Development of a toxicogenomics in vitro assay for the efficient characterization of compounds

scientific article published in March 2006

Development of a toxicogenomics in vitro assay for the efficient characterization of compounds is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2217/14622416.7.2.177
P698PubMed publication ID16515397

P2093author name stringYi Yang
Jeffrey F Waring
Rita Ciurlionis
Stephen J Abel
P2860cites workSummaries of Affymetrix GeneChip probe level dataQ27860888
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Clustering of hepatotoxins based on mechanism of toxicity using gene expression profilesQ28213099
Molecular cloning of the peroxisome proliferator-induced 46-kDa cytosolic acyl-CoA thioesterase from mouse and rat liver--recombinant expression in Escherichia coli, tissue expression, and nutritional regulationQ28579822
Can the pharmaceutical industry reduce attrition rates?Q29616077
Platform influence on DNA microarray data in postmortem brain researchQ30984419
Differential gene regulation in human versus rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) alpha. PPAR alpha fails to induce peroxisome proliferation-associated genes in human cells independently of the level of receptor exQ33952364
Toxicogenomics in drug discovery: from preclinical studies to clinical trialsQ35937248
Agonist and chemopreventative ligands induce differential transcriptional cofactor recruitment by aryl hydrocarbon receptorQ36139135
Induction of the acyl-coenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoterQ38292537
A gene expression signature for oxidant stress/reactive metabolites in rat liverQ38335137
Identification of novel TCDD-regulated genes by microarray analysis.Q40466550
Toxicogenomics-based discrimination of toxic mechanism in HepG2 human hepatoma cellsQ40736468
Predicting human safety: screening and computational approachesQ40744635
Signal transduction-mediated activation of the aryl hydrocarbon receptor in rat hepatoma H4IIE cellsQ41066706
Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugsQ42551374
Molecular cloning and expression of cDNA encoding rat brain cytosolic acyl-coenzyme A thioester hydrolaseQ42630082
Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicityQ43588948
Assessment of hepatocytes and liver slices as in vitro test systems to predict in vivo gene expressionQ44495563
Effects of peroxisome proliferator-activated receptor alpha activation on pathways contributing to cholesterol homeostasis in rat hepatocytes.Q44967119
Real-time TaqMan PCR as a specific and more sensitive alternative to the branched-chain DNA assay for quantitation of simian immunodeficiency virus RNA.Q45738726
P433issue2
P921main subjecttoxicogenomicsQ841450
P304page(s)177-186
P577publication date2006-03-01
P1433published inPharmacogenomicsQ15724625
P1476titleDevelopment of a toxicogenomics in vitro assay for the efficient characterization of compounds
P478volume7

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cites work (P2860)
Q38025961A decade of toxicogenomic research and its contribution to toxicological science
Q27013780Advancing human health risk assessment: integrating recent advisory committee recommendations
Q51467325Biomarker classifiers for identifying susceptible subpopulations for treatment decisions.
Q21562369Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human
Q57477472Establishment of a novel safety assessment method for vaccine adjuvant development
Q36726630Gene expression profiling and its practice in drug development
Q37264550Identifying genetic components of drug response in mice
Q37618225Mitochondrial gene profiling: translational perspectives
Q28469153PPARalpha siRNA-treated expression profiles uncover the causal sufficiency network for compound-induced liver hypertrophy

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