Properties of a selective kappa agonist, U-50,488H

scientific article published on November 15, 1982

Properties of a selective kappa agonist, U-50,488H is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/0024-3205(82)90132-1
P953full work available online athttps://api.elsevier.com/content/article/PII:0024320582901321?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:0024320582901321?httpAccept=text/xml
P698PubMed publication ID6131357

P2093author name stringR. A. Lahti
P. F. VonVoigtlander
VonVoigtlander PF
C. Barsuhn
P2860cites workJournal of Pharmacology and Experimental TherapeuticsQ1500272
Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reactionQ27860958
Chronic naloxone results in prolonged increases in opiate binding sites in brainQ40177996
3H-ethylketocyclazocine binding: Lack of evidence for a separate κ receptor in rats CNSQ40285609
Dynorphin Is a Specific Endogenous Ligand of the κ Opioid ReceptorQ44352111
Bremazocine: A potent, long-acting opiate kappa-agonistQ46629270
High affinity binding of [3H]ethylketocyclazocine to rat brain homogenateQ72148483
P433issue20-21
P407language of work or nameEnglishQ1860
P1104number of pages4
P304page(s)2257-2260
P577publication date1982-11-01
1982-11-15
P1433published inLife SciencesQ5256275
P1476titleProperties of a selective kappa agonist, U-50,488H
P478volume31

