A Ser75-to-Asp phospho-mimicking mutation in Src accelerates ageing-related loss of retinal ganglion cells in mice

scientific article published in December 2017

A Ser75-to-Asp phospho-mimicking mutation in Src accelerates ageing-related loss of retinal ganglion cells in mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-017-16872-7
P932PMC publication ID5711949
P698PubMed publication ID29196663

P2093author name stringKenji Kashiwagi
Shuichiro Maeda
Goro Kato
Sadahiro Ito
P2860cites workNewest findings on the oldest oncogene; how activated src does itQ24313514
The role of the Rho/ROCK signaling pathway in inhibiting axonal regeneration in the central nervous systemQ26775044
Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegenerationQ28140796
Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neuronsQ28568084
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in miceQ29547898
Phosphorylation of unique domains of Src family kinasesQ30009341
Lipid binding by the Unique and SH3 domains of c-Src suggests a new regulatory mechanismQ30009924
c-Src is required for glial cell line-derived neurotrophic factor (GDNF) family ligand-mediated neuronal survival via a phosphatidylinositol-3 kinase (PI-3K)-dependent pathway.Q32061981
The many faces of Src: multiple functions of a prototypical tyrosine kinaseQ77436410
Inactivation of the Akt survival pathway during photoreceptor apoptosis in the retinal degeneration mouseQ82973505
Mitosis-specific phosphorylation of p60c-src by p34cdc2-associated protein kinaseQ46402776
Müller glia factors induce survival and neuritogenesis of peripheral and central neuronsQ46692536
Presence of calpain-induced proteolysis in retinal degeneration and dysfunction in a rat model of acute ocular hypertensionQ46984216
Regulation of c-Src activity in glutamate-induced neurodegenerationQ48136080
Neurones express high levels of a structurally modified, activated form of pp60c-srcQ48462400
Multi-phosphorylation of the intrinsically disordered unique domain of c-Src studied by in-cell and real-time NMR spectroscopyQ48623512
Developmental alteration of the expression and kinase activity of cyclin-dependent kinase 5 (Cdk5)/p35nck5a in the rat retinaQ48856672
The prevalence of primary open-angle glaucoma in Japanese: the Tajimi Study.Q53612490
pp60c-src is developmentally regulated in the neural retinaQ60654496
A replacement vector used to introduce subtle mutations into mouse genesQ70841675
Cdc2-mediated modulation of pp60c-src activityQ72724798
Neuron-specific Cdk5 kinase is responsible for mitosis-independent phosphorylation of c-Src at Ser75 in human Y79 retinoblastoma cellsQ73139196
Production of mouse ES cells homozygous for Cdk5-phosphorylated site mutation in c-Src allelesQ73514247
Apoptosis of central and peripheral neurons can be prevented with cyclin-dependent kinase/mitogen-activated protein kinase inhibitorsQ74384001
The proteome of central and peripheral retina with progression of age-related macular degeneration.Q33244626
Cdk5 activity in the brain - multiple paths of regulationQ33687591
Inhibition of reactive gliosis attenuates excitotoxicity-mediated death of retinal ganglion cellsQ33869580
Viral vector-mediated downregulation of RhoA increases survival and axonal regeneration of retinal ganglion cellsQ34139680
The RNA binding protein RBPMS is a selective marker of ganglion cells in the mammalian retinaQ34390563
v-Src's hold over actin and cell adhesionsQ34627236
Activation of TLR3 promotes the degeneration of retinal ganglion cells by upregulating the protein levels of JNK3Q34986464
Cdk5 targets active Src for ubiquitin-dependent degradation by phosphorylating Src(S75).Q35199261
Oxidative stress in glaucomatous neurodegeneration: mechanisms and consequencesQ35677091
Cyclin-dependent kinase-5 in neurodegeneration.Q35686119
Src kinases: a hub for NMDA receptor regulationQ35701114
Retinal neurodegeneration in experimental glaucoma.Q35819924
Rho/ROCK pathway and neural regeneration: a potential therapeutic target for central nervous system and optic nerve damageQ35924101
ROCK and Rho: biochemistry and neuronal functions of Rho-associated protein kinasesQ36954083
Role of p34cdc2-mediated phosphorylations in two-step activation of pp60c-src during mitosisQ37141592
Cdk5-dependent regulation of Rho activity, cytoskeletal contraction, and epithelial cell migration via suppression of Src and p190RhoGAPQ37452569
Neural cell cycle dysregulation and central nervous system diseasesQ37556914
Shp-2 regulates the TrkB receptor activity in the retinal ganglion cells under glaucomatous stress.Q38322834
Control of neurite outgrowth by RhoA inactivationQ38469173
Mini-Review: Impaired Axonal Transport and GlaucomaQ38540617
Rho kinase is required to prevent retinal axons from entering the contralateral optic nerveQ38561283
Maturation-promoting factor and the regulation of the cell cycleQ38782615
Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivoQ40112247
ROCK inhibition and CNTF interact on intrinsic signalling pathways and differentially regulate survival and regeneration in retinal ganglion cellsQ40146314
Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories.Q41075059
Novel phosphorylation at a mitotic site, serine 75, in human pp60c-src from unsynchronized human tumor cells having a spherical morphologyQ41271388
Targeting Cdk5 activity in neuronal degeneration and regenerationQ41720010
c-Src deactivation by the polyphenol 3-O-caffeoylquinic acid abrogates reactive oxygen species-mediated glutamate release from microglia and neuronal excitotoxicity.Q42469966
Purified maturation promoting factor phosphorylates pp60c-src at the sites phosphorylated during fibroblast mitosisQ42798083
Altered phosphorylation and activation of pp60c-src during fibroblast mitosisQ42804505
Src-dependent phosphorylation of ROCK participates in regulation of focal adhesion dynamics.Q42820756
Src inhibition reduces NR2B surface expression and synaptic plasticity in the amygdalaQ42957537
Comparative proteomic analyses of macular and peripheral retina of cynomolgus monkeys (Macaca fascicularis).Q43059351
Combined inhibition of Cdk5 and ROCK additively increase cell survival, but not the regenerative response in regenerating retinal ganglion cellsQ43270855
Involvement of cyclin-dependent kinases in axotomy-induced retinal ganglion cell deathQ43968047
Cdc2 phosphorylation of BAD links the cell cycle to the cell death machineryQ44017737
Comparative expression profiles of Trk receptors and Shc-related phosphotyrosine adapters during retinal development: potential roles of N-Shc/ShcC in brain-derived neurotrophic factor signal transduction and modulationQ44059838
Expression of the myelin basic protein gene in transgenic mice expressing human neurotropic virus, JCV, early proteinQ45789829
ROCK inhibition promotes adult retinal ganglion cell neurite outgrowth only in the presence of growth promoting factors.Q45970067
Structural characterization of the natively unfolded N-terminal domain of human c-Src kinase: insights into the role of phosphorylation of the unique domain.Q45972692
Brn3a as a marker of retinal ganglion cells: qualitative and quantitative time course studies in naive and optic nerve-injured retinas.Q46098774
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectretinal ganglion cellQ927337
P304page(s)16779
P577publication date2017-12-01
P1433published inScientific ReportsQ2261792
P1476titleA Ser75-to-Asp phospho-mimicking mutation in Src accelerates ageing-related loss of retinal ganglion cells in mice
P478volume7

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cites work (P2860)
Q64071303Nonphosphorylatable Src Ser75 Mutation Increases Ethanol Preference and Consumption in Mice
Q64121660The M muscarinic acetylcholine receptor subtype is important for retinal neuron survival in aging mice

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