Iron homeostasis in astrocytes and microglia is differentially regulated by TNF-α and TGF-β1.

scientific article published in February 2012

Iron homeostasis in astrocytes and microglia is differentially regulated by TNF-α and TGF-β1. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/GLIA.22303
P698PubMed publication ID22298416

P2093author name stringSamuel David
Adriana Redensek
Khizr I Rathore
P2860cites workTGF-beta1 and TGF-beta2 expression after traumatic human spinal cord injuryQ24301515
The basics of epithelial-mesenchymal transitionQ24652992
An iron delivery pathway mediated by a lipocalinQ28216116
Iron is essential for neuron development and memory function in mouse hippocampusQ28586238
Iron, brain ageing and neurodegenerative disordersQ29615656
Physiological and pathological aspects of Abeta in iron homeostasis via 5'UTR in the APP mRNA and the therapeutic use of iron-chelatorsQ30855088
Brain iron pathways and their relevance to Parkinson's disease.Q33183051
Coordinate transcriptional and translational regulation of ferritin in response to oxidative stressQ33964988
Pathogenic implications of iron accumulation in multiple sclerosisQ34049616
Regulation of ferritin genes and proteinQ34126332
Ceruloplasmin metabolism and functionQ34132626
Tumor necrosis factor-alpha-induced iron sequestration and oxidative stress in human endothelial cellsQ34459491
Familial apoceruloplasmin deficiency associated with blepharospasm and retinal degenerationQ34690797
Iron mediates N-methyl-D-aspartate receptor-dependent stimulation of calcium-induced pathways and hippocampal synaptic plasticityQ34787203
Iron homeostasis and the inflammatory responseQ35024676
Iron status and neural functioningQ35110709
The pivotal role of astrocytes in the metabolism of iron in the brain.Q36841623
Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosisQ37241323
Iron is essential for oligodendrocyte genesis following intraspinal macrophage activationQ37243956
Oligodendrocytes and myelination: the role of ironQ37287582
Neuroinflammation in Huntington's diseaseQ37763886
Cytokine-mediated regulation of iron transport in human monocytic cellsQ38358858
Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophagesQ39595960
Neuroprotective and neuritogenic activities of novel multimodal iron-chelating drugs in motor-neuron-like NSC-34 cells and transgenic mouse model of amyotrophic lateral sclerosisQ39819811
Ferritin heavy chain-mediated iron homeostasis and subsequent increased reactive oxygen species production are essential for epithelial-mesenchymal transitionQ39837172
Interleukin-1beta up-regulates iron efflux in rat C6 glioma cells through modulation of ceruloplasmin and ferroportin-1 synthesisQ40550364
Characterization of a novel brain-derived microglial cell line isolated from neonatal rat brainQ40796632
Two routes of iron accumulation in astrocytes: ascorbate-dependent ferrous iron uptake via the divalent metal transporter (DMT1) plus an independent route for ferric iron.Q42916945
Ferritin induction protects cortical astrocytes from heme-mediated oxidative injuryQ44105509
Ceruloplasmin protects injured spinal cord from iron-mediated oxidative damage.Q44217143
Glycosylphosphatidylinositol-anchored ceruloplasmin is required for iron efflux from cells in the central nervous systemQ44438522
High-yield isolation of murine microglia by mild trypsinization.Q44645887
Iron accumulation, iron-mediated toxicity and altered levels of ferritin and transferrin receptor in cultured astrocytes during incubation with ferric ammonium citrate.Q44792347
Ferritin accumulation in dystrophic microglia is an early event in the development of Huntington's diseaseQ45305307
Dysregulation of iron homeostasis in the CNS contributes to disease progression in a mouse model of amyotrophic lateral sclerosis.Q45796087
Accumulation of non-transferrin-bound iron by neurons, astrocytes, and microglia.Q48218695
Age-related changes in iron homeostasis and cell death in the cerebellum of ceruloplasmin-deficient mice.Q48416862
Cellular iron status influences the functional relationship between microglia and oligodendrocytesQ48426970
H and L ferritin subunit mRNA expression differs in brains of control and iron-deficient ratsQ48489234
Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury.Q48525934
Quantitative assessment of brain iron by R(2)* relaxometry in patients with clinically isolated syndrome and relapsing-remitting multiple sclerosisQ48553203
Expression of pro-inflammatory cytokine and chemokine mRNA upon experimental spinal cord injury in mouse: an in situ hybridization studyQ48669034
Iron deposits in multiple sclerosis and Alzheimer's disease brainsQ48682014
Proinflammatory cytokine synthesis in the injured mouse spinal cord: multiphasic expression pattern and identification of the cell types involved.Q50707768
Analysis of TGF-beta 1 gene expression in contused rat spinal cord using quantitative RT-PCRQ71350463
Localization of transforming growth factor-beta1 and receptor mRNA after experimental spinal cord injuryQ73721201
Interleukin-1beta increases binding of the iron regulatory protein and the synthesis of ferritin by increasing the labile iron poolQ74342059
P433issue5
P921main subjectastrocyteQ502961
microgliaQ1622829
TNFQ18032037
P304page(s)738-750
P577publication date2012-02-01
P1433published inGliaQ15716658
P1476titleIron homeostasis in astrocytes and microglia is differentially regulated by TNF-α and TGF-β1.
P478volume60

