Novel inhibitors of bacterial cytokinesis identified by a cell-based antibiotic screening assay

scientific article published on 20 September 2005

Novel inhibitors of bacterial cytokinesis identified by a cell-based antibiotic screening assay is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M506741200
P698PubMed publication ID16174771

P50authorJeff ErringtonQ42414372
P2093author name stringIan Collins
Jörg Sievers
Michelle Hall
David R Brown
James M Bennett
Neil R Stokes
Valerie Rose
Stephanie Barker
Lloyd G Czaplewski
David Foulger
David J Haydon
Hazel Johnson
Helena B Thomaides
Rowena Halsey
Veronica M Errington
P2860cites workCrystal structure of the bacterial cell-division protein FtsZQ27748785
A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening AssaysQ28145712
Cytokinesis in bacteriaQ33186319
Combinatorial synthesis of substituted 3-(2-indolyl)piperidines and 2-phenyl indoles as inhibitors of ZipA-FtsZ interactionQ33206517
Inhibiting cell division in Escherichia coli has little if any effect on gene expression.Q34290607
Septation and chromosome segregation during sporulation in Bacillus subtilis.Q34455324
Structure, biochemistry and mechanism of action of glycopeptide antibioticsQ34665729
Probing the catalytic activity of a cell division-specific transpeptidase in vivo with beta-lactamsQ35098282
Salt stress is an environmental signal affecting degradative enzyme synthesis in Bacillus subtilisQ35584344
Temperature shift experiments with an ftsZ84(Ts) strain reveal rapid dynamics of FtsZ localization and indicate that the Z ring is required throughout septation and cannot reoccupy division sites once constriction has initiatedQ35625462
Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethalityQ37416206
EzrA prevents aberrant cell division by modulating assembly of the cytoskeletal protein FtsZQ41060828
2-Alkoxycarbonylaminopyridines: inhibitors of Mycobacterium tuberculosis FtsZ.Q44049255
Discovery of a small molecule that inhibits cell division by blocking FtsZ, a novel therapeutic target of antibioticsQ44571667
Structure-based design of carboxybiphenylindole inhibitors of the ZipA-FtsZ interactionQ44699497
A new 2-carbamoyl pteridine that inhibits mycobacterial FtsZ.Q44900678
Altered arrangement of proteins in the spore coat of a germination mutant of Bacillus subtilis.Q54496430
Dispersed mode of Staphylococcus aureus cell wall synthesis in the absence of the division machineryQ57990571
P433issue48
P407language of work or nameEnglishQ1860
P1104number of pages7
P304page(s)39709-39715
P577publication date2005-09-20
P1433published inJournal of Biological ChemistryQ867727
P1476titleNovel inhibitors of bacterial cytokinesis identified by a cell-based antibiotic screening assay
P478volume280

