Randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma: an intergroup study of the European Organisation for Research and Treatment of Cancer Lung Cancer Group and the National Cancer Inst

scientific article

Randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma: an intergroup study of the European Organisation for Research and Treatment of Cancer Lung Cancer Group and the National Cancer Inst is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1200/JCO.20005.14.589
P698PubMed publication ID16192580

P50authorGiuseppe GiacconeQ37829946
Andrew BottomleyQ66812411
P2093author name stringMark Vincent
Jan P van Meerbeeck
Christian Manegold
Eric A Van Marck
Catherine Legrand
Channa Debruyne
National Cancer Institute of Canada
Rabab Gaafar
Rob J Van Klaveren
European Organisation for Research and Treatment of Cancer Lung Cancer Group
P433issue28
P407language of work or nameEnglishQ1860
P921main subjectlung cancerQ47912
patientQ181600
cisplatinQ412415
malignant pleural mesotheliomaQ18557602
P304page(s)6881-6889
P577publication date2005-10-01
P1433published inJournal of Clinical OncologyQ400292
P1476titleRandomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma: an intergroup study of the European Organisation for Research and Treatment of Cancer Lung Cancer Group and the National Cancer Inst
P478volume23

Reverse relations

cites work (P2860)
Q30474771A 26-year-old male with mesothelioma due to asbestos exposure
Q93369091A Novel Prospective Study Assessing the Combination of Photodynamic Therapy and Proton Radiation Therapy: Safety and Outcomes When Treating Malignant Pleural Mesothelioma
Q37296603A Phase II Study of Sorafenib in Malignant Mesothelioma: Results of Cancer and Leukemia Group B 30307
Q53003365A Significant Metabolic and Radiological Response after a Novel Targeted MicroRNA-based Treatment Approach in Malignant Pleural Mesothelioma.
Q38760623A catalogue of treatment and technologies for malignant pleural mesothelioma
Q40522944A phase 1b clinical trial of the CD40-activating antibody CP-870,893 in combination with cisplatin and pemetrexed in malignant pleural mesothelioma.
Q33414357A phase II trial of prolonged, continuous infusion of low-dose gemcitabine plus cisplatin in patients with advanced malignant pleural mesothelioma
Q33812537A pilot study of zoledronic acid in the treatment of patients with advanced malignant pleural mesothelioma
Q41846143A potential therapeutic strategy for malignant mesothelioma with gene medicine
Q35190713A randomised controlled trial of intravenous zoledronic acid in malignant pleural disease: a proof of principle pilot study
Q59132458A randomized phase II study of pleurectomy/decortication preceded or followed by (neo-)adjuvant chemotherapy in patients with early stage malignant pleural mesothelioma (EORTC 1205)
Q46115026Abundant expression of TIM-3, LAG-3, PD-1 and PD-L1 as immunotherapy checkpoint targets in effusions of mesothelioma patients
Q36948470Accuracy of pleural biopsy using thoracoscopy for the diagnosis of histologic subtype in patients with malignant pleural mesothelioma
Q36727434Active symptom control with or without chemotherapy in the treatment of patients with malignant pleural mesothelioma (MS01): a multicentre randomised trial
Q64889484Advances in pulmonary and pleural malignant disorders.
Q47912434Advances in systemic therapy for malignant mesothelioma: future perspectives
Q38153818Advances in the management of pleural disease.
Q37070229Advances in the systemic therapy of malignant pleural mesothelioma
Q38800916Advances in treatment of mesothelioma.
Q33813008An epigenetic mechanism for capecitabine resistance in mesothelioma
Q52659191An innovative mesothelioma treatment based on miR-16 mimic loaded EGFR targeted minicells (TargomiRs).
Q35182037Analysis of expression of programmed cell death 1 ligand 1 (PD-L1) in malignant pleural mesothelioma (MPM).
Q51757551Analysis of the effect of radiotherapy on malignant pleural mesothelioma when given on adjuvant or palliative basis
Q90056612Antiangiogeneic Strategies in Mesothelioma
Q33530405Antimetabolites and cancer: emerging data with a focus on antifolates
Q50864512Antimetabolites in the treatment of advanced pleural mesothelioma: a network meta-analysis of randomized clinical trials.
Q51428846Asbestos and the lung in the 21st century: an update.
Q28533736BAK and NOXA are critical determinants of mitochondrial apoptosis induced by bortezomib in mesothelioma
Q27851697BRCA1 is an essential mediator of vinorelbine-induced apoptosis in mesothelioma.
