Comparison of four 11C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176-based on recent publications that measured specific-to-non-displaceable ratios

scientific article published on 16 October 2017

Comparison of four 11C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176-based on recent publications that measured specific-to-non-displaceable ratios is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1092244731
P356DOI10.1186/S13550-017-0334-8
P932PMC publication ID5643834
P698PubMed publication ID29038960

P50authorRoger N. GunnQ41909429
David R OwenQ43864640
Eugenii A. RabinerQ56097267
Masamichi IkawaQ61822785
Masahiro FujitaQ92681679
P2093author name stringMasato Kobayashi
Robert B Innis
Victor W Pike
Sami S Zoghbi
Sanjay Telu
Mohamad B Haskali
P2860cites workAn 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28Q24599479
Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effectsQ28249253
Comparison of [(11)C]-(R)-PK 11195 and [(11)C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: Implications for positron emission tomographic imaging of this inflammation biomarkerQ33706576
Determination of [(11)C]PBR28 binding potential in vivo: a first human TSPO blocking studyQ33729262
Synthesis and evaluation of translocator 18 kDa protein (TSPO) positron emission tomography (PET) radioligands with low binding sensitivity to human single nucleotide polymorphism rs6971.Q34408079
Mixed-affinity binding in humans with 18-kDa translocator protein ligandsQ35181349
Kinetic analysis in healthy humans of a novel positron emission tomography radioligand to image the peripheral benzodiazepine receptor, a potential biomarker for inflammationQ36492494
Brain and whole-body imaging in nonhuman primates of [11C]PBR28, a promising PET radioligand for peripheral benzodiazepine receptorsQ36509182
11C-ER176, a Radioligand for 18-kDa Translocator Protein, Has Adequate Sensitivity to Robustly Image All Three Affinity Genotypes in Human BrainQ38794304
Measuring drug occupancy in the absence of a reference region: the Lassen plot re-visitedQ42414770
(11)C-DPA-713 has much greater specific binding to translocator protein 18 kDa (TSPO) in human brain than (11)C-( R)-PK11195.Q47771193
P433issue1
P304page(s)84
P577publication date2017-10-16
P1433published inEJNMMI ResearchQ27723773
P1476titleComparison of four 11C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176-based on recent publications that measured specific-to-non-displaceable ratios
P478volume7

Reverse relations

cites work (P2860)
Q62668992Confirmation of Specific Binding of the 18-kDa Translocator Protein (TSPO) Radioligand [18F]GE-180: a Blocking Study Using XBD173 in Multiple Sclerosis Normal Appearing White and Grey Matter
Q100633713Development of a non-radiometric method for measuring the arterial input function of a 11C-labeled PET radiotracer
Q58605846Early microglial activation and peripheral inflammation in dementia with Lewy bodies
Q92244027Natalizumab treatment reduces microglial activation in the white matter of the MS brain
Q92000951Neuroinflammation and Functional Connectivity in Alzheimer's Disease: Interactive Influences on Cognitive Performance
Q92234366Neuroinflammation in frontotemporal lobar degeneration revealed by 11 C-PBR28 PET
Q100960809Neuroinflammation in psychiatric disorders: PET imaging and promising new targets
Q100960869PET imaging of neuroinflammation in neurological disorders
Q52589352Positron Emission Tomography Studies of the Glial Cell Marker Translocator Protein in Patients With Psychosis: A Meta-analysis Using Individual Participant Data.
Q88960978TSPO-PET imaging using [18F]PBR06 is a potential translatable biomarker for treatment response in Huntington's disease: preclinical evidence with the p75NTR ligand LM11A-31
Q60048853Test-retest reliability and convergent validity of (R)-[C]PK11195 outcome measures without arterial input function
Q55259433[125 I]IodoDPA-713 Binding to 18 kDa Translocator Protein (TSPO) in a Mouse Model of Intracerebral Hemorrhage: Implications for Neuroimaging.

Search more.