Too much of a good thing: why it is bad to stimulate the beta cell to secrete insulin

scientific article published on 2 February 2008

Too much of a good thing: why it is bad to stimulate the beta cell to secrete insulin is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00125-008-0930-2
P698PubMed publication ID18246324
P5875ResearchGate publication ID5606525

P50authorKathryn Aston-MourneyQ59601236
P2093author name stringG Morahan
S Andrikopoulos
J Proietto
P2860cites workPancreatic beta-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPKQ55847305
Beta-cell dysfunction in nondiabetic HLA identical siblings of insulin-dependent diabeticsQ71470121
Diazoxide causes recovery of beta-cell glucose responsiveness in 90% pancreatectomized diabetic ratsQ72723734
Association of a variant in exon 31 of the sulfonylurea receptor 1 (SUR1) gene with type 2 diabetes mellitus in French CaucasiansQ73074696
K(ATP) channel openers protect rat islets against the toxic effect of streptozotocinQ74052004
Metabolic diapause in pancreatic beta-cells expressing a gain-of-function mutant of the forkhead protein Foxo1Q79362559
Role of insulin resistance in predicting progression to type 1 diabetesQ80400738
Evidence for a role of superoxide generation in glucose-induced beta-cell dysfunction in vivoQ80756060
Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivoQ80838553
EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndromeQ28142981
Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A geneQ28469173
Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survivalQ28593963
Hydroperoxide metabolism in mammalian organsQ29614205
Glycemic durability of rosiglitazone, metformin, or glyburide monotherapyQ29620534
Insulin resistance and antidiabetic drugsQ33760266
Differential effect of inbred mouse strain (C57BL/6, DBA/2, 129T2) on insulin secretory function in response to a high fat dietQ34458277
Islet beta cell failure in type 2 diabetesQ34698810
Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cellsQ34724292
How mitochondrial damage affects cell functionQ34953719
Endoplasmic reticulum stress and diabetes mellitus.Q35065115
A new pharmacology--drugging stressed folding pathways.Q36187852
Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similaritiesQ36321572
Endoplasmic reticulum stress signaling in diseaseQ36610455
Insulin resistance and hypersecretion in obesity. European Group for the Study of Insulin Resistance (EGIR).Q37371843
Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cellsQ38303252
Improvement in insulin secretion in diabetes after diazoxideQ39368203
High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetesQ40137823
Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetesQ40176269
Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stressQ40527936
The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP1 in Ins2+/Akita pancreatic beta cells.Q40581298
A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia.Q40734688
Overnight inhibition of insulin secretion restores pulsatility and proinsulin/insulin ratio in type 2 diabetes.Q41756772
Glucose homeostasis in the nonobese diabetic mouse at the prediabetic stageQ42451830
High glucose-induced impairment in insulin secretion is associated with reduction in islet glucokinase in a mouse model of susceptibility to islet dysfunctionQ42482387
The second activating glucokinase mutation (A456V): implications for glucose homeostasis and diabetes therapyQ43935515
Comparison of insulin secretory function in two mouse models with different susceptibility to beta-cell failureQ44000598
A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1.Q44297979
Coupling of beta-cell desensitization by hyperglycemia to excessive stimulation and circulating insulin in glucose-infused ratsQ44443777
Insulin resistance is a risk factor for progression to type 1 diabetesQ45103752
Sulfonylurea induced beta-cell apoptosis in cultured human isletsQ45105959
A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J miceQ45281560
Functional and molecular defects of pancreatic islets in human type 2 diabetesQ45285356
Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosisQ46744627
Increased nicotinamide nucleotide transhydrogenase levels predispose to insulin hypersecretion in a mouse strain susceptible to diabetes.Q46961703
Variant in sulfonylurea receptor-1 gene is associated with high insulin concentrations in non-diabetic Mexican Americans: SUR-1 gene variant and hyperinsulinemia.Q51567104
Early changes in postprandial insulin secretion, not in insulin sensitivity, characterize juvenile obesity.Q51595447
Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues.Q53787751
The influence of genetic background on the expression of mutations at the diabetes locus in the mouse. III. Effect of H-2 haplotype and sex.Q54527758
The influence of genetic background on the induction of oxidative stress and impaired insulin secretion in mouse islets.Q54611520
Familial hyperinsulinism caused by an activating glucokinase mutationQ55670538
P433issue4
P921main subjectpreproinsulinQ7240673
P304page(s)540-545
P577publication date2008-02-02
P1433published inDiabetologiaQ5270140
P1476titleToo much of a good thing: why it is bad to stimulate the beta cell to secrete insulin
P478volume51

Reverse relations

cites work (P2860)
Q27310129A low-carbohydrate high-fat diet increases weight gain and does not improve glucose tolerance, insulin secretion or β-cell mass in NZO mice
Q47374720A novel oral form of salmon calcitonin improves glucose homeostasis and reduces body weight in diet-induced obese rats
Q47096488Antidiabetic drug glyburide modulates depressive-like behavior comorbid with insulin resistance
Q34008552Association of diabetes duration and diabetes treatment with the risk of hepatocellular carcinoma
Q37668822Bisphenol A Is More Potent than Phthalate Metabolites in Reducing Pancreatic β-Cell Function
Q48146168Diabetes Mellitus and Risk of Hepatocellular Carcinoma.
Q42996831Do insulinotropic glucose-lowering drugs do more harm than good? The hypersecretion hypothesis revisited
Q36279518Dopamine-mediated autocrine inhibitory circuit regulating human insulin secretion in vitro
Q37199572Effects of dietary fat subtypes on glucose homeostasis during pregnancy in rats
Q44186891Elevated levels of branched-chain amino acids have little effect on pancreatic islet cells, but L-arginine impairs function through activation of the endoplasmic reticulum stress response
Q38056123Endoplasmic reticulum stress in diabetes: New insights of clinical relevance
Q37163504GPR40: good cop, bad cop?
Q42459504Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia
Q38744831Improving glycaemic control in type 2 diabetes: Stimulate insulin secretion or provide beta-cell rest?
Q81157739Insulin may have a role to play in protecting beta cells from deterioration in diabetes
Q33930824Lipid receptors and islet function: therapeutic implications?
Q77792823Maternal urinary phthalate metabolites in relation to gestational diabetes and glucose intolerance during pregnancy
Q24653018Molecular physiology of mammalian glucokinase
Q42177561Multimodal imaging of pancreatic beta cells in vivo by targeting transmembrane protein 27 (TMEM27).
Q36867430Pioglitazone acutely reduces energy metabolism and insulin secretion in rats
Q24642826Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrations
Q24314902Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis
Q57496161Visualization of methylglyoxal in living cells and diabetic mice model with a 1,8-naphthalimide-based two-photon fluorescent probe

Search more.