Q30478994BTS statement on malignant mesothelioma in the UK, 2007.
Q37335377Biomarkers for malignant pleural mesothelioma: current status
Q55053946Biomarkers in malignant mesothelioma-an unfulfilled need or a waste of resources?
Q52579899CONFIRM: a double-blind, placebo-controlled phase III clinical trial investigating the effect of nivolumab in patients with relapsed mesothelioma: study protocol for a randomised controlled trial.
Q88682206Cardiotoxicity of 5-fluorouracil and capecitabine in Chinese patients: a prospective study
Q38119922Challenges and controversies in the diagnosis of malignant mesothelioma: Part 2. Malignant mesothelioma subtypes, pleural synovial sarcoma, molecular and prognostic aspects of mesothelioma, BAP1, aquaporin-1 and microRNA.
Q64235291Characteristics and long-term outcomes of advanced pleural mesothelioma in Latin America (MeSO-CLICaP)
Q35141369Chemotherapy and targeted therapies for unresectable malignant mesothelioma
Q81295701Chemotherapy for malignant pleural mesothelioma
Q83789589Chemotherapy for malignant pleural mesothelioma
Q37090808Chemotherapy for malignant pleural mesothelioma: a review of current management and a look to the future
Q52672893Chemotherapy treatment in malignant pleural mesothelioma: a difficult history.
Q36755228Cisplatin and vinorelbine first-line chemotherapy in non-resectable malignant pleural mesothelioma
Q34957369Cisplatin in combination with Phenethyl Isothiocyanate (PEITC), a potential new therapeutic strategy for malignant pleural mesothelioma
Q50050310Clinical and biologic prognostic factors in malignant pleural mesothelioma
Q35542880Clinical characteristics and treatment outcomes in 132 patients with malignant mesothelioma
Q37679984Combinational therapy of crizotinib and afatinib for malignant pleural mesothelioma
Q59137556Combined modality treatment in mesothelioma: a systemic literature review with treatment recommendations
Q59132464Current chemotherapy strategies in malignant pleural mesothelioma
Q37086026Current concepts in malignant pleural mesothelioma.
Q28393560Current issues in malignant pleural mesothelioma evaluation and management
Q37232309Current therapies for malignant pleural mesothelioma
Q38059514Dendritic cell-based immunotherapy in mesothelioma
Q37612152Diagnostic values of soluble mesothelin-related peptides for malignant pleural mesothelioma: updated meta-analysis.
Q47974790Does selective pleural irradiation of malignant pleural mesothelioma allow radiation dose escalation? : A planning study
Q53214981Efficacy and safety of first- or second-line irinotecan, cisplatin, and mitomycin in mesothelioma.
Q90748160Emerging Treatments for Malignant Pleural Mesothelioma: Where Are We Heading?
Q36758593Emerging drugs for mesothelioma
Q48060347Estimation of an optimal chemotherapy utilization rate for malignant pleural mesothelioma: an evidence-based benchmark for cancer care
Q34035015Examining the relationships among health-related quality-of-life indicators in cancer patients participating in clinical trials: a pooled study of baseline EORTC QLQ-C30 data
Q39298123Expression of Wilms' tumor gene (WT1) is associated with survival in malignant pleural mesothelioma.
Q39933225Expression of the embryonic lethal abnormal vision-like protein HuR in human mesothelioma: association with cyclooxygenase-2 and prognosis
Q89017219FDG PET-derived parameters as prognostic tool in progressive malignant pleural mesothelioma treated patients
Q51617036FDG PET/CT patterns of treatment failure of malignant pleural mesothelioma: relationship to histologic type, treatment algorithm, and survival.
Q33639709First-in-human phase 1 of YS110, a monoclonal antibody directed against CD26 in advanced CD26-expressing cancers
Q35832320First-line chemotherapy with liposomal doxorubicin plus cisplatin for patients with advanced malignant pleural mesothelioma: phase II trial.
Q89598585Formulation of Folate-Modified Raltitrexed-Loaded Nanoparticles for Colorectal Cancer Theranostics
Q36354734From methotrexate to pemetrexed and beyond. A review of the pharmacodynamic and clinical properties of antifolates
Q37449036Future developments in the management of malignant pleural mesothelioma
Q37243005Gemcitabine and cisplatin in unresectable malignant mesothelioma of the pleura: a phase II study of the Southwest Oncology Group (SWOG 9810)
Q40176023Genomic profiling of malignant pleural mesothelioma with array-based comparative genomic hybridization shows frequent non-random chromosomal alteration regions including JUN amplification on 1p32.
