Activation of TRKA receptor elicits mastocytosis in mice and is involved in the development of resistance to KIT-targeted therapy

scientific article

Activation of TRKA receptor elicits mastocytosis in mice and is involved in the development of resistance to KIT-targeted therapy is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.18027
P932PMC publication ID5650308
P698PubMed publication ID29088753

P2093author name stringArnold Ganser
Min Yang
Michael Heuser
Guntram Büsche
Nils von Neuhoff
Felicitas Thol
Friedrich Feuerhake
Zhixiong Li
Anuhar Chaturvedi
Kezhi Huang
Zengkai Pan
Danian Nie
P2860cites workThe zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesisQ24302199
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Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice.Q35119075
Human tryptase cleaves pro-nerve growth factor (pro-NGF): hints of local, mast cell-dependent regulation of NGF/pro-NGF actionQ35213103
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Human mast cells express functional TrkA and are a source of nerve growth factor.Q41085580
Molecular profiling of myeloid progenitor cells in multi-mutated advanced systemic mastocytosis identifies KIT D816V as a distinct and late event.Q41612115
Safety and Antitumor Activity of the Multitargeted Pan-TRK, ROS1, and ALK Inhibitor Entrectinib: Combined Results from Two Phase I Trials (ALKA-372-001 and STARTRK-1).Q41636361
Oncogenic KIT-induced aggressive systemic mastocytosis requires SHP2/PTPN11 phosphatase for disease progression in miceQ41939033
Dasatinib crosses the blood-brain barrier and is an efficient therapy for central nervous system Philadelphia chromosome-positive leukemiaQ42538832
Nerve growth factor functions as a chemoattractant for mast cells through both mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathwaysQ42804693
Nerve growth factor induces apoptosis in human medulloblastoma cell lines that express TrkA receptorsQ42804769
A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinibQ44534510
Chemotherapy and dasatinib induce long-term hematologic and molecular remission in systemic mastocytosis with acute myeloid leukemia with KIT D816V.Q46262657
Resistance of mature T cells to oncogene transformationQ46357501
Gene expression profile, pathways, and transcriptional system regulation in indolent systemic mastocytosis.Q46418767
Predictable and efficient retroviral gene transfer into murine bone marrow repopulating cells using a defined vector doseQ47334460
Increased circulating levels of neurotrophins and elevated expression of their high-affinity receptors on skin and gut mast cells in mastocytosisQ47977979
Overlapping and distinct actions of the neurotrophins BDNF, NT-3, and NT-4/5 on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon.Q48196753
Allogeneic NK cells eradicate myeloblasts but not neoplastic mast cells in systemic mastocytosis associated with acute myeloid leukemia.Q48251471
Activation of TRKB receptor in murine hematopoietic stem/progenitor cells induced mastocytosisQ48603470
CD30 expression by bone marrow mast cells from different diagnostic variants of systemic mastocytosis.Q50484927
A transgenic zebrafish model expressing KIT-D816V recapitulates features of aggressive systemic mastocytosis.Q50651368
Interplay between RORgammat, Egr3, and E proteins controls proliferation in response to pre-TCR signals.Q53617339
NFκB and MAPK signalling pathways mediate TNFα-induced Early Growth Response gene transcription leading to aromatase expression.Q54444540
Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking.Q54662841
Development of a lethal mast cell disease in mice reconstituted with bone marrow cells expressing the v-erbB oncogeneQ58326964
KIT mutation in mast cells and other bone marrow hematopoietic cell lineages in systemic mast cell disorders: a prospective study of the Spanish Network on Mastocytosis (REMA) in a series of 113 patientsQ61818977
Morphologic properties of neoplastic mast cells: delineation of stages of maturation and implication for cytological grading of mastocytosisQ73936505
Murine leukemia induced by retroviral gene markingQ77975543
Remarkable leukemogenic potency and quality of a constitutively active neurotrophin receptor, deltaTrkAQ80731905
Mast Cells, Mastocytosis, and Related DisordersQ86622605
P433issue43
P407language of work or nameEnglishQ1860
P304page(s)73871-73883
P577publication date2017-05-19
P1433published inOncotargetQ1573155
P1476titleActivation of TRKA receptor elicits mastocytosis in mice and is involved in the development of resistance to KIT-targeted therapy
P478volume8

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cites work (P2860)
Q48507286Flow cytometric characterization of acute leukemia reveals a distinctive "blast gate" of murine T-lymphoblastic leukemia/lymphoma
Q90262410Revisiting NTRKs as an emerging oncogene in hematological malignancies
Q89839439The Role of Mast Cells in IgE-Independent Lung Diseases
Q92715334The transplantation of human urine stem cells combined with chondroitinase ABC promotes brain-derived neurotrophic factor and nerve growth factor following spinal cord injury in rats

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