Replacement of histidine in position 105 in the α₅ subunit by cysteine stimulates zolpidem sensitivity of α₅β₂γ₂ GABA(A) receptors

scientific article published in December 2007

Replacement of histidine in position 105 in the α₅ subunit by cysteine stimulates zolpidem sensitivity of α₅β₂γ₂ GABA(A) receptors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1471-4159.2007.04982.X
P698PubMed publication ID17953656
P5875ResearchGate publication ID5891391

P2093author name stringErwin Sigel
Roland Baur
P2860cites workRole of the histidine residue at position 105 in the human alpha 5 containing GABA(A) receptor on the affinity and efficacy of benzodiazepine site ligandsQ28344902
Identification of amino acid residues responsible for the alpha5 subunit binding selectivity of L-655,708, a benzodiazepine binding site ligand at the GABA(A) receptorQ33942239
Mapping of the benzodiazepine recognition site on GABA(A) receptorsQ33960772
Subunit composition, distribution and function of GABA(A) receptor subtypesQ34143787
Comparative modeling of GABA(A) receptors: limits, insights, future developments.Q35165207
A point mutation in the gamma2 subunit of gamma-aminobutyric acid type A receptors results in altered benzodiazepine binding site specificityQ36562133
Pharmacology of recombinant gamma-aminobutyric acidA receptors rendered diazepam-insensitive by point-mutated alpha-subunits.Q38334136
On the Benzodiazepine Binding Pocket in GABAA ReceptorsQ40617515
The relative amount of cRNA coding for gamma2 subunits affects stimulation by benzodiazepines in GABA(A) receptors expressed in Xenopus oocytesQ40699569
From ion currents to genomic analysis: recent advances in GABAA receptor research.Q40956408
Subtle changes in residue 77 of the gamma subunit of alpha1beta2gamma2 GABAA receptors drastically alter the affinity for ligands of the benzodiazepine binding siteQ41111015
The benzodiazepine binding site of GABAA receptorsQ41679474
Comparison of the effects of zaleplon, zolpidem, and triazolam at various GABA(A) receptor subtypesQ44136555
Properties of single sodium channels translated by Xenopus oocytes after injection with messenger ribonucleic acidQ44719504
Conformational changes at benzodiazepine binding sites of GABA(A) receptors detected with a novel techniqueQ45247881
The effect of subunit composition of rat brain GABAA receptors on channel functionQ48875490
Key amino acids in the gamma subunit of the gamma-aminobutyric acidA receptor that determine ligand binding and modulation at the benzodiazepine siteQ48950667
The major site of photoaffinity labeling of the gamma-aminobutyric acid type A receptor by [3H]flunitrazepam is histidine 102 of the alpha subunit.Q53725650
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)2556-2564
P577publication date2007-12-01
P1433published inJournal of NeurochemistryQ6295643
P1476titleReplacement of histidine in position 105 in the α₅ subunit by cysteine stimulates zolpidem sensitivity of α₅β₂γ₂ GABA(A) receptors
P478volume103

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cites work (P2860)
Q24628464A venom-derived neurotoxin, CsTx-1, from the spider Cupiennius salei exhibits cytolytic activities
Q42701697Functional characterization of GABAA receptor-mediated modulation of cortical neuron network activity in microelectrode array recordings
Q56603639Structure of a human synaptic GABAA receptor
Q33677681TbIRK is a signature sequence free potassium channel from Trypanosoma brucei locating to acidocalcisomes.
Q36176472The cannabinoid CB1 receptor antagonists rimonabant (SR141716) and AM251 directly potentiate GABA(A) receptors
Q61449922Zolpidem Activation of Alpha 1-Containing GABA Receptors Selectively Inhibits High Frequency Action Potential Firing of Cortical Neurons
Q37040099Zolpidem is a potent stoichiometry-selective modulator of α1β3 GABAA receptors: evidence of a novel benzodiazepine site in the α1-α1 interface
Q34945410acr-23 Encodes a monepantel-sensitive channel in Caenorhabditis elegans
Q35921715myo-Inositol uptake is essential for bulk inositol phospholipid but not glycosylphosphatidylinositol synthesis in Trypanosoma brucei

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