Despite disorganized synapse structure, Th2 cells maintain directional delivery of CD40L to antigen-presenting B cells

scientific article published on 12 October 2017

Despite disorganized synapse structure, Th2 cells maintain directional delivery of CD40L to antigen-presenting B cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PONE.0186573
P932PMC publication ID5638602
P698PubMed publication ID29023539

P50authorDavid C. ParkerQ37828481
P2093author name stringJennifer L Gardell
P2860cites workT cells use two directionally distinct pathways for cytokine secretion.Q45948164
Imaging of germinal center selection events during affinity maturationQ46722429
CD40L is transferred to antigen-presenting B cells during delivery of T-cell help.Q51381689
Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers.Q54167674
Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer.Q54618275
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Supported Planar Bilayers for Study of the Immunological SynapseQ57962197
T–B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reactionQ59071961
Characterization of the effector mechanism of help for antigen-presenting and bystander resting B cell growth mediated by Ia-restricted Th2 helper T cell linesQ70061900
Mice deficient for the CD40 ligandQ72610555
Live-cell dynamics and the role of costimulation in immunological synapse formationQ78551152
Follicular helper T cells: lineage and locationQ24647274
The specific interaction of helper T cells and antigen-presenting B cells. IV. Membrane and cytoskeletal reorganizations in the bound T cell as a function of antigen doseQ24681794
A brief history of T cell help to B cellsQ26825185
Remodelling of cortical actin where lytic granules dock at natural killer cell immune synapses revealed by super-resolution microscopyQ27320914
Natural killer cell lytic granule secretion occurs through a pervasive actin network at the immune synapseQ27320971
Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporterQ30498133
Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiationQ33829736
Preformed CD40L is stored in Th1, Th2, Th17, and T follicular helper cells as well as CD4+ 8- thymocytes and invariant NKT cells but not in Treg cellsQ34170759
CD40 molecules induce down-modulation and endocytosis of T cell surface T cell-B cell activating molecule/CD40-L. Potential role in regulating helper effector functionQ34290903
T cell-dependent B cell activationQ34363600
Cyclosporine-resistant, Rab27a-independent mobilization of intracellular preformed CD40 ligand mediates antigen-specific T cell help in vitro.Q35091423
Preformed CD40 ligand exists in secretory lysosomes in effector and memory CD4+ T cells and is quickly expressed on the cell surface in an antigen-specific mannerQ36007588
The biological outcome of CD40 signaling is dependent on the duration of CD40 ligand expression: reciprocal regulation by interleukin (IL)-4 and IL-12.Q36371081
Th1 and Th2 cells form morphologically distinct immunological synapses.Q36740495
Secretory mechanisms in cell-mediated cytotoxicityQ36824188
CD4⁺ follicular helper T cell infiltration predicts breast cancer survivalQ36966923
Transfer of extracellular vesicles during immune cell-cell interactionsQ37087729
Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapseQ37629486
Microtubule-organizing center polarity and the immunological synapse: protein kinase C and beyondQ38051634
Cell biology of cytotoxic and helper T cell functions: immunofluorescence microscopic studies of single cells and cell couplesQ38252557
T follicular helper cell differentiation, function, and roles in diseaseQ38264816
Opposing Development of Cytotoxic and Follicular Helper CD4 T Cells Controlled by the TCF-1-Bcl6 Nexus.Q40469638
CD40 and its ligand.Q41096679
Dynamic signaling by T follicular helper cells during germinal center B cell selection.Q42406102
Supported Planar Bilayers for the Formation of Study of Immunological Synapses and KinapseQ42776493
A subset of CD4+ memory T cells contains preformed CD40 ligand that is rapidly but transiently expressed on their surface after activation through the T cell receptor complexQ42942895
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)e0186573
P577publication date2017-10-12
P1433published inPLOS OneQ564954
P1476titleDespite disorganized synapse structure, Th2 cells maintain directional delivery of CD40L to antigen-presenting B cells
P478volume12

Reverse relations

cites work (P2860)
Q92751513SLAMF6 clustering is required to augment T cell activation
Q58785757Synaptic Interactions in Germinal Centers

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