Metformin induces cell cycle arrest at the G1 phase through E2F8 suppression in lung cancer cells

scientific article published on 6 October 2017

Metformin induces cell cycle arrest at the G1 phase through E2F8 suppression in lung cancer cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.21552
P932PMC publication ID5731892
P698PubMed publication ID29254182

P2093author name stringYujin Kim
Hong Kwan Kim
Young Mog Shim
Duk-Hwan Kim
Joungho Han
Bo Bin Lee
Dong Hao Jin
P2860cites workNuclear overexpression of the E2F3 transcription factor in human lung cancer.Q53602672
Activation and repression of p21(WAF1/CIP1) transcription by RB binding proteinsQ74465220
E2F1 overexpression correlates with thymidylate synthase and survivin gene expressions and tumor proliferation in non small-cell lung cancerQ80139021
Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcriptionQ24336562
E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genesQ24633900
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resourcesQ27860739
Combinational Therapy Enhances the Effects of Anti-IGF-1R mAb Figitumumab to Target Small Cell Lung CancerQ28547364
p21 in cancer: intricate networks and multiple activitiesQ30436015
A20 modulates lipid metabolism and energy production to promote liver regenerationQ33855522
The E2F1-3 transcription factors are essential for cellular proliferation.Q34102966
Carnitine palmitoyltransferase 1A (CPT1A): a transcriptional target of PAX3-FKHR and mediates PAX3-FKHR-dependent motility in alveolar rhabdomyosarcoma cellsQ34245749
Antiproliferative action of metformin in human lung cancer cell linesQ34265863
Emerging roles of E2Fs in cancer: an exit from cell cycle controlQ35009182
Survival of patients with stage IV lung cancer with diabetes treated with metforminQ35153493
Metformin inhibits the proliferation of A549/CDDP cells by activating p38 mitogen-activated protein kinaseQ35224272
E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis.Q35837977
The E2F family: specific functions and overlapping interestsQ35945854
E2F2 induction in related to cell proliferation and poor prognosis in non-small cell lung carcinomaQ36261436
E2F8 as a Novel Therapeutic Target for Lung CancerQ36294944
Overexpression of MAPK15 in gastric cancer is associated with copy number gain and contributes to the stability of c-JunQ36299630
Structural insights into the DNA-binding specificity of E2F family transcription factorsQ36392339
Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK.Q36896122
E2f8 mediates tumor suppression in postnatal liver developmentQ37137905
Upregulation of E2F8 promotes cell proliferation and tumorigenicity in breast cancer by modulating G1/S phase transition.Q37269121
Atypical E2Fs: new players in the E2F transcription factor familyQ37388181
Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding proteinQ37417220
Metformin sensitizes EGFR-TKI-resistant human lung cancer cells in vitro and in vivo through inhibition of IL-6 signaling and EMT reversalQ39014053
The antidiabetic drug metformin inhibits the proliferation of bladder cancer cells in vitro and in vivoQ39042097
Synergistic effects of metformin treatment in combination with gefitinib, a selective EGFR tyrosine kinase inhibitor, in LKB1 wild-type NSCLC cell lines.Q39149019
Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells.Q39670303
E2F8 contributes to human hepatocellular carcinoma via regulating cell proliferation.Q39752834
Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitroQ39883174
The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level.Q40021818
A role for E2F1 in Ras activation of p21(WAF1/CIP1) transcriptionQ40895969
Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development.Q43058346
Metformin suppresses hepatocellular carcinoma cell growth through induction of cell cycle G1/G0 phase arrest and p21CIP and p27KIP expression and downregulation of cyclin D1 in vitro and in vivo.Q51786739
Mouse development and cell proliferation in the absence of D-cyclins.Q52088064
P433issue60
P407language of work or nameEnglishQ1860
P921main subjectmetforminQ19484
P304page(s)101509-101519
P577publication date2017-10-06
P1433published inOncotargetQ1573155
P1476titleMetformin induces cell cycle arrest at the G1 phase through E2F8 suppression in lung cancer cells
P478volume8

Reverse relations

cites work (P2860)
Q92989938Carcinogenesis effects of E2F transcription factor 8 (E2F8) in hepatocellular carcinoma outcomes: an integrated bioinformatic report
Q59803813E2F transcription factor 8 promotes cell proliferation via CCND1/p21 in esophageal squamous cell carcinoma
Q61807404Metformin Inhibit Lung Cancer Cell Growth and Invasion in Vitro as Well as Tumor Formation in Vivo Partially by Activating PP2A
Q55153270Transcriptional E2F1/2/5/8 as potential targets and transcriptional E2F3/6/7 as new biomarkers for the prognosis of human lung carcinoma.

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