LKB1 and the regulation of malonyl-CoA and fatty acid oxidation in muscle

scientific article published on 9 October 2007

LKB1 and the regulation of malonyl-CoA and fatty acid oxidation in muscle is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPENDO.00371.2007
P8608Fatcat IDrelease_mh2gtav7tjeqxjccmtyovdolmu
P698PubMed publication ID17925454
P5875ResearchGate publication ID5920499

P2093author name stringKim HJ
Brown JD
Winder WW
Thomson DM
Barrow JR
Condon BM
Fillmore N
P2860cites workComplexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascadeQ21245891
AMP-Activated Protein Kinase in Metabolic Control and Insulin SignalingQ22241925
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1Q24310603
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stressQ24633606
Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3Q24672153
Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinasesQ27939305
LKB1 is the upstream kinase in the AMP-activated protein kinase cascadeQ28610414
Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exerciseQ28610612
The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysisQ29618429
Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contractionQ33841869
Long-chain acyl-CoA esters inhibit phosphorylation of AMP-activated protein kinase at threonine-172 by LKB1/STRAD/MO25.Q34383662
Electrical stimulation inactivates muscle acetyl-CoA carboxylase and increases AMP-activated protein kinaseQ34423699
AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARalpha and PGC-1.Q34477777
LKB1-dependent signaling pathwaysQ34535140
Skeletal muscle and heart LKB1 deficiency causes decreased voluntary running and reduced muscle mitochondrial marker enzyme expression in miceQ34559719
Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1.Q36248613
Physiological role of ROCKs in the cardiovascular systemQ36392528
Role of AMP-activated protein kinase in the molecular adaptation to endurance exercise.Q36649618
Cloning of human acetyl-CoA carboxylase-beta and its unique featuresQ37254519
Purification and Characterization of Rat Skeletal Muscle Acetyl-CoA CarboxylaseQ41678128
Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascadeQ42160057
Role of AMPKalpha2 in basal, training-, and AICAR-induced GLUT4, hexokinase II, and mitochondrial protein expression in mouse muscleQ42500929
Effect of fiber type and nutritional state on AICAR- and contraction-stimulated glucose transport in rat muscleQ43989934
Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exerciseQ45071070
AMP kinase activation with AICAR simultaneously increases fatty acid and glucose oxidation in resting rat soleus muscleQ46387224
Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinaseQ50337120
Activation of Malonyl-CoA Decarboxylase in Rat Skeletal Muscle by Contraction and the AMP-activated Protein Kinase Activator 5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranosideQ58088416
Exercise diminishes the activity of acetyl-CoA carboxylase in human muscleQ58108348
P433issue6
P921main subjectfatty acidQ61476
P304page(s)E1572-9
P577publication date2007-10-09
P1433published inAmerican Journal of Physiology - Endocrinology and MetabolismQ15765671
P1476titleLKB1 and the regulation of malonyl-CoA and fatty acid oxidation in muscle
P478volume293

Reverse relations

cites work (P2860)
Q515961465'-AMP activated protein kinase α2 controls substrate metabolism during post-exercise recovery via regulation of pyruvate dehydrogenase kinase 4.
Q37401928AMP-activated protein kinase control of fat metabolism in skeletal muscle
Q46094264AMP-activated protein kinase response to contractions and treatment with the AMPK activator AICAR in young adult and old skeletal muscle
Q54345958AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice.
Q45915520AMPK-independent pathways regulate skeletal muscle fatty acid oxidation.
Q26995682AMPK: a cellular metabolic and redox sensor. A minireview
Q33945472Ablation of LKB1 in the heart leads to energy deprivation and impaired cardiac function
Q54116659Adipocyte-specific deletion of Lkb1 and mTOR protects against high-fat diet induced obesity but results in insulin resistance.
Q37665451BRCA1 is a novel regulator of metabolic function in skeletal muscle
Q37110520Contraction and AICAR stimulate IL-6 vesicle depletion from skeletal muscle fibers in vivo
Q36363321Diacylglycerol kinase-δ regulates AMPK signaling, lipid metabolism, and skeletal muscle energetics
Q57713559Dietary supplementation with vitamin E and C attenuates dexamethasone-induced glucose intolerance in rats
Q41221005Does long-term metformin treatment increase cardiac lipoprotein lipase?
Q34647665Effect of LKB1 deficiency on mitochondrial content, fibre type and muscle performance in the mouse diaphragm
Q51752375Hunting for the SNARK in metabolic disease.
Q42245821IL-6 indirectly modulates the induction of glyceroneogenic enzymes in adipose tissue during exercise
Q42959174Isoproterenol stimulates 5'-AMP-activated protein kinase and fatty acid oxidation in neonatal hearts.
Q33919567LKB1 and AMPK and the regulation of skeletal muscle metabolism
Q37543834LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism
Q45827485LKB1 downregulation may be independent of promoter methylation or FOXO3 expression in head and neck cancer.
Q36795983LKB1 regulates lipid oxidation during exercise independently of AMPK
Q37218021Liver kinase B1 inhibits the expression of inflammation-related genes postcontraction in skeletal muscle
Q41841568Lkb1 deletion promotes ectopic lipid accumulation in muscle progenitor cells and mature muscles
Q42044480Lkb1 is indispensable for skeletal muscle development, regeneration, and satellite cell homeostasis
Q39076554Lkb1 regulation of skeletal muscle development, metabolism and muscle progenitor cell homeostasis.
Q37234626Mitochondrial and performance adaptations to exercise training in mice lacking skeletal muscle LKB1
Q35979184Pancreatic β-Cell Dysfunction in Diet-Induced Obese Mice: Roles of AMP-Kinase, Protein Kinase Cε, Mitochondrial and Cholesterol Metabolism, and Alterations in Gene Expression
Q30494897Skeletal muscle dysfunction in muscle-specific LKB1 knockout mice
Q45243791Skeletal muscle fat metabolism after exercise in humans: influence of fat availability
Q57476059The Role of AMPK in the Regulation of Skeletal Muscle Size, Hypertrophy, and Regeneration
Q44821884Thyroid hormone effects on LKB1, MO25, phospho-AMPK, phospho-CREB, and PGC-1alpha in rat muscle