Reverse relations

cites work (P2860)
Q33869693A cell-based, high-throughput homogeneous time-resolved fluorescence assay for the screening of potential κ-opioid receptor agonists
Q68258330A kappa opiate agonist, U50, 488H, enhances energy expenditure in rats
Q44338592Activation of kappa opioid receptors decreases synaptic transmission and inhibits long-term potentiation in the basolateral amygdala of the mouse
Q44349908Activity of the δ-Opioid Receptor Is Partially Reduced, Whereas Activity of the κ-Receptor Is Maintained in Mice Lacking the μ-Receptor
Q44352546Affinities of some common opioid analgesics towards four binding sites in mouse brain
Q71852415Anti-inflammatory effects of kappa-opioids in adjuvant arthritis
Q44350679Behavioral effects of a novel kappa opioid analgesic, U-50488, in rats and rhesus monkeys
Q35754811Bremazocine differentially antagonizes responses to selective mu and delta opioid receptor agonists in rat hippocampus
Q42028208Cardiovascular actions of the κ‐agonist, U‐50,488H, in the absence and presence of opioid receptor blockade
Q44352684Characterization of kappa1-opioid receptor binding in human insular cortex
Q35237319Chemical structures and biological activities of non-peptide selective kappa opioid ligands
Q44351416Delta and mu opioid receptors from the brain of a urodele amphibian, the rough-skinned newt Taricha granulosa: cloning, heterologous expression, and pharmacological characterization
Q44347810Design and synthesis of KNT-127, a δ-opioid receptor agonist effective by systemic administration
Q41864970Different profile of electrocortical power spectrum changes after micro-infusion into the locus coeruleus of selective agonists at various opioid receptor subtypes in rats
Q28379331Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50,488H and attenuates morphine withdrawal
Q43978577Dynorphin A decreases voltage-dependent calcium conductance of mouse dorsal root ganglion neurones
Q44335235Dynorphin A-( 1-13)-Tyr14Leu15-Phe16-Asn17-Gly18-Pro19: a potent and selective κ opioid peptide
Q42715007Effect of opioid receptor subtype-selective agonists on purinergic and adrenergic components of neurogenic contractions of mouse vas deferens
Q73865949Endogenous opiates in the chick retina and their role in form-deprivation myopia
Q44343222Enhancement of blood-brain barrier permeability to sodium fluorescein by stimulation of mu opioid receptors in mice
Q44336555Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 3: Synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies
Q43774611Evaluation of the effects of opioid agonists and antagonists under a delayed matching-to-sample procedure in pigeons
Q37227174Evaluation of the effects of specific opioid receptor agonists in a rodent model of spinal cord injury
Q34496610Gonadal hormone modulation of mu, kappa, and delta opioid antinociception in male and female rats
Q44332663In vivo modulation of post-spike excitability in vasopressin cells by kappa-opioid receptor activation
Q43640234Inducible HSP70 mediates delayed cardioprotection via U-50488H pretreatment in rat ventricular myocytes
Q69350003Inhibitory effect of a selective kappa receptor agonist, U-50, 488H, on methamphetamine-elicited ipsilateral circling behavior in rats with unilateral nigral lesions
Q48623087Intrathecal administration of dynorphin A and its fragments increase heart rate and arterial pressure in the urethane anesthetized rat: mediation by a nonopioid mechanism
Q44340949Involvement of kappa-opioid receptors in peripheral response to nerve stimulation in kappa-opioid receptor knockout mice
Q38312641Kappa Opioid Receptor Agonist and Brain Ischemia
Q44352932Kappa-opioid receptor activation inhibits post-spike depolarizing after-potentials in rat supraoptic nucleus neurones in vitro
Q43869162Long-acting fentanyl analogues: synthesis and pharmacology of N-(1-phenylpyrazolyl)-N-(1-phenylalkyl-4-piperidyl)propanamides.
Q44345751Modulation of feline bladder and distal urethral responses to dorsal sacral root stimulation by intrathecal administration of a kappa 1-opioid agonist
Q35027469Neuroregulation of mucus secretion by opioid receptors and KATP and BKCa channels in ferret trachea in vitro
Q47838207Neurotransmitter-mediated changes in the electrophysiological properties of pituicytes
Q37660087New therapeutic potential for psychoactive natural products
Q44351684Opioid receptor subtypes involved in the central inhibition of urinary bladder motility
Q40139515Opioid regulation of CNS dopaminergic pathways: A review of methodology, receptor types, regional variations and species differences
Q83285774Pharmacology of a new tritiated endomorphin-2 analog containing the proline mimetic cis-2-aminocyclohexanecarboxylic acid
Q28138587Potent antinociceptive effects of TRK-820, a novel kappa-opioid receptor agonist
Q42054397Protection by U-50,488H against β-chlornaltrexamine antagonism of nitrous oxide antinociception in mice
Q39468417Receptors in the dorsal horn and intrathecal drug administration
Q69022182Release of substance P from the cat spinal cord
Q44334609Renal responses to the kappa-opioid-receptor agonist U-50488H in conscious lambs
Q43263805Role of protein kinase C-epsilon in the development of kappa-opioid receptor tolerance to U50,488H in rat ventricular myocytes
Q41527783Sensitization to the Behavioral Effects of Cocaine: Modulation by Dynorphin and κ-Opioid Receptor Agonists
Q43647880Sex differences in opioid antinociception: kappa and 'mixed action' agonists
Q48190709Striatal neurochemistry of dynorphin-(1-13): in vivo electrochemical semidifferential analyses
Q43070634Structure-activity relationship studies of dynorphin A and related peptides
Q44336656Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 3, novel propellane derivatives with pentacyclic skeletons
Q44333623Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology. Part 2: Propellane derivatives with an amide side chain
Q39422689Synthesis of quinolinomorphinan-4-ol derivatives as δ opioid receptor agonists
Q34578586The diverse molecular mechanisms responsible for the actions of opioids on the cardiovascular system
Q54597380The effect of U-50,488H, A κ-opiate receptor agonist on tolerance to the analgesic and hyperthermic effects of morphine in the rat
Q68936189The histamine-releasing effect of dynorphin and other peptides possessing Arg-Pro sequences
Q44352442The opioid κ-selective compound U−50,488H does not inhibit intestinal propulsion in rats
Q33890721The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse
Q34132638The role of κ-opioid receptor activation in mediating antinociception and addiction
Q31965867The selective kappa-opioid receptor agonist U50,488H attenuates voluntary ethanol intake in the rat.
Q56566621U-50,488 and the к receptor: A personalized account covering the period 1973 to 1990
Q44333654Ventral tegmental injections of a selective μ or δ opioid enhance feeding in food-deprived rats
Q44350434κ-Opioid Regulation of Neuronal Activity in the Rat Supraoptic NucleusIn Vivo

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