Self-hydroxylation of taurine/alpha-ketoglutarate dioxygenase: evidence for more than one oxygen activation mechanism

scientific article published in December 2005

Self-hydroxylation of taurine/alpha-ketoglutarate dioxygenase: evidence for more than one oxygen activation mechanism is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00775-005-0059-4
P698PubMed publication ID16320009

P50authorRobert HausingerQ29887929
P2093author name stringLawrence Que
Matthew J Ryle
Sudha Marimanikkuppam
Kevin D Koehntop
P2860cites workHIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensingQ24291102
Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathwayQ24539006
Identification of sulfate starvation-regulated genes in Escherichia coli: a gene cluster involved in the utilization of taurine as a sulfur sourceQ24682038
Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthaseQ27621182
Structure of proline 3-hydroxylase. Evolution of the family of 2-oxoglutarate dependent oxygenasesQ27636647
X-ray crystal structure of Escherichia coli taurine/alpha-ketoglutarate dioxygenase complexed to ferrous iron and substratesQ27638860
Autocatalytic generation of dopa in the engineered protein R2 F208Y from Escherichia coli ribonucleotide reductase and crystal structure of the dopa-208 proteinQ27732006
Crystal structures of two self-hydroxylating ribonucleotide reductase protein R2 mutants: structural basis for the oxygen-insertion step of hydroxylation reactions catalyzed by diiron proteinsQ27764908
Structure of a cephalosporin synthaseQ27765198
Crystal structure of tyrosine hydroxylase with bound cofactor analogue and iron at 2.3 A resolution: self-hydroxylation of Phe300 and the pterin-binding siteQ27765365
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylationQ27860876
Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damageQ28201532
Characterization of alpha-ketoglutarate-dependent taurine dioxygenase from Escherichia coliQ28248291
Metal-catalyzed oxidation and mutagenesis studies on the iron(II) binding site of 1-aminocyclopropane-1-carboxylate oxidaseQ28256458
FeII/alpha-ketoglutarate-dependent hydroxylases and related enzymesQ28259624
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNAQ29618091
Characterization and cDNA cloning of an immune-induced lysozyme from cultured Aedes albopictus mosquito cellsQ30873959
A new tyrosyl radical on Phe208 as ligand to the diiron center in Escherichia coli ribonucleotide reductase, mutant R2-Y122H. Combined x-ray diffraction and EPR/ENDOR studiesQ31139122
The 2-His-1-carboxylate facial triad: a versatile platform for dioxygen activation by mononuclear non-heme iron(II) enzymes.Q33212392
Aromatic hydrocarbon dioxygenases in environmental biotechnologyQ33941468
Oxygenase activity in the self-hydroxylation of (s)-2-hydroxypropylphosphonic acid epoxidase involved in fosfomycin biosynthesisQ34341658
Geometric and electronic structure/function correlations in non-heme iron enzymesQ34647398
Blue color, metal content, and substrate binding in 4-hydroxyphenylpyruvate dioxygenase from Pseudomonas sp. strain P. J. 874.Q34715403
Interconversion of two oxidized forms of taurine/alpha-ketoglutarate dioxygenase, a non-heme iron hydroxylase: evidence for bicarbonate bindingQ34916802
Dioxygen activation at mononuclear nonheme iron active sites: enzymes, models, and intermediatesQ35660894
Laser-excited Raman spectroscopy of biomolecules. I. Native lysozyme and its constituent amino acidsQ36559153
Site-directed mutagenesis of the active site serine290 in flavanone 3beta-hydroxylase from Petunia hybridaQ38315986
Electronic and resonance Raman spectra of iron(III) complexes of enterobactin, catechol, and N-methyl-2,3-dihydroxybenzamideQ39863229
The 2-His-1-carboxylate facial triad--an emerging structural motif in mononuclear non-heme iron(II) enzymesQ41699906
Purification and characterization of 2,4-dichlorophenoxyacetate/alpha-ketoglutarate dioxygenase.Q42286412
