine sulfoxide and proteolytic cleavage contribute to the inactivation of cathepsin G by hypochlorous acid: an oxidative mechanism for regulation of serine proteinases by myeloperoxidase
P478volume280

Reverse relations

cites work (P2860)
Q36139094Complementary LC-MS/MS-Based N-Glycan, N-Glycopeptide, and Intact N-Glycoprotein Profiling Reveals Unconventional Asn71-Glycosylation of Human Neutrophil Cathepsin G.
Q42118402Development of an SPR imaging biosensor for determination of cathepsin G in saliva and white blood cells.
Q42037362Effects of biological oxidants on the catalytic activity and structure of group VIA phospholipase A2
Q36445672Fibrin clot structure and mechanics associated with specific oxidation of methionine residues in fibrinogen.
Q48440996Hypochlorous acid induces apoptosis of cultured cortical neurons through activation of calpains and rupture of lysosomes
Q37485508Hypochlorous acid reacts with the N-terminal methionines of proteins to give dehydromethionine, a potential biomarker for neutrophil-induced oxidative stress
Q28504837Immunolocalization of hypochlorite-induced, catalase-bound free radical formation in mouse hepatocytes
Q42615245Lipid oxidation by hypochlorous acid: chlorinated lipids in atherosclerosis and myocardial ischemia
Q37440915Methionine sulfoxide reductase A (MsrA) restores alpha-crystallin chaperone activity lost upon methionine oxidation
Q34994685Myeloperoxidase in human neutrophil host defence
Q26767149Neutrophil-Mediated Regulation of Innate and Adaptive Immunity: The Role of Myeloperoxidase
Q38500988Quantification of biopharmaceuticals and biomarkers in complex biological matrices: a comparison of liquid chromatography coupled to tandem mass spectrometry and ligand binding assays
Q89881813Site-specific 5-hydroxy-tryptophan incorporation into apolipoprotein A-I impairs cholesterol efflux activity and high density lipoprotein biogenesis
Q37010298UVA causes dual inactivation of cathepsin B and L underlying lysosomal dysfunction in human dermal fibroblasts

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