Reverse relations

cites work (P2860)
Q92339420Acupuncture protects from 6-OHDA-induced neuronal damage by balancing the ratio of DMT1/Fpn1
Q90265033Allicin attenuated chronic social defeat stress induced depressive-like behaviors through suppression of NLRP3 inflammasome
Q47144038Anti-inflammatory effect of delphinidin on intramedullary spinal pressure in a spinal cord injury rat model
Q28393397Astrocytes acquire resistance to iron-dependent oxidative stress upon proinflammatory activation
Q60916503Ceruloplasmin Plays a Neuroprotective Role in Cerebral Ischemia
Q54113689Could Alzheimer's Disease Originate in the Periphery and If So How So?
Q37423548Dissociation between iron accumulation and ferritin upregulation in the aged substantia nigra: attenuation by dietary restriction.
Q49885816Hepcidin, an emerging and important player in brain iron homeostasis
Q36456665In Vivo MRI Mapping of Brain Iron Deposition across the Adult Lifespan
Q28572077Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells
Q28391762Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease
Q91681698Iron Dyshomeostasis Induces Binding of APP to BACE1 for Amyloid Pathology, and Impairs APP/Fpn1 Complex in Microglia: Implication in Pathogenesis of Cerebral Microbleeds
Q64107531Iron Exposure and the Cellular Mechanisms Linked to Neuron Degeneration in Adult Mice
Q35023030Iron accumulates in Huntington's disease neurons: protection by deferoxamine
Q38052479Iron accumulation in Parkinson's disease
Q34470577Iron and neurodegeneration in the multiple sclerosis brain
Q27001743Iron chelation and multiple sclerosis
Q26829932Iron dysregulation in Huntington's disease
Q26825777Iron entry in neurons and astrocytes: a link with synaptic activity
Q64076840Iron in Neurodegeneration - Cause or Consequence?
Q42961777Iron uptake in quiescent and inflammation-activated astrocytes: a potentially neuroprotective control of iron burden
Q59799012Lipocalin 2 contributes to brain iron dysregulation but does not affect cognition, plaque load, and glial activation in the J20 Alzheimer mouse model
Q34153515Lipocalin 2 modulates the cellular response to amyloid beta.
Q38842617Lysosomal iron liberation is responsible for the vulnerability of brain microglial cells to iron oxide nanoparticles: comparison with neurons and astrocytes.
Q54985162Mechanisms of Endogenous Neuroprotective Effects of Astrocytes in Brain Injury.
Q91529318Multi-copper ferroxidase deficiency leads to iron accumulation and oxidative damage in astrocytes and oligodendrocytes
Q49324255New Progress on the Role of Glia in Iron Metabolism and Iron-Induced Degeneration of Dopamine Neurons in Parkinson's Disease
Q33841090Pathogenic implications of distinct patterns of iron and zinc in chronic MS lesions
Q27301306Pharmacological Suppression of CNS Scarring by Deferoxamine Reduces Lesion Volume and Increases Regeneration in an In Vitro Model for Astroglial-Fibrotic Scarring and in Rat Spinal Cord Injury In Vivo
Q92535602Regional Distributions of Iron, Copper and Zinc and Their Relationships With Glia in a Normal Aging Mouse Model
Q93038045Regulation of tissue iron homeostasis: the macrophage "ferrostat"
Q31038817Role of iron in neurodegenerative diseases
Q37390184Significant glial alterations in response to iron loading in a novel organotypic hippocampal slice culture model
Q38751696TGF-β signaling directly regulates transcription and functional expression of the electrogenic sodium bicarbonate cotransporter 1, NBCe1 (SLC4A4), via Smad4 in mouse astrocytes.
Q38175970The effect of glia-glia interactions on oligodendrocyte precursor cell biology during development and in demyelinating diseases
Q30852753The role of iron in brain ageing and neurodegenerative disorders.
Q37485028The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer's disease

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