Purification and characterization of the blue-green rat phaeochromocytoma (PC12) tyrosine hydroxylase with a dopamine-Fe(III) complex. Reversal of the endogenous feedback inhibition by phosphorylation of serine-40Q42797292
Resonance Raman studies of the iron(II)--alpha-keto acid chromophore in model and enzyme complexesQ43678116
Alternative reactivity of an alpha-ketoglutarate-dependent iron(II) oxygenase: enzyme self-hydroxylationQ43678151
Rational reprogramming of the R2 subunit of Escherichia coli ribonucleotide reductase into a self-hydroxylating monooxygenase.Q43679732
O2- and alpha-ketoglutarate-dependent tyrosyl radical formation in TauD, an alpha-keto acid-dependent non-heme iron dioxygenaseQ44318465
Posttranslational Hydroxylation of Human Phenylalanine Hydroxylase Is a Novel Example of Enzyme Self-Repair within the Second Coordination Sphere of Catalytic IronQ44386085
The first direct characterization of a high-valent iron intermediate in the reaction of an alpha-ketoglutarate-dependent dioxygenase: a high-spin FeIV complex in taurine/alpha-ketoglutarate dioxygenase (TauD) from Escherichia coliQ44479690
Evidence for hydrogen abstraction from C1 of taurine by the high-spin Fe(IV) intermediate detected during oxygen activation by taurine:alpha-ketoglutarate dioxygenase (TauD).Q44626294
Aberrant activity of the DNA repair enzyme AlkB.Q44889676
Succinate complex crystal structures of the alpha-ketoglutarate-dependent dioxygenase AtsK: steric aspects of enzyme self-hydroxylationQ45149900
Steady-state and transient kinetic analyses of taurine/alpha-ketoglutarate dioxygenase: effects of oxygen concentration, alternative sulfonates, and active-site variants on the FeIV-oxo intermediateQ45307717
Kinetic dissection of the catalytic mechanism of taurine:alpha-ketoglutarate dioxygenase (TauD) from Escherichia coliQ46517404
EXAFS spectroscopic evidence for an Fe=O unit in the Fe(IV) intermediate observed during oxygen activation by taurine:alpha-ketoglutarate dioxygenaseQ47270304
Identification of an Fe(III)-dihydroxyphenylalanine site in recombinant phosphomannose isomerase from Candida albicans.Q50530232
Resonance Raman studies on the blue-green-colored bovine adrenal tyrosine 3-monooxygenase (tyrosine hydroxylase). Evidence that the feedback inhibitors adrenaline and noradrenaline are coordinated to iron.Q50892785
4-Hydroxyphenylpyruvate dioxygenase is an iron-tyrosinate protein.Q50907639
Mechanism of assembly of the tyrosyl radical-dinuclear iron cluster cofactor of ribonucleotide reductase.Q54694230
Direct detection of oxygen intermediates in the non-heme Fe enzyme taurine/alpha-ketoglutarate dioxygenase.Q55038031
Stopped-Flow Kinetic Analysis ofEscherichia coliTaurine/α-Ketoglutarate Dioxygenase: Interactions with α-Ketoglutarate, Taurine, and Oxygen†Q57831112
Resonance Raman Studies of Catecholate and Phenolate Complexes of Recombinant Human Tyrosine HydroxylaseQ58110894
Residues Important for Radical Stability in Ribonucleotide Reductase fromEscherichia coliQ60643019
Electron Injection through a Specific Pathway Determines the Outcome of Oxygen Activation at the Diiron Cluster in the F208Y Mutant ofEscherichia coliRibonucleotide Reductase Protein R2†Q60653659
Engineering of the iron site in ribonucleotide reductase to a self-hydroxylating monooxygenaseQ68111892
The mechanism of alpha-ketoisocaproate oxygenase. Formation of beta-hydroxyisovalerate from alpha-ketoisocaproateQ70373409
Dioxygen is the source of the mu-oxo bridge in iron ribonucleotide reductaseQ72272444
One motif--many different reactionsQ73505100
Phenylalanine residues in the active site of tyrosine hydroxylase: mutagenesis of Phe300 and Phe309 to alanine and metal ion-catalyzed hydroxylation of Phe300Q78166165
P433issue1
P304page(s)63-72
P577publication date2005-12-01
P1433published inJournal of Biological Inorganic ChemistryQ3186899
P1476titleSelf-hydroxylation of taurine/alpha-ketoglutarate dioxygenase: evidence for more than one oxygen activation mechanism
P478volume11