Q28394028Guidelines for the diagnosis and treatment of malignant pleural mesothelioma
Q48394328Health-related quality of life and inflammatory markers in malignant pleural mesothelioma
Q37810109Health-related quality of life and symptom assessment in patients with myelodysplastic syndromes
Q37662700Histone deacetylase inhibitors in malignant pleural mesothelioma: preclinical rationale and clinical trials
Q36259724Human agonistic TRAIL receptor antibodies Mapatumumab and Lexatumumab induce apoptosis in malignant mesothelioma and act synergistically with cisplatin.
Q35642044Immune microenvironments in solid tumors: new targets for therapy
Q84596250Impact of tumor angiogenesis in peritoneal mesothelioma after radical cytoreduction and hyperthermic intraperitoneal chemotherapy
Q33877584Improved Outcomes with Modern Lung-Sparing Trimodality Therapy in Patients with Malignant Pleural Mesothelioma.
Q36322368Improved survival after introduction of chemotherapy for malignant pleural mesothelioma in Slovenia: Population-based survey of 444 patients
Q37880216Inactivation of Merlin in malignant mesothelioma cells and the Hippo signaling cascade dysregulation
Q39769492Incidence of interstitial lung disease in patients with mesothelioma in the west part of Japan
Q39818881Individualizing Mesothelioma Treatment: Small Steps Into a Brighter Future
Q39350596Induction chemotherapy vs post-operative adjuvant therapy for malignant pleural mesothelioma
Q34293068Investigational approaches for mesothelioma
Q91123540Ipilimumab and nivolumab in the treatment of recurrent malignant pleural mesothelioma (INITIATE): results of a prospective, single-arm, phase 2 trial
Q38633115Isolated thoracic perfusion with chemofiltration for progressive malignant pleural mesothelioma
Q28395597Latest developments in our understanding of the pathogenesis of mesothelioma and the design of targeted therapies
Q37666267Lung Cancer OncoGuia
Q31019143MDM2 and HIF1alpha expression levels in different histologic subtypes of malignant pleural mesothelioma: correlation with pathological and clinical data
Q34182679MET and PI3K/mTOR as a potential combinatorial therapeutic target in malignant pleural mesothelioma
Q39366003Malignant Mesothelioma: Time to Translate?
Q35623638Malignant Pleural Mesothelioma Outcomes in the Era of Combined Platinum and Folate Antimetabolite Chemotherapy.
Q21202901Malignant mesothelioma
Q47098675Malignant mesothelioma: Canadian perspective and research directions
Q33909330Malignant peritoneal mesothelioma: prognostic factors and oncologic outcome analysis
Q83412919Malignant pleural mesothelioma
Q59274199Malignant pleural mesothelioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Q34513958Malignant pleural mesothelioma: an update on diagnosis and treatment options
Q37217764Malignant pleural mesothelioma: current and future perspectives
Q37529848Malignant pleural mesothelioma: current treatments and emerging drugs.
Q26821919Malignant pleural mesothelioma: incidence, etiology, diagnosis, treatment, and occupational health
Q36728254Malignant pleural mesothelioma: update on treatment options with a focus on novel therapies.
Q37866786Malignant pleural mesothelioma: when is radiation therapy indicated?
Q37277434Management of malignant pleural mesothelioma-part 2: therapeutic approaches : Consensus of the Austrian Mesothelioma Interest Group (AMIG).
Q35834928Management of malignant pleural mesothelioma: a French multicenter retrospective study (GFPC 0802 study).
Q36830116Management options for malignant pleural mesothelioma: clinical and cost considerations
Q33705743Measuring symptoms as a critical component of drug development and evaluation in hematological diseases
Q38542421Medical and oncological management of malignant mesothelioma.
Q37866663Medical treatment of mesothelioma: anything new?
Q38476131Mesothelioma treatment
Q26800042Mesothelioma treatment: Are we on target? A review
Q58416980Metabolic vulnerability of cisplatin-resistant cancers
Q37956213Metastases to the oral region from pleural mesothelioma: Clinicopathologic review.
Q44669659Methodological issues in designing and reporting health-related quality of life in cancer clinical trials: the challenge of brain cancer studies
Q29248127Modern management of malignant pleural mesothelioma
Q36699347Molecular analysis of the effects of Piroxicam and Cisplatin on mesothelioma cells growth and viability
Q37232301Molecular biology of malignant mesothelioma
Q33372250Multicenter phase II trial of accelerated cisplatin and high-dose epirubicin followed by surgery or radiotherapy in patients with stage IIIa non-small-cell lung cancer with mediastinal lymph node involvement (N2-disease).
