CYP3A induction and inhibition by different antiretroviral regimens reflected by changes in plasma 4beta-hydroxycholesterol levels

scientific article published on 6 May 2008

CYP3A induction and inhibition by different antiretroviral regimens reflected by changes in plasma 4beta-hydroxycholesterol levels is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00228-008-0492-8
P698PubMed publication ID18458892

P50authorUlf DiczfalusyQ42813198
P2093author name stringA Sönnerborg
M Gisslén
V Ormaasen
L Bertilsson
Y Böttiger
L Flamholc
F Josephson
P2860cites workUrinary 6?-hydroxycortisol: a validated test for evaluating drug induction or drug inhibition mediated through CYP3A in humans and in animalsQ35579020
Metabolism of 4 beta -hydroxycholesterol in humans.Q40723392
Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4.Q40784945
4Beta-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and TanzaniansQ43944775
Hepatic but not intestinal CYP3A4 displays dose-dependent induction by efavirenz in humansQ44085569
Lopinavir: acute exposure inhibits P-glycoprotein; extended exposure induces P-glycoproteinQ44406923
Impact of the CYP3A5 genotype on midazolam pharmacokinetics and pharmacodynamics during intensive care sedationQ48567513
Lopinavir/ritonavir induces the hepatic activity of cytochrome P450 enzymes CYP2C9, CYP2C19, and CYP1A2 but inhibits the hepatic and intestinal activity of CYP3A as measured by a phenotyping drug cocktail in healthy volunteersQ48705073
The oxysterols cholest-5-ene-3 beta,4 alpha-diol, cholest-5-ene-3 beta,4 beta-diol and cholestane-3 beta,5 alpha,6 alpha-triol are formed during in vitro oxidation of low density lipoprotein, and are present in human atherosclerotic plaquesQ59307014
Identification and quantitation of cholest-5-ene-3 beta,4 beta-diol in rat liver and human plasmaQ71131941
Ritonavir. Clinical pharmacokinetics and interactions with other anti-HIV agentsQ77542483
Metabolic effects of protease inhibitor-sparing antiretroviral regimens given as initial treatment of HIV-1 Infection (AIDS Clinical Trials Group Study A5095)Q79633442
Lopinavir/ritonavir reduces lamotrigine plasma concentrations in healthy subjectsQ80063643
P433issue8
P304page(s)775-781
P577publication date2008-05-06
P1433published inEuropean Journal of Clinical PharmacologyQ1376707
P1476titleCYP3A induction and inhibition by different antiretroviral regimens reflected by changes in plasma 4beta-hydroxycholesterol levels
P478volume64