The role of liver and kidney on the pharmacokinetics of a recombinant amino terminal fragment of bactericidal/permeability-increasing protein in rats

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The role of liver and kidney on the pharmacokinetics of a recombinant amino terminal fragment of bactericidal/permeability-increasing protein in rats is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1023/A:1012013113759
P698PubMed publication ID9090714

P2093author name stringA H Kung
R J Bauer
J Barrientos
K Der
N Ottah-Ihejeto
P2860cites workCloning of the cDNA of a human neutrophil bactericidal protein. Structural and functional correlationsQ24339484
Human bactericidal/permeability-increasing protein and a recombinant NH2-terminal fragment cause killing of serum-resistant gram-negative bacteria in whole blood and inhibit tumor necrosis factor release induced by the bacteriaQ35822718
Heparin affinity of anionic and cationic capillary endothelial cell growth factors: analysis of hypothalamus-derived growth factors and fibroblast growth factorsQ37676846
Septic shock in humans. Advances in the understanding of pathogenesis, cardiovascular dysfunction, and therapyQ37943123
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High-affinity binding of the bactericidal/permeability-increasing protein and a recombinant amino-terminal fragment to the lipid A region of lipopolysaccharideQ40152200
Bactericidal/permeability-increasing protein ameliorates acute lung injury in porcine endotoxemiaQ43474863
Recombinant amino terminal fragment of bactericidal/permeability-increasing protein prevents hemodynamic responses to endotoxinQ46045448
Nonlinear pharmacokinetics of recombinant human macrophage colony-stimulating factor (M-CSF) in rats.Q46060973
Expression and characterization of cysteine-modified variants of an amino-terminal fragment of bactericidal/permeability-increasing proteinQ46189668
Functional domains of recombinant bactericidal/permeability increasing protein (rBPI23).Q46200360
Drug Absorption and Metabolism Studies by Use of Portal Vein Infusion in the Rat. I. Pyloric Vein Cannulation and Its Application to Study of First-Pass Effect on Bioavailability of PropranololQ53925665
Normal hemodynamic parameters in conscious Wistar rats.Q54439670
Inhibition of endotoxin-induced cytokine release and neutrophil activation in humans by use of recombinant bactericidal/permeability-increasing protein.Q54609188
Prognostic Values of Tumor Necrosis Factor/Cachectin, Interleukin-l, Interferon- , and Interferon- in the Serum of Patients with Septic ShockQ64132947
Liver heparan sulfate structure. A novel molecular designQ64146700
Nonlinear pharmacokinetics of tissue-type plasminogen activator in three animal species and isolated perfused rat liverQ68359525
Heparin protects basic and acidic FGF from inactivationQ68895706
The fate of intravenously administered bFGF and the effect of heparinQ69447125
Clearance of human platelet factor 4 by liver and kidney: its alteration by heparinQ69633980
Pharmacokinetics of heparin and low molecular weight heparin fragment (Fragmin) in rabbits with impaired renal or metabolic clearanceQ69817892
Binding of platelet factor 4 to cultured human umbilical vein endothelial cellsQ71417814
Measurement of bactericidal/permeability-increasing protein in human body fluids by sandwich ELISAQ71609815
Role of kidney in the catabolic clearance of human platelet antiheparin proteins from rat circulationQ72624425
P433issue2
P304page(s)224-229
P577publication date1997-02-01
P1433published inPharmaceutical ResearchQ7180737
P1476titleThe role of liver and kidney on the pharmacokinetics of a recombinant amino terminal fragment of bactericidal/permeability-increasing protein in rats
P478volume14

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cites work (P2860)
Q27469619Large-plaque mutants of Sindbis virus show reduced binding to heparan sulfate, heightened viremia, and slower clearance from the circulation
Q35176262Receptors, mediators, and mechanisms involved in bacterial sepsis and septic shock

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