Mechanisms of innate resistance to thymidylate synthase inhibition after 5-fluorouracil

scientific article published in October 1988

Mechanisms of innate resistance to thymidylate synthase inhibition after 5-fluorouracil is …
instance of (P31):
scholarly articleQ13442814

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P698PubMed publication ID3167844

P2093author name stringBernstein L
Frösing R
Hayes AA
Spears CP
Gustavsson BG
Berne M
P433issue20
P407language of work or nameEnglishQ1860
P304page(s)5894-5900
P577publication date1988-10-01
P1433published inCancer ResearchQ326097
P1476titleMechanisms of innate resistance to thymidylate synthase inhibition after 5-fluorouracil
P478volume48

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cites work (P2860)
Q372703565-Fluorouracil: mechanisms of resistance and reversal strategies
Q36691968Bcl-2/Bax protein ratio predicts 5-fluorouracil sensitivity independently of p53 status
Q67541455Biochemical modulation of 5-fluorouracil with or without leucovorin by a low dose of brequinar in MGH-U1 cells
Q34567805Cellular pharmacology of multi- and duplex drugs consisting of ethynylcytidine and 5-fluoro-2'-deoxyuridine
Q72368976Changes in folate concentration in Yoshida sarcoma after administration of leucovorin or cisplatin
Q38631279Clinical pharmacology of 5-fluorouracil
Q45113388Clinical significance of dihydropyrimidine dehydrogenase in adjuvant 5-fluorouracil liver perfusion chemotherapy for pancreatic cancer
Q72400006Comparative cytotoxicity of folate-based inhibitors of thymidylate synthase and 5-fluorouracil +/- leucovorin in MGH-U1 cells
Q31935218Determinants of prognosis and response to therapy in colorectal cancer
Q42108821Differential expression of cell cycle and apoptosis related proteins in colorectal mucosa, primary colon tumours, and liver metastases
Q36142392Effect of leucovorin on the antitumor efficacy of the 5-FU prodrug, tegafur-uracil, in human colorectal cancer xenografts with various expression levels of thymidylate synthase
Q39180988Enhancement of 5-fluorouracil-induced cytotoxicity by leucovorin in 5-fluorouracil-resistant gastric cancer cells with upregulated expression of thymidylate synthase
Q40275457Exploring the intracellular pharmacokinetics of the 5-fluorouracil nucleotides during capecitabine treatment.
Q36148634Folic Acid-Metabolizing Enzymes Regulate the Antitumor Effect of 5-Fluoro-2'-Deoxyuridine in Colorectal Cancer Cell Lines
Q41238678Folinic acid modulation of fluorouracil: tissue kinetics of bolus administration
Q71612879Histopathological response to preoperative chemotherapy including 5-fluorouracil additionally assessed by immunocytochemical and pharmacologic parameters in patients with advanced gastric cancer
Q41148056How to optimize the effect of 5-fluorouracil modulated therapy in advanced colorectal cancer
Q42389744In vitro antitumour activity of cis- and trans-5-fluoro-5,6-dihydro-6-alkoxy-uracils; effects on thymidylate synthesis
Q55334229In vivo antitumor effects of fluoropyrimidines on colon adenocarcinoma 38 and enhancement by leucovorin
Q39837916Integrating Dynamic Positron Emission Tomography and Conventional Pharmacokinetic Studies to Delineate Plasma and Tumor Pharmacokinetics of FAU, a Prodrug Bioactivated by Thymidylate Synthase
Q72575174Investigational Strategies for Detection and Intervention in Early-Stage Pancreatic Cancer. April 24-27, Annapolis, Maryland. Abstracts
Q70733006Metabolic basis of the synergistic antitumor activities of 5-fluorouracil and cisplatin in rodent tumor models in vivo
Q40390814New targets for pyrimidine antimetabolites in the treatment of solid tumours. 1: Thymidylate synthase
Q41234796Reduced activity of anabolizing enzymes in 5-fluorouracil-resistant human stomach cancer cells
Q71971495The effect of different routes of administration of 5-fluorouracil on thymidylate synthase inhibition in the rat
Q40423844Thymidylate synthase and drug resistance
Q38997864Usefulness of alternate-day administration of S-1 and leucovorin in a xenograft mouse model of colorectal cancer: a shorter drug-free interval leads to more efficient antitumor effects.

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