Dendritic cell vaccines based on immunogenic cell death elicit danger signals and T cell-driven rejection of high-grade glioma

scientific article published in March 2016

Dendritic cell vaccines based on immunogenic cell death elicit danger signals and T cell-driven rejection of high-grade glioma is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1126/SCITRANSLMED.AAE0105
P698PubMed publication ID26936504
P5875ResearchGate publication ID296668321

P50authorPatrizia AgostinisQ30111808
Abhishek D. GargQ38322540
Louis BoonQ89457618
Stefaan Van GoolQ96142102
Carolien A M KoksQ114531668
Lien VandenberkQ114575324
Tina VerschuereQ114575350
P2860cites workThe Cancer Genome Atlas Pan-Cancer analysis projectQ24606808
A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell deathQ24620548
Comprehensive genomic characterization defines human glioblastoma genes and core pathwaysQ24656128
Clinical efficacy of tumor antigen-pulsed DC treatment for high-grade glioma patients: evidence from a meta-analysisQ27348437
The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics dataQ28266682
Calreticulin exposure dictates the immunogenicity of cancer cell deathQ28280438
The somatic genomic landscape of glioblastomaQ28300185
Monitoring of regulatory T cell frequencies and expression of CTLA-4 on T cells, before and after DC vaccination, can predict survival in GBM patientsQ28730798
Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trialQ29547224
Java Treeview--extensible visualization of microarray dataQ29547226
Open source clustering softwareQ29547702
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapyQ29619961
Immunogenic Cell Death in Cancer TherapyQ29620118
The immune contexture in human tumours: impact on clinical outcomeQ29620667
Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in miceQ30493889
Immunocompetent murine models for the study of glioblastoma immunotherapyQ33574853
Immunological factors relating to the antitumor effect of temozolomide chemoimmunotherapy in a murine glioma modelQ33613430
Tumour-infiltrating CD4(+) and CD8(+) lymphocytes as predictors of clinical outcome in gliomaQ33613584
Prognostic value of the preoperative immunological profile in patients with glioblastomaQ33887213
Tumour-infiltrating T-cell subpopulations in glioblastomasQ33943553
Dendritic-cell-based therapeutic cancer vaccinesQ34360094
Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapyQ34399765
Clinical use of dendritic cells for cancer therapy.Q34421850
Predicting the "usefulness" of 5-ALA-derived tumor fluorescence for fluorescence-guided resections in pediatric brain tumors: a European surveyQ34515718
CD8+ T-cell infiltrate in newly diagnosed glioblastoma is associated with long-term survival.Q34721530
Impact of Tumour Volume on the Potential Efficacy of Therapeutic VaccinesQ35027034
Immunosuppression in Patients with High-Grade Gliomas Treated with Radiation and TemozolomideQ35167257
PROGgeneV2: enhancements on the existing databaseQ35527541
Dendritic Cell-Based Vaccines that Utilize Myeloid Rather than Plasmacytoid Cells Offer a Superior Survival Advantage in Malignant Glioma.Q35763478
Pre-treatment neutrophil-to-lymphocyte ratio is associated with neutrophil and T-cell infiltration and predicts clinical outcome in patients with glioblastomaQ35765180
Regulatory T cells are not a strong predictor of survival for patients with glioblastomaQ35789008
Programmed death ligand 1 expression and tumor-infiltrating lymphocytes in glioblastomaQ35815273
Meta-analysis of organ-specific differences in the structure of the immune infiltrate in major malignanciesQ35828467
Dexamethasone exerts profound immunologic interference on treatment efficacy for recurrent glioblastomaQ35863183
Shikonin-enhanced cell immunogenicity of tumor vaccine is mediated by the differential effects of DAMP componentsQ36092658
Molecular and Translational Classifications of DAMPs in Immunogenic Cell DeathQ36301061
PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stressQ36311137
Impact of temozolomide on immune response during malignant glioma chemotherapyQ36362798
Resistance to anticancer vaccination effect is controlled by a cancer cell-autonomous phenotype that disrupts immunogenic phagocytic removalQ36413628
Epigenetic biomarkers of T-cells in human glioma.Q36484129
Analysis of CD137L and IL-17 Expression in Tumor Tissue as Prognostic Indicators for GliblastomaQ36609839
Increased proportion of FoxP3+ regulatory T cells in tumor infiltrating lymphocytes is associated with tumor recurrence and reduced survival in patients with glioblastoma.Q36639475
The prognostic landscape of genes and infiltrating immune cells across human cancersQ36857285
