Competition between translation initiation factor eIF5 and its mimic protein 5MP determines non-AUG initiation rate genome-wide

scientific article published on 18 September 2017

Competition between translation initiation factor eIF5 and its mimic protein 5MP determines non-AUG initiation rate genome-wide is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/NAR/GKX808
P932PMC publication ID5714202
P698PubMed publication ID28981728

P50authorIvan TopisirovicQ42738489
P2093author name stringHiroyuki Hiraishi
Yoshihiko Fujita
Chingakham Ranjit Singh
Katsura Asano
Hirohide Saito
Michael Witcher
Maud Marques
Ji Wan
Shu-Bing Qian
Christian Cox
Chelsea Moore
Abbey Anderson
Eric Aube
Jacob Morris
Jagpreet Nanda
Leiming Dong
Leiming Tang
Maika Jangal
Sarah Gillaspie
P2860cites workStringency of start codon selection modulates autoregulation of translation initiation factor eIF5Q24299338
A new translational regulator with homology to eukaryotic translation initiation factor 4GQ24532110
Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activationQ24535079
Upstream open reading frames: molecular switches in (patho)physiologyQ24614000
Functional elements in initiation factors 1, 1A, and 2β discriminate against poor AUG context and non-AUG start codonsQ24631083
Mechanisms of translational regulation by a human eIF5-mimic proteinQ24634138
Assembly and isolation of intermediate steps of transcription complexes formed on the human 5S rRNA geneQ24678227
Why is start codon selection so precise in eukaryotes?Q26827587
Translation factor control of ribosome conformation during start codon selection.Q51984242
Efficient expression and purification of human replication fork-stabilizing factor, Claspin, from mammalian cells: DNA-binding activity and novel protein interactions.Q52725097
eIF4G and CBP80 share a common origin and similar domain organization: implications for the structure and function of eIF4GQ81200643
ABC50 mutants modify translation start codon selectionQ86551172
The R3H domain stabilizes poly(A)-specific ribonuclease by stabilizing the RRM domain.Q38300120
Translational control by 5'-untranslated regions of eukaryotic mRNAsQ38867847
Upstream Open Reading Frames Differentially Regulate Gene-specific Translation in the Integrated Stress ResponseQ38881341
Translational tolerance of mitochondrial genes to metabolic energy stress involves TISU and eIF1-eIF4GI cooperation in start codon selectionQ38903731
BZW1, a novel proliferation regulator that promotes growth of salivary muocepodermoid carcinomaQ39850592
DAP5 promotes cap-independent translation of Bcl-2 and CDK1 to facilitate cell survival during mitosisQ39986438
The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation.Q41465002
Cap-proximal nucleotides via differential eIF4E binding and alternative promoter usage mediate translational response to energy stressQ42321544
Pi release from eIF2, not GTP hydrolysis, is the step controlled by start-site selection during eukaryotic translation initiationQ46772123
Reconstitution of yeast translation initiation.Q46968946
Yeast phenotypic assays on translational control.Q51976069
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factorsQ27860937
A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivoQ27876228
GTP hydrolysis controls stringent selection of the AUG start codon during translation initiation in Saccharomyces cerevisiaeQ27935355
The Mof2/Sui1 protein is a general monitor of translational accuracyQ27937473
Molecular chaperone targeting and regulation by BAG family proteinsQ28190053
The mRNA of DEAD box protein p72 is alternatively translated into an 82-kDa RNA helicaseQ28201989
Leucine-tRNA initiates at CUG start codons for protein synthesis and presentation by MHC class IQ28269864
Identification of evolutionarily conserved non-AUG-initiated N-terminal extensions in human coding sequencesQ28304019
Regulation of osteoblast development by Bcl-2-associated athanogene-1 (BAG-1)Q28830055
Essential role of eIF5-mimic protein in animal development is linked to control of ATF4 expressionQ29147399
Structural features in eukaryotic mRNAs that modulate the initiation of translationQ29547921
Ribosome profiling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomesQ29617505
The eukaryotic initiation factor (eIF) 5 HEAT domain mediates multifactor assembly and scanning with distinct interfaces to eIF1, eIF2, eIF3, and eIF4GQ34132377
Initiation context modulates autoregulation of eukaryotic translation initiation factor 1 (eIF1)Q34241370
Global mapping of translation initiation sites in mammalian cells at single-nucleotide resolutionQ34296372
Translation from unconventional 5' start sites drives tumour initiationQ34549017
Pioneer transcription factors in cell reprogrammingQ34697693
An eIF5/eIF2 complex antagonizes guanine nucleotide exchange by eIF2B during translation initiationQ35065850
Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors.Q35125960
The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2βQ36106749
Coordinated movements of eukaryotic translation initiation factors eIF1, eIF1A, and eIF5 trigger phosphate release from eIF2 in response to start codon recognition by the ribosomal preinitiation complexQ36636060
Systematic analysis of the PTEN 5' leader identifies a major AUU initiated proteoformQ36967232
β-Hairpin loop of eukaryotic initiation factor 1 (eIF1) mediates 40 S ribosome binding to regulate initiator tRNA(Met) recruitment and accuracy of AUG selection in vivoQ37189587
Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiationQ37336923
Cap-independent translation by DAP5 controls cell fate decisions in human embryonic stem cellsQ37343025
eIF1 controls multiple steps in start codon recognition during eukaryotic translation initiationQ37441324
The interaction between eukaryotic initiation factor 1A and eIF5 retains eIF1 within scanning preinitiation complexesQ37565821
Nat1 promotes translation of specific proteins that induce differentiation of mouse embryonic stem cellsQ37589973
Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5.Q37739606
The scanning mechanism of eukaryotic translation initiationQ38185457
P275copyright licenseCreative Commons Attribution-NonCommercial 4.0 InternationalQ34179348
P6216copyright statuscopyrightedQ50423863
P433issue20
P407language of work or nameEnglishQ1860
P304page(s)11941-11953
P577publication date2017-09-18
P1433published inNucleic Acids ResearchQ135122
P1476titleCompetition between translation initiation factor eIF5 and its mimic protein 5MP determines non-AUG initiation rate genome-wide
P478volume45

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cites work (P2860)
Q90157851Combinatorial modulation of initial codons for improved zeaxanthin synthetic pathway efficiency in Escherichia coli
Q58765724Comparative sequence and structure analysis of eIF1A and eIF1AD
Q61811416Comprehensive profiling of translation initiation in influenza virus infected cells
Q92875175Non-canonical translation initiation in yeast generates a cryptic pool of mitochondrial proteins
Q92594291Novel oncogene 5MP1 reprograms c-Myc translation initiation to drive malignant phenotypes in colorectal cancer
Q91691743Suppression of Ribosomal Pausing by eIF5A Is Necessary to Maintain the Fidelity of Start Codon Selection
Q92162430Translational Regulation by Upstream Open Reading Frames and Human Diseases
Q52731010Translational autoregulation of BZW1 and BZW2 expression by modulating the stringency of start codon selection.
Q99594043Unusually efficient CUG initiation of an overlapping reading frame in POLG mRNA yields novel protein POLGARF

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