Folic acid inhibits nasopharyngeal cancer cell proliferation and invasion via activation of FRα/ERK1/2/TSLC1 pathway

scientific article published on 25 October 2017

Folic acid inhibits nasopharyngeal cancer cell proliferation and invasion via activation of FRα/ERK1/2/TSLC1 pathway is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1042/BSR20170772
P932PMC publication ID5705775
P698PubMed publication ID29070520

P2093author name stringXin Jin
Shouhou Liu
Zhibiao Liu
Wen Pi
P2860cites workDown-regulation of tumor suppressor in lung cancer 1 (TSLC1) expression correlates with poor prognosis in patients with colon cancer.Q51321204
Folic acid inhibition of EGFR-mediated proliferation in human colon cancer cell linesQ73278706
High folic acid increases cell turnover and lowers differentiation and iron content in human HT29 colon cancer cellsQ81295464
Elevated physiological levels of folic acid can increase in vitro growth and invasiveness of prostate cancer cellsQ84575568
Evaluation of E-cadherin, β-catenin and vimentin protein expression using quantitative immunohistochemistry in nasopharyngeal carcinoma patientsQ85677411
Folate, vitamin B6, vitamin B12 and methionine intakes and risk for nasopharyngeal carcinoma in Chinese adults: a matched case-control studyQ86584202
Folate intake, serum folate levels, and prostate cancer risk: a meta-analysis of prospective studiesQ21257257
Patterns of regional lymph node metastasis of nasopharyngeal carcinoma: a meta-analysis of clinical evidenceQ27007474
Global cancer statistics, 2012Q27860501
Folic acid and colorectal cancer prevention: Molecular mechanisms and epidemiological evidence (Review)Q29031824
Lower serum folate is associated with development and invasiveness of gastric cancerQ34093860
Dietary folate deficiency blocks prostate cancer progression in the TRAMP model.Q35529318
Folic acid inhibits COLO-205 colon cancer cell proliferation through activating the FRα/c-SRC/ERK1/2/NFκB/TP53 pathway: in vitro and in vivo studiesQ35701974
Folate and colorectal cancer: an evidence-based critical reviewQ36734030
Retropharyngeal lymph node metastasis in nasopharyngeal carcinoma: prognostic value and staging categoriesQ36749063
Human reduced folate carrier: translation of basic biology to cancer etiology and therapyQ36749959
Prognostic factors of nasopharyngeal carcinoma: a review of 759 patientsQ38052106
Loss/Down-regulation of tumor suppressor in lung cancer 1 expression is associated with tumor progression and is a biomarker of poor prognosis in ovarian carcinomaQ38411193
Tumor suppressor in lung cancer 1 (TSLC1), a novel tumor suppressor gene, is implicated in the regulation of proliferation, invasion, cell cycle, apoptosis, and tumorigenicity in cutaneous squamous cell carcinomaQ39132912
Folate deprivation enhances invasiveness of human colon cancer cells mediated by activation of sonic hedgehog signaling through promoter hypomethylation and cross action with transcription nuclear factor-kappa B pathwayQ39372005
TSLC1 is a tumor suppressor gene associated with metastasis in nasopharyngeal carcinomaQ40224137
Tumor Suppressor in Lung Cancer-1 Is a Prognostic Predictor for the Recurrence and Progression of Non-Muscle-Invasive Bladder CancerQ40900040
Folate stimulates ERK1/2 phosphorylation and cell proliferation in fetal neural stem cellsQ43275295
Tumor suppressor TSLC1 is implicated in cell proliferation, invasion and apoptosis in laryngeal squamous cell carcinoma by regulating Akt signaling pathwayQ46208226
Folic acid inhibits endothelial cell proliferation through activating the cSrc/ERK 2/NF-κB/p53 pathway mediated by folic acid receptorQ46354780
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P921main subjectfolic acidQ127060
P577publication date2017-10-25
P1433published inBioscience ReportsQ2790714
P1476titleFolic acid inhibits nasopharyngeal cancer cell proliferation and invasion via activation of FRα/ERK1/2/TSLC1 pathway
P478volume37

Reverse relations

cites work (P2860)
Q58802900Functionalized Folic Acid-Conjugated Amphiphilic Alternating Copolymer Actively Targets 3D Multicellular Tumour Spheroids and Delivers the Hydrophobic Drug to the Inner Core
Q92717803Tripartite Motif Containing 11 Interacts with DUSP6 to Promote the Growth of Human Osteosarcoma Cells through Regulating ERK1/2 Pathway

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