Q52581757New Perspectives on Diagnosis and Therapy of Malignant Pleural Mesothelioma.
Q87296127New directions in the second line treatment of non-small cell lung cancers and in the management of malignant pleural mesotheliomas
Q34101029New histone deacetylase inhibitors improve cisplatin antitumor properties against thoracic cancer cells.
Q26859274New insights into understanding the mechanisms, pathogenesis, and management of malignant mesotheliomas
Q36780582Newer issues in mesothelioma chemotherapy.
Q92134619Nintedanib in combination with pemetrexed and cisplatin for chemotherapy-naive patients with advanced malignant pleural mesothelioma (LUME-Meso): a double-blind, randomised, placebo-controlled phase 3 trial
Q99582736Nivolumab in pre-treated malignant pleural mesothelioma: real-world data from the Dutch expanded access program
Q39455555Novel insights into mesothelioma biology and implications for therapy.
Q33890499Novel systemic therapy against malignant pleural mesothelioma
Q52672324Novel therapies for malignant pleural mesothelioma.
Q38662242Optimal Therapy of Advanced Stage Mesothelioma
Q50484415Optimal gross tumor volume definition in lung-sparing intensity modulated radiotherapy for pleural mesothelioma: an in silico study.
Q36905239Optimising survival in malignant mesothelioma
Q34360248Overview of the biochemical and genetic processes in malignant mesothelioma.
Q37252398PI3 Kinase Pathway and MET Inhibition is Efficacious in Malignant Pleural Mesothelioma
Q38398970PTEN protein expression in malignant pleural mesothelioma
Q34516941Pemetrexed in thoracic cancer
Q33379936Pemetrexed plus carboplatin in elderly patients with malignant pleural mesothelioma: combined analysis of two phase II trials.
Q37081896Phase II study of pemetrexed and carboplatin plus bevacizumab as first-line therapy in malignant pleural mesothelioma
Q40166240Pleural Diseases: Saline Irrigation in Pleural Infection, Epidemiology of Pneumothorax, and Bevacizumab in Mesothelioma
Q28487719Preclinical demonstration of synergistic Active Nutrients/Drug (AND) combination as a potential treatment for malignant pleural mesothelioma
Q50049398Predictors of trimodality therapy and trends in therapy for malignant pleural mesothelioma
Q38961442Prognostic and predictive aspects of the tumor immune microenvironment and immune checkpoints in malignant pleural mesothelioma
Q43875251Prognostic nutritional index predicts outcomes of malignant pleural mesothelioma
Q53175010Prognostic value of 18F-FDG standard uptake value by integrated PET/CT in the staging of malignant pleural mesothelioma.
Q55318621Quantitative Clinical Staging for Patients With Malignant Pleural Mesothelioma.
Q37945636Raltitrexed in mesothelioma
Q64250473Raltitrexed increases radiation sensitivity of esophageal squamous carcinoma cells
Q36425940Ranpirnase--an antitumour ribonuclease: its potential role in malignant mesothelioma
Q34142500Ratio of intratumoral macrophage phenotypes is a prognostic factor in epithelioid malignant pleural mesothelioma
Q34402081Re-challenge with pemetrexed in advanced mesothelioma: a multi-institutional experience.
Q58128741Review of nintedanib plus pemetrexed/cisplatin in patients with malignant pleural mesothelioma: phase II results from the randomized, placebo-controlled LUME-Meso trial
Q38190418Role of microRNAs in malignant mesothelioma.
Q50665635Second-line gemcitabine-based chemotherapy regimens improve overall 3-year survival rate in patients with malignant pleural mesothelioma: a multicenter retrospective study.
Q26860736Serum mesothelin for diagnosing malignant pleural mesothelioma: an individual patient data meta-analysis
Q37582256Small bowel metastasis from pancreatic cancer in a long-term survival patient with synchronous advanced malignant pleural mesothelioma: A case report and literature review
Q54957187Soluble CD157 in pleural effusions: a complementary tool for the diagnosis of malignant mesothelioma.
