PS-341 and gemcitabine in patients with metastatic pancreatic adenocarcinoma: a North Central Cancer Treatment Group (NCCTG) randomized phase II study

scientific article published on 5 August 2005

PS-341 and gemcitabine in patients with metastatic pancreatic adenocarcinoma: a North Central Cancer Treatment Group (NCCTG) randomized phase II study is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/ANNONC/MDI324
P698PubMed publication ID16085692
P5875ResearchGate publication ID7673923

P50authorSteven R AlbertsQ88846398
P2093author name stringS Gill
M Wiesenfeld
J Kugler
P Steen
T R Fitch
P Schaefer
R F Morton
N R Foster
G P Kim
P2860cites workIncreased expression of NF-kappa B subunits in human pancreatic cancer cellsQ40565497
Chemosensitization of pancreatic cancer by inhibition of the 26S proteasomeQ43715004
Schedule-dependent molecular effects of the proteasome inhibitor bortezomib and gemcitabine in pancreatic cancerQ44565471
Phase I trial of the proteasome inhibitor bortezomib in patients with advanced solid tumors with observations in androgen-independent prostate cancerQ44915315
Phase II trial of bortezomib for patients with advanced renal cell carcinomaQ45057193
An analysis of variance test for normality (complete samples)Q57253423
Nonparametric Estimation from Incomplete ObservationsQ25938997
New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of CanadaQ27860904
Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trialQ29547565
Phase II study of the proteasome inhibitor bortezomib (PS-341) in patients with metastatic neuroendocrine tumorsQ33151848
Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignanciesQ33345317
A phase 2 study of bortezomib in relapsed, refractory myelomaQ33348702
Phase II trial of PS-341 in patients with renal cell cancer: a University of Chicago phase II consortium studyQ33358394
26S proteasome inhibition induces apoptosis and limits growth of human pancreatic cancerQ33950784
Development of the proteasome inhibitor Velcade (Bortezomib).Q34327233
Preclinical and clinical evaluation of proteasome inhibitor PS-341 for the treatment of cancerQ34754670
P433issue10
P921main subjectadenocarcinomaQ356033
pancreatic adenocarcinomaQ18556189
metastatic pancreatic adenocarcinomaQ19000961
P304page(s)1654-1661
P577publication date2005-08-05
P1433published inAnnals of OncologyQ326122
P1476titlePS-341 and gemcitabine in patients with metastatic pancreatic adenocarcinoma: a North Central Cancer Treatment Group (NCCTG) randomized phase II study
P478volume16

Reverse relations

cites work (P2860)
Q33375650A Phase II study of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) and gemcitabine in advanced pancreatic carcinoma. A trial of the Princess Margaret hospital Phase II consortium
Q33394153A phase II study of bortezomib and gemcitabine in relapsed mantle cell lymphoma from the National Cancer Institute of Canada Clinical Trials Group (IND 172).
Q39958680Active roles for inhibitory kappaB kinases alpha and beta in nuclear factor-kappaB-mediated chemoresistance to doxorubicin
Q33391857An international, multicenter phase II trial of bortezomib in patients with hepatocellular carcinoma.
Q37326210Bortezomib and gemcitabine in relapsed or refractory Hodgkin's lymphoma.
Q36529784Bortezomib: efficacy comparisons in solid tumors and hematologic malignancies.
Q52647259Chemotherapy and radiotherapy for advanced pancreatic cancer.
Q24240739Chemotherapy and radiotherapy for inoperable advanced pancreatic cancer
Q24245085Chemotherapy and radiotherapy for inoperable advanced pancreatic cancer
Q37136598Clinical development of novel proteasome inhibitors for cancer treatment
Q34372977Combined autophagy and proteasome inhibition: a phase 1 trial of hydroxychloroquine and bortezomib in patients with relapsed/refractory myeloma
Q37344586Differential bortezomib sensitivity in head and neck cancer lines corresponds to proteasome, nuclear factor-kappaB and activator protein-1 related mechanisms.
Q38352184Effect of NF-κB inhibition on chemoresistance in biliary-pancreatic cancer.
Q38258843Efficacy of therapy with bortezomib in solid tumors: a review based on 32 clinical trials
Q36989921Emerging drugs for biliary cancer
Q36866617Emerging drugs for the treatment of pancreatic cancer
Q28533949From bench to bedside: lessons learned in translating preclinical studies in cancer drug development
Q64064242Genome-wide CRISPR screen reveals PSMA6 to be an essential gene in pancreatic cancer cells
Q34976755Historical controls for metastatic pancreatic cancer: benchmarks for planning and analyzing single-arm phase II trials
Q37017342Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trials
Q36758436Molecular mechanisms of pancreatic cancer and potential targets of treatment
Q37996435NF-κB as a target for pancreatic cancer therapy.
Q38002469New targeted approaches against the ubiquitin-proteasome system in gastrointestinal malignancies
Q37614590Novel agents for the treatment of adenocarcinoma of the pancreas
Q37107622Novel therapies for pancreatic cancer: setbacks and progress
Q36623071Pancreatic cancer: a review of recent advances
Q33899954Pancreatic cancer: molecular pathogenesis and new therapeutic targets
Q42098281Peroxisome proliferator-activated receptor gamma and regulations by the ubiquitin-proteasome system in pancreatic cancer
Q37327280Pharmacokinetics and safety of bortezomib in patients with advanced malignancies and varying degrees of liver dysfunction: phase I NCI Organ Dysfunction Working Group Study NCI-6432.
Q52720471Pomalidomide promotes chemosensitization of pancreatic cancer by inhibition of NF-κB.
Q37449396Proteasome inhibition enhances antitumour effects of gemcitabine in experimental pancreatic cancer
Q46033964Proteasome inhibitor MG132 inhibits angiogenesis in pancreatic cancer by blocking NF-kappaB activity.
Q50304177Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3-MYC Interactions as a Target in Pancreatic Cancer
Q35076238Systemic therapy for metastatic pancreatic adenocarcinoma
Q36678582Systems biology-defined NF-kappaB regulons, interacting signal pathways and networks are implicated in the malignant phenotype of head and neck cancer cell lines differing in p53 status
Q33899923Targeted therapies for pancreatic cancer
Q37004739Targeting apoptosis in solid tumors: the role of bortezomib from preclinical to clinical evidence.
Q37709559The development and pharmacology of proteasome inhibitors for the management and treatment of cancer
Q38211076The role of inflammation in pancreatic cancer
Q33916030The ubiquitin-proteasome system as a molecular target in solid tumors: an update on bortezomib.
Q47420926Xanthohumol inhibits angiogenesis by suppressing nuclear factor-κB activation in pancreatic cancer.

Search more.