Blockade of CB1 cannabinoid receptor alters gut microbiota and attenuates inflammation and diet-induced obesity.

scientific article published on 15 November 2017

Blockade of CB1 cannabinoid receptor alters gut microbiota and attenuates inflammation and diet-induced obesity. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-017-15154-6
P8608Fatcat IDrelease_x3f5ynf2knfttbq2j4u3rjkk5e
P932PMC publication ID5688117
P698PubMed publication ID29142285

P50authorReilly EnosQ42780518
Mitra S GanewattaQ60168725
P2093author name stringMitzi Nagarkatti
Prakash Nagarkatti
E Angela Murphy
Kandy T Velazquez
Chuanbing Tang
Pegah Mehrpouya-Bahrami
Kumaraswamy Naidu Chitrala
Jamie McCellan
P2860cites workMicrobial translocation is a cause of systemic immune activation in chronic HIV infectionQ22251054
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Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in manQ26776977
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Leptin-regulated endocannabinoids are involved in maintaining food intakeQ28211969
CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivityQ28242954
Food intake-independent effects of CB1 antagonism on glucose and lipid metabolismQ28573389
Metabolic endotoxemia initiates obesity and insulin resistanceQ29547720
The gut microbiota shapes intestinal immune responses during health and diseaseQ29547727
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesityQ29615051
Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5Q29615053
Macrophage inflammatory protein 1-alpha (MIP-1 alpha ) triggers migration and signaling cascades mediating survival and proliferation in multiple myeloma (MM) cellsQ44265469
CB(1) blockade-induced weight loss over 48 weeks decreases liver fat in proportion to weight loss in humans.Q45908497
The effects of rimonabant on brown adipose tissue in rat: implications for energy expenditure.Q46213429
The CB1 receptor antagonist rimonabant reverses the diet-induced obesity phenotype through the regulation of lipolysis and energy balanceQ46595047
Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose productionQ48145978
Differences in goblet cell differentiation between Crohn's disease and ulcerative colitis.Q51771968
Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity.Q54468190
CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding proteinQ29615189
Richness of human gut microbiome correlates with metabolic markersQ29617365
Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeabilityQ29617378
Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiomeQ29617424
Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium.Q30962119
Rapid determination of short-chain fatty acids in colonic contents and faeces of humans and rats by acidified water-extraction and direct-injection gas chromatographyQ33224612
An improved dual-indexing approach for multiplexed 16S rRNA gene sequencing on the Illumina MiSeq platformQ34039945
The endocannabinoid system links gut microbiota to adipogenesisQ34078880
Differential modulation by Akkermansia muciniphila and Faecalibacterium prausnitzii of host peripheral lipid metabolism and histone acetylation in mouse gut organoids.Q34093446
Differential expression of cannabinoid receptors in the human colon: cannabinoids promote epithelial wound healingQ34440704
Short-Chain Fatty Acids Protect Against High-Fat Diet-Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat OxidationQ34463631
Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR SignalingQ34491604
Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trialQ34494637
Extracellular vesicles derived from gut microbiota, especially Akkermansia muciniphila, protect the progression of dextran sulfate sodium-induced colitisQ35034704
Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesisQ35081904
Reducing the dietary omega-6:omega-3 utilizing α-linolenic acid; not a sufficient therapy for attenuating high-fat-diet-induced obesity development nor related detrimental metabolic and adipose tissue inflammatory outcomesQ35148099
Modulation of Mucosal Immune Response, Tolerance, and Proliferation in Mice Colonized by the Mucin-Degrader Akkermansia muciniphila.Q35157719
Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant miceQ35405358
Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndromeQ35570155
Is the gut microbiota a new factor contributing to obesity and its metabolic disorders?Q35725309
Effect of the cannabinoid receptor-1 antagonist rimonabant on inflammation in mice with diet-induced obesityQ35738935
Cannabinoid-based drugs as anti-inflammatory therapeuticsQ36111923
Controlled downregulation of the cannabinoid CB1 receptor provides a promising approach for the treatment of obesity and obesity-derived type 2 diabetesQ36373581
Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and LynQ36377155
Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastaseQ36377312
Host remodeling of the gut microbiome and metabolic changes during pregnancyQ36421887
Probiotics modulated gut microbiota suppresses hepatocellular carcinoma growth in miceQ36658938
Microbial metabolite butyrate facilitates M2 macrophage polarization and functionQ36814971
Peripheral endocannabinoid dysregulation in obesity: relation to intestinal motility and energy processing induced by food deprivation and re-feedingQ37376946
Production of endocannabinoids by activated T cells and B cells modulates inflammation associated with delayed-type hypersensitivityQ37551092
Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity.Q37695058
Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasisQ37855523
Inhibiting CB1 receptors improves lipogenesis in an in vitro non-alcoholic fatty liver disease model.Q38939502
Chylomicrons promote intestinal absorption of lipopolysaccharidesQ39936075
Anti-inflammatory effects of short chain fatty acids in IFN-gamma-stimulated RAW 264.7 murine macrophage cells: involvement of NF-kappaB and ERK signaling pathwaysQ40197858
Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-kappaB independently of platelet-activating factorQ40638952
The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents.Q42090677
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesggplot2Q326489
ImageJQ1659584
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectCNR2Q17907844
cannabinoid receptorQ421237
cannabinoidsQ422936
P304page(s)15645
P577publication date2017-11-15
P1433published inScientific ReportsQ2261792
P1476titleBlockade of CB1 cannabinoid receptor alters gut microbiota and attenuates inflammation and diet-induced obesity
P478volume7

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cites work (P2860)
Q64263349Cannabinoid Receptor 1 Blockade Attenuates Obesity and Adipose Tissue Type 1 Inflammation Through miR-30e-5p Regulation of Delta-Like-4 in Macrophages and Consequently Downregulation of Th1 Cells
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Q92478893Countering the Modern Metabolic Disease Rampage With Ancestral Endocannabinoid System Alignment
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Q98177611Investigating the Mechanistic Differences of Obesity-Inducing Lactobacillus kefiranofaciens M1 and Anti-obesity Lactobacillus mali APS1 by Microbolomics and Metabolomics
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Q89509774Metabolically Healthy Obesity-Heterogeneity in Definitions and Unconventional Factors
Q57165498New approaches and challenges to targeting the endocannabinoid system
Q89920189Obesity Affects the Microbiota-Gut-Brain Axis and the Regulation Thereof by Endocannabinoids and Related Mediators
Q90479312Phytocannabinoids: Useful Drugs for the Treatment of Obesity? Special Focus on Cannabidiol
Q89964094Progress in Genetic Polymorphisms Related to Lipid Disturbances Induced by Atypical Antipsychotic Drugs
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Q61803411Role of Dietary Lipids in Modulating Inflammation through the Gut Microbiota
Q92613057Role of microRNA in CB1 antagonist-mediated regulation of adipose tissue macrophage polarization and chemotaxis during diet-induced obesity
Q92435620The role of gut microbiota in non-alcoholic fatty liver disease: pathways of mechanisms

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