Q37862752Soluble markers for diagnosis of malignant pleural mesothelioma
Q34096881Soluble mesothelin related peptides (SMRP) and osteopontin as protein biomarkers for malignant mesothelioma: analytical validation of ELISA based assays and characterization at mRNA and protein levels
Q44080402Stratification of malignant pleural mesothelioma prognosis using recursive partitioning analysis
Q36594263Surgical controversies in mesothelioma: MesoVATS addresses the role of surgical debulking
Q51716124Surgical resection of mesothelioma: an evidence-free practice.
Q38607308Survival in Good Performance Malignant Pleural Mesothelioma Patients; Prognostic Factors and Predictors of Response
Q41279899Synergistic targeting of malignant pleural mesothelioma cells by MDM2 inhibitors and TRAIL agonists
Q93380858Systemic Therapy Use and Outcomes After Relapse from Preoperative Radiation and Extrapleural Pneumonectomy for Malignant Pleural Mesothelioma
Q37992694Systemic treatment of malignant pleural mesothelioma
Q37260408Systemic treatments for mesothelioma: standard and novel
Q52672891Target therapy: new drugs or new combinations of drugs in malignant pleural mesothelioma.
Q55247848Targeting Tie-2/angiopoietin axis in experimental mesothelioma confers differential responses and raises predictive implications.
Q38704895Targeting YAP in malignant pleural mesothelioma.
Q47107902Targeting mesothelin receptors with drug-loaded bacterial nanocells suppresses human mesothelioma tumour growth in mouse xenograft models
Q43800002Thalidomide versus active supportive care for maintenance in patients with malignant mesothelioma after first-line chemotherapy (NVALT 5): an open-label, multicentre, randomised phase 3 study
Q47133389The "don't eat me" signal CD47 is a novel diagnostic biomarker and potential therapeutic target for diffuse malignant mesothelioma
Q89502927The Role of Neoadjuvant Chemotherapy in Patients with Resectable Malignant Pleural Mesothelioma - An Institutional and National Analysis
Q35686558The effectiveness and safety of platinum-based pemetrexed and platinum-based gemcitabine treatment in patients with malignant pleural mesothelioma
Q38148036The function, mechanisms, and role of the genes PTEN and TP53 and the effects of asbestos in the development of malignant mesothelioma: a review focused on the genes' molecular mechanisms
Q35200628The role of interleukin-6 in malignant mesothelioma
Q59132459The use of patient-reported outcome measures (PROMs) in the management of malignant pleural mesothelioma: a descriptive literature survey
Q36980982Thresholds for clinical importance for four key domains of the EORTC QLQ-C30: physical functioning, emotional functioning, fatigue and pain
Q37745215Tissue transglutaminase (TG2) enables survival of human malignant pleural mesothelioma cells in hypoxia.
Q37806309Translational advances in pleural malignancies
Q37734455Translational therapies for malignant pleural mesothelioma.
Q61583558Treatment for non small cell lung cancer, small cell lung cancer and pleural mesothelioma within the EORTC Lung Cancer Group: past, present and future
Q38631254Tremelimumab for the treatment of malignant mesothelioma
Q90808642Tumour Treating Fields in combination with pemetrexed and cisplatin or carboplatin as first-line treatment for unresectable malignant pleural mesothelioma (STELLAR): a multicentre, single-arm phase 2 trial
Q50612432Unusual Contiguous Soft Tissue Spread of Advanced Malignant Mesothelioma Detected by FDG PET/CT.
Q45226201Use of cancer therapy at the end of life in patients with malignant pleural mesothelioma.
Q38602994Use of the lung cancer-specific Quality of Life Questionnaire EORTC QLQ-LC13 in clinical trials: A systematic review of the literature 20 years after its development
Q38758684Validation of Progression-Free Survival as a Surrogate Endpoint for Overall Survival in Malignant Mesothelioma: Analysis of Cancer and Leukemia Group B and North Central Cancer Treatment Group (Alliance) Trials
Q36946792Whole exome and targeted deep sequencing identify genome-wide allelic loss and frequent SETDB1 mutations in malignant pleural mesotheliomas.
Q39947427YAP1 is involved in mesothelioma development and negatively regulated by Merlin through phosphorylation
Q84192226[Cytoreductive surgery and hyperthermic intrathoracic chemotherapy perfusion]
Q82061962[Guidelines of the European Respiratory Society and the European Society of Thoracic Surgeons for the management of malignant pleural mesothelioma]
Q80426618[Malignant pleural mesothelioma: interrogations and hopes concerning the expected epidemic]
Q81415520[Role of DNA microarrays in the diagnosis of pleural exudates: a feasibility study]

Search more.