A selective small molecule IkappaB Kinase beta inhibitor blocks nuclear factor kappaB-mediated inflammatory responses in human fibroblast-like synoviocytes, chondrocytes, and mast cells

scientific article published on 8 March 2006

A selective small molecule IkappaB Kinase beta inhibitor blocks nuclear factor kappaB-mediated inflammatory responses in human fibroblast-like synoviocytes, chondrocytes, and mast cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1124/JPET.105.097584
P698PubMed publication ID16525037

P2093author name stringHong Cheng
Chris Fraser
Yajun Xu
Danyi Wen
Michael Hepperle
Bruce D Jaffee
Geraldine Harriman
Lisa Schopf
Andrew Bielecki
Jennifer Dasilva
Timothy D Ocain
Yuhua Nong
Jennifer G Morgan
Marie Keaveney
Pranoti Gangurde
P433issue3
P407language of work or nameEnglishQ1860
P921main subjecthuman fibroblastQ101404861
mast cellQ191989
P304page(s)989-1001
P577publication date2006-03-08
P1433published inJournal of Pharmacology and Experimental TherapeuticsQ1500272
P1476titleA selective small molecule IkappaB Kinase beta inhibitor blocks nuclear factor kappaB-mediated inflammatory responses in human fibroblast-like synoviocytes, chondrocytes, and mast cells
P478volume317

Reverse relations

cites work (P2860)
Q4619745711th annual Inflammatory and Immune Diseases Drug Discovery and Development Summit 12-13 March 2007, San Francisco, USA.
Q37976467A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets
Q54379487A novel IKKα inhibitor, noraristeromycin, blocks the chronic inflammation associated with collagen-induced arthritis in mice.
Q35156421A novel carboline derivative inhibits nitric oxide formation in macrophages independent of effects on tumor necrosis factor α and interleukin-1β expression
Q33834752A proto-oncogene BCL6 is up-regulated in the bone marrow microenvironment in multiple myeloma cells
Q37036746Advances in targeting IKK and IKK-related kinases for cancer therapy
Q89422998Alternative NF-κB signaling promotes colorectal tumorigenesis through transcriptionally upregulating Bcl-3
Q40440899B-cell-derived lymphotoxin promotes castration-resistant prostate cancer
Q37201984Biologic sequelae of I{kappa}B kinase (IKK) inhibition in multiple myeloma: therapeutic implications
Q37291635Bortezomib induces canonical nuclear factor-kappaB activation in multiple myeloma cells
Q90468258Breaking the vicious loop between inflammation, oxidative stress and coagulation, a novel anti-thrombus insight of nattokinase by inhibiting LPS-induced inflammation and oxidative stress
Q37615916Chemical biology of inflammatory cytokine signaling
Q33395224Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen
Q36794899Developments in the synovial biology field 2006.
Q39996123Dexamethasone-induced expression of the glucocorticoid response gene lipocalin 2 in chondrocytes.
Q36094024Dihydromyricetin suppresses inflammatory responses in vitro and in vivo through inhibition of IKKβ activity in macrophages
Q34454541Discovery of a novel IKK-β inhibitor by ligand-based virtual screening techniques
Q33812773Expression and functional role of adenosine receptors in regulating inflammatory responses in human synoviocytes
Q33737707Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation
Q34133753I-kappa-kinase-2 (IKK-2) inhibition potentiates vincristine cytotoxicity in non-Hodgkin's lymphoma
Q58113127IL-1-induced JAK/STAT signaling is antagonized by TGF-beta to shape CAF heterogeneity in pancreatic ductal adenocarcinoma
Q37310621Immunomodulatory and anti-inflammatory effects of chondroitin sulphate
Q41575754Inhibitory Kappa B Kinase α (IKKα) Inhibitors That Recapitulate Their Selectivity in Cells against Isoform-Related Biomarkers
Q37907354Inhibitory kappa B Kinases as targets for pharmacological regulation
Q38778339Isatin Derived Spirocyclic Analogues with α-Methylene-γ-butyrolactone as Anticancer Agents: A Structure-Activity Relationship Study
Q38724839Isoacteoside, a dihydroxyphenylethyl glycoside, exhibits anti-inflammatory effects through blocking toll-like receptor 4 dimerization.
Q37447488IκB kinase b Mediating the Downregulation of p53 and p21 by Lipopolysaccharide in Human Papillomavirus 16+ Cervical Cancer Cells
Q90574004Latent, Immunosuppressive Nature of Poly(lactic-co-glycolic acid) Microparticles
Q35835370Lipopolysaccharide and hypoxia significantly alters interleukin-8 and macrophage chemoattractant protein-1 production by human fibroblasts but not fibrosis related factors.
Q48105513Long-acting β2-agonists promote glucocorticoid-mediated repression of NF-κB by enhancing expression of the feedback regulator TNFAIP3.
Q55463750Matrix metalloproteinase-1 and -2 as markers of mineral bone disease in chronic kidney disease patients.
Q39563568Matrix metalloproteinase-13 expression in IL-1β-treated chondrocytes by activation of the p38 MAPK/c-Fos/AP-1 and JAK/STAT pathways
Q38644746Modulation of NF-κB Signaling as a Therapeutic Target in Autoimmunity.
Q36544693Mutation of cysteine 46 in IKK-beta increases inflammatory responses
Q36709522NF-kappa B as a therapeutic target in autoimmune disease.
Q28546967Pentacyclic Triterpenoids Inhibit IKKβ Mediated Activation of NF-κB Pathway: In Silico and In Vitro Evidences
Q90859276Procyanidin A1 Alleviates Inflammatory Response induced by LPS through NF-κB, MAPK, and Nrf2/HO-1 Pathways in RAW264.7 cells
Q50872022Protective effects of Nebivolol against interleukin-1β (IL-1β)-induced type II collagen destruction mediated by matrix metalloproteinase-13 (MMP-13).
Q55171215Role of Toll-Like Receptor 4 on Osteoblast Metabolism and Function.
Q36204370Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase
Q37214209Signalling, inflammation and arthritis: Crossed signals: the role of interleukin-15 and -18 in autoimmunity.
Q37308018Targeting the NF-kappaB pathway in asthma and chronic obstructive pulmonary disease.
Q36778047Targeting the NF-κB and mTOR pathways with a quinoxaline urea analog that inhibits IKKβ for pancreas cancer therapy
Q92050583The Role of NF-κB in Physiological Bone Development and Inflammatory Bone Diseases: Is NF-κB Inhibition "Killing Two Birds with One Stone"?
Q49463915The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts
Q37781917Therapeutic opportunities in fibroblasts in inflammatory arthritis
Q41168560Total tanshinones exhibits anti-inflammatory effects through blocking TLR4 dimerization via the MyD88 pathway.
Q46667078Transcriptional repression by the HDAC4-RelB-p52 complex regulates multiple myeloma survival and growth
Q64880703Tumour-Derived Laminin α5 (LAMA5) Promotes Colorectal Liver Metastasis Growth, Branching Angiogenesis and Notch Pathway Inhibition.
Q28268290Use of cell permeable NBD peptides for suppression of inflammation

Search more.