Inhibition of Src and forkhead box O1 signaling by induced pluripotent stem-cell therapy attenuates hyperoxia-augmented ventilator-induced diaphragm dysfunction

scientific article published on 22 March 2016

Inhibition of Src and forkhead box O1 signaling by induced pluripotent stem-cell therapy attenuates hyperoxia-augmented ventilator-induced diaphragm dysfunction is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.TRSL.2016.03.011
P8608Fatcat IDrelease_235hblx43jhtlicfovcdhanhcu
P698PubMed publication ID27055225

P50authorShih-Hwa ChiouQ91845706
Yuh-Lih ChangQ110698483
P2093author name stringNing-Hung Chen
Chih-Hao Chang
Meng-Chih Lin
Chung-Chi Huang
Gwo-Jyh Chang
Chien-Ying Wang
Jen-Hua Chuang
Yung-Yang Liu
Li-Fu Li
Yi-Pin Yang
P2860cites workInduced pluripotent stem cell lines derived from human somatic cellsQ27860597
Induction of pluripotent stem cells from adult human fibroblasts by defined factorsQ27860967
Reprogramming of human somatic cells to pluripotency with defined factorsQ28262710
Lumican expression in diaphragm induced by mechanical ventilationQ28514000
Antioxidant administration attenuates mechanical ventilation-induced rat diaphragm muscle atrophy independent of protein kinase B (PKB Akt) signallingQ28572937
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in miceQ29547898
Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophyQ29619282
Ros-mediated activation of NF-kappaB and Foxo during muscle disuseQ33551292
Improvement of ventilator-induced lung injury by IPS cell-derived conditioned medium via inhibition of PI3K/Akt pathway and IP-10-dependent paracrine regulation.Q54477847
Src tyrosine kinase inhibition prevents pulmonary ischemia-reperfusion-induced acute lung injury.Q54528581
Mechanical ventilation promotes redox status alterations in the diaphragmQ83289233
Toll-like receptor 4 signaling in ventilator-induced diaphragm atrophyQ84433305
Rapidly progressive diaphragmatic weakness and injury during mechanical ventilation in humansQ84976710
Oxidative stress is required for mechanical ventilation-induced protease activation in the diaphragm.Q33841166
Src-dependent impairment of autophagy by oxidative stress in a mouse model of Duchenne muscular dystrophyQ33913903
Apocynin attenuates diaphragm oxidative stress and protease activation during prolonged mechanical ventilationQ34016668
Discovery of Novel Forkhead Box O1 Inhibitors for Treating Type 2 Diabetes: Improvement of Fasting Glycemia in Diabetic db/db MiceQ34132966
Induced pluripotent stem cell therapy ameliorates hyperoxia-augmented ventilator-induced lung injury through suppressing the Src pathwayQ34332173
Mitochondrial dysfunction and lipid accumulation in the human diaphragm during mechanical ventilation.Q34424860
Increased proteolysis, myosin depletion, and atrophic AKT-FOXO signaling in human diaphragm disuseQ34665125
Suppressing NF-κB and NKRF Pathways by Induced Pluripotent Stem Cell Therapy in Mice with Ventilator-Induced Lung InjuryQ34805925
Intrinsic apoptosis in mechanically ventilated human diaphragm: linkage to a novel Fos/FoxO1/Stat3-Bim axis.Q35169490
Inhibition of forkhead boxO-specific transcription prevents mechanical ventilation-induced diaphragm dysfunction.Q35449812
Carbon monoxide activates autophagy via mitochondrial reactive oxygen species formationQ35528001
Prospects for clinical use of reprogrammed cells for autologous treatment of macular degenerationQ35608700
Caspase-3 regulation of diaphragm myonuclear domain during mechanical ventilation-induced atrophyQ35855171
Src protein tyrosine kinase family and acute inflammatory responses.Q36438267
Multiple pathways of cytochrome c release from mitochondria in apoptosisQ36470224
Poly(ADP-ribose) polymerase 1 regulates nuclear reprogramming and promotes iPSC generation without c-MycQ36547699
Oxidative stress and disuse muscle atrophyQ36731968
Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting.Q36765186
Ventilator-induced diaphragm dysfunction: the clinical relevance of animal modelsQ36967800
Pressure support ventilation attenuates ventilator-induced protein modifications in the diaphragm.Q36993117
Mitochondria-targeted antioxidants protect against mechanical ventilation-induced diaphragm weaknessQ37197868
Src mediates the mechanical activation of myogenesis by activating TNFα-converting enzymeQ37201493
Ventilator-induced diaphragm dysfunction: cause and effectQ38120655
Therapeutic potential and mechanisms of action of mesenchymal stromal cells for Acute Respiratory Distress SyndromeQ38192655
Rapid onset of specific diaphragm weakness in a healthy murine model of ventilator-induced diaphragmatic dysfunctionQ39590938
Ventilator-induced diaphragmatic dysfunctionQ39926522
The forkhead transcription factor FOXO4 sensitizes cancer cells to doxorubicin-mediated cytotoxicityQ39952894
Src-mediated tyrosine phosphorylation of p47phox in hyperoxia-induced activation of NADPH oxidase and generation of reactive oxygen species in lung endothelial cellsQ40445586
The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factorsQ40559475
A critical role for muscle ring finger-1 in acute lung injury-associated skeletal muscle wasting.Q42085122
FOXO transcription factors are mechanosensitive and their regulation is altered with aging in the respiratory pumpQ42524702
Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated from Patient iPSCsQ42581385
Multiple cellular electrophysiological effects of a novel antiarrhythmic furoquinoline derivative HA-7 [N-benzyl-7-methoxy-2,3,4,9-tetrahydrofuro[2,3-b]quinoline-3,4-dione] in guinea pig cardiac preparations.Q46365317
Mechanical ventilation-induced diaphragm disuse in humans triggers autophagyQ48123019
Functional improvement of focal cerebral ischemia injury by subdural transplantation of induced pluripotent stem cells with fibrin glueQ48288799
Mechanical ventilation results in progressive contractile dysfunction in the diaphragm.Q49138692
Mechanical ventilation-induced oxidative stress in the diaphragm.Q51296490
Relationship between Autophagy and Ventilator-induced Diaphragmatic Dysfunction.Q51305465
Attenuation of hyperoxia-induced diaphragmatic dysfunction with lidocaine in hamsters.Q51392250
P921main subjectventilatorQ813243
P304page(s)131-147.e1
P577publication date2016-03-22
P1433published inTranslational ResearchQ15761127
P1476titleInhibition of Src and forkhead box O1 signaling by induced pluripotent stem-cell therapy attenuates hyperoxia-augmented ventilator-induced diaphragm dysfunction
P478volume173

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cites work (P2860)
Q89170925Attenuation of ventilation-induced diaphragm dysfunction through toll-like receptor 4 and nuclear factor-κB in a murine endotoxemia model
Q90712405First-in-human high-cumulative-dose stem cell therapy in idiopathic pulmonary fibrosis with rapid lung function decline
Q37367228Intraoperative hemidiaphragm electrical stimulation reduces oxidative stress and upregulates autophagy in surgery patients undergoing mechanical ventilation: exploratory study
Q41138354Respiratory muscle dysfunction in animal models of hypoxic disease: antioxidant therapy goes from strength to strength.
Q93216038Ventilator-induced diaphragm dysfunction in critical illness