Inhibition of glutamine synthetase triggers apoptosis in asparaginase-resistant cells

scientific article published in January 2005

Inhibition of glutamine synthetase triggers apoptosis in asparaginase-resistant cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1159/000087238
P698PubMed publication ID16037693

P50authorOvidio BussolatiQ39567960
Amelia BarilliQ39993547
Bianca Maria RotoliQ124178628
P2093author name stringRita Gatti
Gian C Gazzola
Valeria Dall'Asta
Guido Orlandini
Jacopo Uggeri
Rossana Visigalli
P2860cites workStem cells, cancer, and cancer stem cellsQ27860878
Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assaysQ28140044
Wnt signaling in B-cell neoplasiaQ28182311
Asparagine synthetase expression alone is sufficient to induce l-asparaginase resistance in MOLT-4 human leukaemia cellsQ28367265
Establishment of real-time polymerase chain reaction method for quantitative analysis of asparagine synthetase expressionQ35790343
Activation of the Wnt signaling pathway in chronic lymphocytic leukemiaQ36854046
Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.Q38343552
A modified radioisotopic assay for measuring glutamine synthetase activity in tissue extractsQ39261130
Rapid induction of the intrinsic apoptotic pathway by L-glutamine starvationQ40511549
Comparison of annexin V and calcein-AM as early vital markers of apoptosis in adherent cells by confocal laser microscopy.Q41023441
Glutamine regulates glutamine synthetase expression in skeletal muscle cells in cultureQ41717087
Molecular and genetic characterization of human cell lines resistant to L-asparaginase and albizziinQ41756370
A splice variant acquiring an extra transcript leader region decreases the translation of glutamine synthetase geneQ42157146
Characterization of apoptotic phenomena induced by treatment with L-asparaginase in NIH3T3 cells.Q42824095
Suppression of anionic amino acid transport impairs the maintenance of intracellular glutamate in Ha-ras-expressing cellsQ42826665
Glutamine deprivation-mediated cell shrinkage induces ligand-independent CD95 receptor signaling and apoptosisQ43765047
Sensitivity to L-asparaginase is not associated with expression levels of asparagine synthetase in t(12;21)+ pediatric ALL.Q44217783
New targets of beta-catenin signaling in the liver are involved in the glutamine metabolismQ44226601
Upstream and intronic regulatory sequences interact in the activation of the glutamine synthetase promoterQ44328134
Upregulation of asparagine synthetase fails to avert cell cycle arrest induced by L-asparaginase in TEL/AML1-positive leukaemic cells.Q44729078
Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatmentQ45007602
A silencer element in the regulatory region of glutamine synthetase controls cell type-specific repression of gene induction by glucocorticoidsQ47973727
Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridineQ56879285
P433issue6
P304page(s)281-292
P577publication date2005-01-01
P1433published inCellular Physiology and BiochemistryQ2229420
P1476titleInhibition of glutamine synthetase triggers apoptosis in asparaginase-resistant cells
P478volume15

Reverse relations

cites work (P2860)
Q61799801Assessment of l-Asparaginase Pharmacodynamics in Mouse Models of Cancer
Q41427021Binding of nickel to testicular glutamate-ammonia ligase inhibits its enzymatic activity
Q26775475Cancer metabolism and oxidative stress: Insights into carcinogenesis and chemotherapy via the non-dihydrofolate reductase effects of methotrexate
Q36944183Cell volume regulatory ion channels in cell proliferation and cell death
Q33749811Cell-cycle inhibition by Helicobacter pylori L-asparaginase
Q38915906Differential mechanisms of asparaginase resistance in B-type acute lymphoblastic leukemia and malignant natural killer cell lines
Q38657061Drug-induced amino acid deprivation as strategy for cancer therapy
Q38970692Glutamine depletion by crisantaspase hinders the growth of human hepatocellular carcinoma xenografts
Q54512482Glutamine stimulates mTORC1 independent of the cell content of essential amino acids.
Q24318220Glutamine synthetase is essential for proliferation of fetal skin fibroblasts
Q31043770Inborn error of amino acid synthesis: human glutamine synthetase deficiency
Q37311260Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia.
Q36345950Ion channels in cell proliferation and apoptotic cell death
Q46518378Pharmacokinetic, pharmacodynamic and intracellular effects of PEG-asparaginase in newly diagnosed childhood acute lymphoblastic leukemia: results from a single agent window study
Q38994917Pharmacology, immunogenicity, and efficacy of a novel pegylated recombinant Erwinia chrysanthemi-derived L-asparaginase
Q46979018Reduced Ca2+ entry and suicidal death of erythrocytes in PDK1 hypomorphic mice
Q54457075Role of glutamine depletion in directing tissue-specific nutrient stress responses to L-asparaginase.
Q38110755Role of ion transport in control of apoptotic cell death
Q30497031The eIF2 Kinase GCN2 Is Essential for the Murine Immune System to Adapt to Amino Acid Deprivation by Asparaginase
Q37341948The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment.
Q54573293The non-proteinogenic amino acids L-methionine sulfoximine and DL-phosphinothricin activate mTOR.
Q87924791[Expression of asparagine synthetase in relapsed or refractory extranodal NK/T cell lymphoma]

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