Immunological responses in a patient with glioblastoma multiforme treated with sequential courses of temozolomide and immunotherapy: case studyQ37011021
Immune response in patients with newly diagnosed glioblastoma multiforme treated with intranodal autologous tumor lysate-dendritic cell vaccination after radiation chemotherapy.Q37154132
Danger signalling during cancer cell death: origins, plasticity and regulation.Q37381745
DC vaccination with anti-CD25 treatment leads to long-term immunity against experimental glioma.Q37395354
Immune heterogeneity of glioblastoma subtypes: extrapolation from the cancer genome atlasQ37435455
The prognostic value of Foxp3+ tumor-infiltrating lymphocytes in patients with glioblastomaQ37471704
Dendritic cell therapy of high-grade gliomas.Q37594834
MyD88: A Critical Adaptor Protein in Innate Immunity Signal TransductionQ38069571
From the immune contexture to the Immunoscore: the role of prognostic and predictive immune markers in cancerQ38098366
Immature, Semi-Mature, and Fully Mature Dendritic Cells: Toward a DC-Cancer Cells Interface That Augments Anticancer ImmunityQ38174601
Targeting adaptive glioblastoma: an overview of proliferation and invasionQ38235930
Active dendritic cell immunotherapy for glioblastoma: Current status and challengesQ38301084
BNIP3 supports melanoma cell migration and vasculogenic mimicry by orchestrating the actin cytoskeletonQ38593285
ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell deathQ39135022
Role of endoplasmic reticulum depletion and multidomain proapoptotic BAX and BAK proteins in shaping cell death after hypericin-mediated photodynamic therapyQ40321304
Antitumor immunity triggered by melphalan is potentiated by melanoma cell surface-associated calreticulinQ41436818
Issues in experimental design and endpoint analysis in the study of experimental cytotoxic agents in vivo in breast cancer and other models.Q41710325
Newcastle disease virotherapy induces long-term survival and tumor-specific immune memory in orthotopic glioma through the induction of immunogenic cell deathQ41744540
Development and validation of a fully GMP-compliant production process of autologous, tumor-lysate-pulsed dendritic cells.Q42218510
Photodynamic therapy of nonmelanoma skin cancer with topical hypericum perforatum extract--a pilot studyQ42523363
A phase II placebo-controlled study of photodynamic therapy with topical hypericin and visible light irradiation in the treatment of cutaneous T-cell lymphoma and psoriasisQ42871258
Glioma-derived galectin-1 regulates innate and adaptive antitumor immunity.Q45945651
Elevated CD3+ and CD8+ tumor-infiltrating immune cells correlate with prolonged survival in glioblastoma patients despite integrated immunosuppressive mechanisms in the tumor microenvironment and at the systemic levelQ46459126
Prognostic significance and mechanism of Treg infiltration in human brain tumors.Q48170914
CD4+ CD25+ FoxP3+ T-cell infiltration and heme oxygenase-1 expression correlate with tumor grade in human gliomasQ48313295
Dendritic cell vaccination combined with temozolomide retreatment: results of a phase I trial in patients with recurrent glioblastoma multiformeQ48467671
Hypericin for visualization of high grade gliomas: first clinical experienceQ48689562
Incidence and prognostic impact of FoxP3+ regulatory T cells in human gliomas.Q48973528
Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer.Q54618275
Effector T-cell infiltration positively impacts survival of glioblastoma patients and is impaired by tumor-derived TGF-β.Q55463248
NF-kappaB inhibition improves the sensitivity of human glioblastoma cells to 5-aminolevulinic acid-based photodynamic therapy.Q55463555
Enhanced antitumour immunity by combined use of temozolomide and TAT-survivin pulsed dendritic cells in a murine glioma.Q55467906
Hypericin-induced photosensitization of HeLa cells leads to apoptosis or necrosisQ56993328
Shikonin induces immunogenic cell death in tumor cells and enhances dendritic cell-based cancer vaccineQ58032919
P433issue328
P407language of work or nameEnglishQ1860
P921main subjectcell deathQ2383867
dendritic cellQ506253
P304page(s)328ra27
P577publication date2016-03-01
P1433published inScience Translational MedicineQ1573955
P1476titleDendritic cell vaccines based on immunogenic cell death elicit danger signals and T cell-driven rejection of high-grade glioma
P478volume8

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cites work (P2860)
Q44876957A melanin-mediated cancer immunotherapy patch
Q38921652Advances and challenges: dendritic cell vaccination strategies for glioblastoma.