Reverse relations

cites work (P2860)
Q401834112,6-Difluorobenzamide Inhibitors of Bacterial Cell Division Protein FtsZ: Design, Synthesis, and Structure-Activity Relationships.
Q376272613-Phenyl substituted 6,7-dimethoxyisoquinoline derivatives as FtsZ-targeting antibacterial agents.
Q50474877A 4-aminofurazan derivative-A189-inhibits assembly of bacterial cell division protein FtsZ in vitro and in vivo.
Q33660699A Thiazole Orange Derivative Targeting the Bacterial Protein FtsZ Shows Potent Antibacterial Activity
Q37671492A bactericidal guanidinomethyl biaryl that alters the dynamics of bacterial FtsZ polymerization
Q40197475A benzamide-dependent ftsZ mutant reveals residues crucial for Z-ring assembly
Q37335812An FtsZ-targeting prodrug with oral antistaphylococcal efficacy in vivo
Q36505293An improved small-molecule inhibitor of FtsZ with superior in vitro potency, drug-like properties, and in vivo efficacy
Q27652237An inhibitor of FtsZ with potent and selective anti-staphylococcal activity
Q27330534Analysis of Antimicrobial-Triggered Membrane Depolarization Using Voltage Sensitive Dyes.
Q64068080Anti-infective Properties of the Golden Spice Curcumin
Q85707439Antimicrobial activity of a quinuclidine-based FtsZ inhibitor and its synergistic potential with β-lactam antibiotics
Q37894696Antimicrobials for bacterial bioterrorism agents
Q35741404BT-benzo-29 inhibits bacterial cell proliferation by perturbing FtsZ assembly
Q37579629Bacterial cell division: assembly, maintenance and disassembly of the Z ring
Q36650535Bacterial cell division: the mechanism and its precison
Q34691423Benzimidazole-based antibacterial agents against Francisella tularensis
Q37103616Cell-division inhibitors: new insights for future antibiotics
Q33741018Challenges of antibacterial discovery revisited
Q31089800Comparison of small molecule inhibitors of the bacterial cell division protein FtsZ and identification of a reliable cross-species inhibitor
Q40678741Creating an antibacterial with in vivo efficacy: synthesis and characterization of potent inhibitors of the bacterial cell division protein FtsZ with improved pharmaceutical properties
Q41265790Cytological Profile of Antibacterial FtsZ Inhibitors and Synthetic Peptide MciZ.
Q36597257Cytoskeletal cytoplasmic filament ribbon of Treponema: a member of an intermediate-like filament protein family
Q34576179Discovery of anti-TB agents that target the cell-division protein FtsZ.
Q34143487Drug discovery targeting cell division proteins, microtubules and FtsZ.
Q41003090Enterococcal and streptococcal resistance to PC190723 and related compounds: molecular insights from a FtsZ mutational analysis.
Q30497729FtsZ in bacterial cytokinesis: cytoskeleton and force generator all in one.
Q46040894Functional redundancy of division specific penicillin-binding proteins in Bacillus subtilis
Q38855290Identification of agents targeting FtsZ assembly
Q36076047In Vivo Pharmacodynamic Evaluation of an FtsZ Inhibitor, TXA-709, and Its Active Metabolite, TXA-707, in a Murine Neutropenic Thigh Infection Model.
Q92626551Indole-core-based novel antibacterial agent targeting FtsZ
Q53271602Multiple effects of benzamide antibiotics on FtsZ function.
Q33301984N-Benzyl-3-sulfonamidopyrrolidines as novel inhibitors of cell division in E. coli
Q65000980New application of tiplaxtinin as an effective FtsZ-targeting chemotype for an antimicrobial study.
Q37324603Novel approaches to discovery of antibacterial agents
Q33761632Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents
Q48032989Plumbagin inhibits cytokinesis in Bacillus subtilis by inhibiting FtsZ assembly--a mechanistic study of its antibacterial activity
Q28487890Protein interactions in genome maintenance as novel antibacterial targets
Q28538766Rational design of berberine-based FtsZ inhibitors with broad-spectrum antibacterial activity
Q28546375Screening for FtsZ Dimerization Inhibitors Using Fluorescence Cross-Correlation Spectroscopy and Surface Resonance Plasmon Analysis
Q28829559Streptomyces: a screening tool for bacterial cell division inhibitors
Q27682149Structural reorganization of the bacterial cell-division protein FtsZ from Staphylococcus aureus
Q34179164Structure-based design and screening of inhibitors for an essential bacterial GTPase, Der.
Q54272066Synthesis and antibacterial activity of novel 4-bromo-1H-indazole derivatives as FtsZ inhibitors.
Q35860159TXA709, an FtsZ-Targeting Benzamide Prodrug with Improved Pharmacokinetics and Enhanced In Vivo Efficacy against Methicillin-Resistant Staphylococcus aureus
Q37573808Targeting FtsZ for antibacterial therapy: a promising avenue
Q38013726The development of FtsZ inhibitors as potential antibacterial agents
Q46918546The interactions of cell division protein FtsZ with guanine nucleotides.
Q89535704The key bacterial cell division protein FtsZ as a novel antibacterial drug target
Q34459318The re-emergence of natural products for drug discovery in the genomics era.

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