Cucurbitacin B induces DNA damage and autophagy mediated by reactive oxygen species (ROS) in MCF-7 breast cancer cells

scientific article published on 28 May 2015

Cucurbitacin B induces DNA damage and autophagy mediated by reactive oxygen species (ROS) in MCF-7 breast cancer cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S11418-015-0918-4
P698PubMed publication ID26018422
P5875ResearchGate publication ID277410458

P50authorJinjian LuQ42709768
P2093author name stringXiuping Chen
Wenxue Li
Jiajie Guo
Guowen Ren
Tongye Sha
P2860cites workLC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processingQ24597817
Autophagy modulation as a potential therapeutic target for diverse diseasesQ27010076
The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancerQ28297155
Cucurbitacin B has a potent antiproliferative effect on breast cancer cells in vitro and in vivoQ39961315
A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation.Q43798608
Assays to assess autophagy induction and fusion of autophagic vacuoles with a degradative compartment, using monodansylcadaverine (MDC) and DQ-BSA.Q46129573
Cucurbitacin B induces DNA damage, G2/M phase arrest, and apoptosis mediated by reactive oxygen species (ROS) in leukemia K562 cellsQ46884660
Cucurbitacin B induces cell cycle arrest, apoptosis and autophagy associated with G actin reduction and persistent activation of cofilin in Jurkat cells.Q52626467
Oxidative stress and autophagy: the clash between damage and metabolic needsQ28387805
Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signalingQ28388989
Methods in mammalian autophagy researchQ29547276
The Beclin 1 network regulates autophagy and apoptosisQ29616539
Targeted constitutive activation of signal transducer and activator of transcription 3 in human hepatocellular carcinoma cells by cucurbitacin B.Q33339967
Autophagy and cancer therapyQ33584607
Cucurbitacin I induces protective autophagy in glioblastoma in vitro and in vivoQ33675791
Inhibition of Integrin-HER2 signaling by Cucurbitacin B leads to in vitro and in vivo breast tumor growth suppressionQ33688434
Cucurbitacin B, a novel in vivo potentiator of gemcitabine with low toxicity in the treatment of pancreatic cancerQ34112882
Biological activities and potential molecular targets of cucurbitacins: a focus on cancerQ34273013
DNA damage-induced activation of ATM and ATM-dependent signaling pathwaysQ34336538
Cucurbitacins and cucurbitane glycosides: structures and biological activitiesQ34433152
Cucurbitacin B inhibits human breast cancer cell proliferation through disruption of microtubule polymerization and nucleophosmin/B23 translocationQ34444520
Inhibitory effects of cucurbitacin B on laryngeal squamous cell carcinomaQ34588898
ROS, mitochondria and the regulation of autophagyQ34679713
Antiproliferative effects of cucurbitacin B in breast cancer cells: down-regulation of the c-Myc/hTERT/telomerase pathway and obstruction of the cell cycleQ35002186
Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62.Q35063122
Cucurbitacin B induced ATM-mediated DNA damage causes G2/M cell cycle arrest in a ROS-dependent mannerQ35088525
Inhibition of Wnt signaling by cucurbitacin B in breast cancer cells: reduction of Wnt-associated proteins and reduced translocation of galectin-3-mediated β-catenin to the nucleus.Q35631729
The triterpenoid cucurbitacin B augments the antiproliferative activity of chemotherapy in human breast cancerQ36763291
Synergistic effect of low-dose cucurbitacin B and low-dose methotrexate for treatment of human osteosarcomaQ37047540
Regulation of autophagy by reactive oxygen species (ROS): implications for cancer progression and treatmentQ37283952
gammaH2AX: a sensitive molecular marker of DNA damage and repairQ37687078
The DNA damage response and cancer therapyQ37977004
γH2AX as a novel endpoint to detect DNA damage: applications for the assessment of the in vitro genotoxicity of cigarette smokeQ38021898
DNA damage sensing by the ATM and ATR kinases.Q38134064
Therapeutic targeting of autophagy in cancer. Part II: pharmacological modulation of treatment-induced autophagyQ38220560
Cucurbitacin IIa induces caspase-3-dependent apoptosis and enhances autophagy in lipopolysaccharide-stimulated RAW 264.7 macrophages.Q39173587
Cucurbitacin B potently suppresses non-small-cell lung cancer growth: identification of intracellular thiols as critical targetsQ39206697
Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis.Q39375263
Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells.Q39530449
Cucurbitacin B, a small molecule inhibitor of the Stat3 signaling pathway, enhances the chemosensitivity of laryngeal squamous cell carcinoma cells to cisplatinQ39702599
Cucurbitacin B induces apoptosis and S phase cell cycle arrest in BEL-7402 human hepatocellular carcinoma cells and is effective via oral administrationQ39740110
Cucurbitacin B induces G2 arrest and apoptosis via a reactive oxygen species-dependent mechanism in human colon adenocarcinoma SW480 cellsQ39770785
Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cellsQ39824976
P433issue4
P921main subjectautophagyQ288322
reactive oxygen speciesQ424361
P304page(s)522-530
P577publication date2015-05-28
P1433published inJournal of Natural MedicinesQ20182030
P1476titleCucurbitacin B induces DNA damage and autophagy mediated by reactive oxygen species (ROS) in MCF-7 breast cancer cells
P478volume69

Reverse relations

cites work (P2860)
Q36634632A triterpenoid from wild bitter gourd inhibits breast cancer cells
Q38743353Carbazole alkaloids from Murraya koenigii trigger apoptosis and autophagic flux inhibition in human oral squamous cell carcinoma cells
Q48301430Cucurbitacin B Protects Against Pressure Overload Induced Cardiac Hypertrophy.
Q37701484Cucurbitacin B exerts anti-cancer activities in human multiple myeloma cells in vitro and in vivo by modulating multiple cellular pathways
Q87742397Cucurbitacin B suppresses metastasis mediated by reactive oxygen species (ROS) via focal adhesion kinase (FAK) in breast cancer MDA-MB-231 cells
Q40506281Identification and characterization of antibacterial compound(s) of cockroaches (Periplaneta americana).
Q38972954Inhibiting reactive oxygen species-dependent autophagy enhanced baicalein-induced apoptosis in oral squamous cell carcinoma
Q39410995Natural Compounds from Herbs that can Potentially Execute as Autophagy Inducers for Cancer Therapy.
Q39042339Natural products as modulator of autophagy with potential clinical prospects
Q26753053New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of Autophagy
Q48105319Oridonin induces apoptosis in human oral cancer cells via phosphorylation of histone H2AX.
Q37500854PTEN Activation by DNA Damage Induces Protective Autophagy in Response to Cucurbitacin B in Hepatocellular Carcinoma Cells.

Search more.