Q47569046Advances in immunotherapeutic research for glioma therapy.
Q28078649Autophagy-Dependent Secretion: Contribution to Tumor Progression
Q28067203Boosting Tumor-Specific Immunity Using PDT
Q45160319Caspase-2 and oxidative stress underlie the immunogenic potential of high hydrostatic pressure-induced cancer cell death.
Q47614555Cell death and immunity in cancer: From danger signals to mimicry of pathogen defense responses.
Q50433335Collagen I enhances the efficiency and anti-tumor activity of dendritic-tumor fusion cells
Q38708463Computed determination of the in vitro optimal chemocombinations of sphaeropsidin A with chemotherapeutic agents to combat melanomas
Q90629204Consensus guidelines for the definition, detection and interpretation of immunogenic cell death
Q92263929Cytomegalovirus promotes murine glioblastoma growth via pericyte recruitment and angiogenesis
Q38928826DAMP-Induced Allograft and Tumor Rejection: The Circle Is Closing.
Q49679692Defining the role of the tumor vasculature in antitumor immunity and immunotherapy
Q90362022Dendritic Cells and Immunogenic Cancer Cell Death: A Combination for Improving Antitumor Immunity
Q36201736Dendritic cell immunotherapy versus bevacizumab plus irinotecan in recurrent malignant glioma patients: a survival gain analysis
Q89347786Dendritic cell-based immunotherapy
Q92995626Dendritic cells in cancer immunology and immunotherapy
Q38851464Developing immunotherapeutic strategies to target brain tumors
Q57817490Diamonds in the Rough: Harnessing Tumor-Associated Myeloid Cells for Cancer Therapy
Q49370635Drug-induced ciliogenesis in pancreatic cancer cells is facilitated by the secreted ATP-purinergic receptor signaling pathway
Q47233214E3L and F1L Gene Functions Modulate the Protective Capacity of Modified Vaccinia Virus Ankara Immunization in Murine Model of Human Smallpox
Q39585070Editorial: Immunogenic Cell Death in Cancer: From Benchside Research to Bedside Reality
Q39441238Emerging Role of the Unfolded Protein Response in Tumor Immunosurveillance.
Q39381281Engineering challenges for brain tumor immunotherapy
Q55190117Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges.
Q59135320Exosomes derived from rAAV/AFP-transfected dendritic cells elicit specific T cell-mediated immune responses against hepatocellular carcinoma
Q50566797Exploiting a new strategy to induce immunogenic cell death to improve dendritic cell-based vaccines for lymphoma immunotherapy
Q33594333Fusions of Tumor-derived Endothelial Cells with Dendritic Cells Induces Antitumor Immunity
Q92626019Honokiol-enhanced cytotoxic T lymphocyte activity against cholangiocarcinoma cells mediated by dendritic cells pulsed with damage-associated molecular patterns
Q97531602Immune system activation by natural products and complex fractions: a network pharmacology approach in cancer treatment
Q49805006Immunogenic Apoptosis as a Novel Tool for Anticancer Vaccine Development.
Q64107945Immunogenic Cell Death and Immunotherapy of Multiple Myeloma
Q92835955Immunogenic cell death in cancer therapy: Present and emerging inducers
Q42378527Immunomodulatory and antitumor effects of type I interferons and their application in cancer therapy
Q98223086Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors
Q90656057Immunotherapeutic strategies for treatment of hepatocellular carcinoma with antigen-loaded dendritic cells: in vivo study
Q42639856Immunotherapy with subcutaneous immunogenic autologous tumor lysate increases murine glioblastoma survival
Q48170351Intratumoral delivery of tumor antigen-loaded DC and tumor-primed CD4+ T cells combined with agonist α-GITR mAb promotes durable CD8+ T-cell-dependent antitumor immunity
Q90697648Local Phototherapy Synergizes with Immunoadjuvant for Treatment of Pancreatic Cancer through Induced Immunogenic Tumor Vaccine
Q90053615Low Photosensitizer Dose and Early Radiotherapy Enhance Antitumor Immune Response of Photodynamic Therapy-Based Dendritic Cell Vaccination
Q48344360Metronomic treatment in immunocompetent preclinical GL261 glioblastoma: effects of cyclophosphamide and temozolomide
Q47843948Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
Q98159129Nanomicelle protects the immune activation effects of Paclitaxel and sensitizes tumors to anti-PD-1 Immunotherapy
Q40319033Pathogen response-like recruitment and activation of neutrophils by sterile immunogenic dying cells drives neutrophil-mediated residual cell killing
Q90021097Photodynamic Therapy and Immunity: An Update
Q89975467Photodynamic Therapy-Based Dendritic Cell Vaccination Suited to Treat Peritoneal Mesothelioma
Q64890734Photodynamic therapy mediated immune therapy of brain tumors.
Q98726595Photodynamic therapy regulates fate of cancer stem cells through reactive oxygen species
Q88885196Photodynamic therapy with redaporfin targets the endoplasmic reticulum and Golgi apparatus
Q33809573Phytochemicals Approach for Developing Cancer Immunotherapeutics
Q38438763Preclinical efficacy of immune-checkpoint monotherapy does not recapitulate corresponding biomarkers-based clinical predictions in glioblastoma.
Q60914597Recent Advances in Oncolytic Virotherapy and Immunotherapy for Glioblastoma: A Glimmer of Hope in the Search for an Effective Therapy?
Q33683101Sensitization of glioblastoma tumor micro-environment to chemo- and immunotherapy by Galectin-1 intranasal knock-down strategy
Q64057061Strategies for developing and optimizing cancer vaccines
Q47745185Strategies to Improve Vaccine Efficacy against Tuberculosis by Targeting Innate Immunity
Q47135720Strategies to Improve the Efficacy of Dendritic Cell-Based Immunotherapy for Melanoma
Q92598503Synthetic lethality between VPS4A and VPS4B triggers an inflammatory response in colorectal cancer
Q90646039The Course of Immune Stimulation by Photodynamic Therapy: Bridging Fundamentals of Photochemically Induced Immunogenic Cell Death to the Enrichment of T-Cell Repertoire
Q91828247The Destruction Of Laser-Induced Phase-Transition Nanoparticles Triggered By Low-Intensity Ultrasound: An Innovative Modality To Enhance The Immunological Treatment Of Ovarian Cancer Cells
Q39178065The Microenvironmental Landscape of Brain Tumors
Q38930244The Role of Immune Checkpoint Inhibition in the Treatment of Brain Tumors
Q47863483The Unfolded Protein Response in Immunogenic Cell Death and Cancer Immunotherapy
Q53109846Trial watch: Dendritic cell-based anticancer immunotherapy
Q56594845Trial watch: Immunogenic cell death induction by anticancer chemotherapeutics
Q89457645Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology
Q90080201Type I interferons and endoplasmic reticulum stress in health and disease
Q40081800Uncovering the immunotherapeutic cycle initiated by p19Arf and interferon-β gene transfer to cancer cells: An inducer of immunogenic cell death

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