Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass.

scientific article published on 12 October 2017

Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1126/SCIENCE.AAM9305
P932PMC publication ID5748897
P698PubMed publication ID29025995

P50authorClary B ClishQ56988961
Haejin YoonQ82795641
Marcia C. HaigisQ89295268
Alison E RingelQ89620587
P2093author name stringJessica B Spinelli
Sarah Jeanfavre
P2860cites workIdentification of small molecule inhibitors of pyruvate kinase M2Q22001512
Glutamine synthetase is essential for proliferation of fetal skin fibroblastsQ24318220
Understanding the Warburg effect: the metabolic requirements of cell proliferationQ24604760
Function of human Rh based on structure of RhCG at 2.1 AQ24606200
Proline metabolism and cancer: emerging links to glutamine and collagenQ26861005
Regulation of enzymes of the urea cycle and arginine metabolismQ28203558
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesisQ29617613
Ammonia toxicity to the brainQ30575263
Growth-limiting intracellular metabolites in yeast growing under diverse nutrient limitationsQ33571626
Q's next: the diverse functions of glutamine in metabolism, cell biology and cancerQ33604129
From Krebs to clinic: glutamine metabolism to cancer therapy.Q33834498
Analysis of apoptosis by propidium iodide staining and flow cytometryQ34615421
Nitrogen anabolism underlies the importance of glutaminolysis in proliferating cellsQ34619590
Stable isotope-resolved metabolomics (SIRM) in cancer research with clinical application to nonsmall cell lung cancerQ35075007
Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growthQ35075942
Npr2 inhibits TORC1 to prevent inappropriate utilization of glutamine for biosynthesis of nitrogen-containing metabolitesQ35592800
An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate SynthesisQ35908707
Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma.Q36330223
The Emerging Hallmarks of Cancer MetabolismQ36468964
Proteomic maps of breast cancer subtypesQ36499111
Tissue specificity of mitochondrial glutamate pathways and the control of metabolic homeostasisQ37166540
Hepatic glutamate metabolism: a tale of 2 hepatocytesQ37559039
On the reversibility of glutamate dehydrogenase and the source of hyperammonemia in the hyperinsulinism/hyperammonemia syndromeQ37628852
Ammonium metabolism in humansQ38037936
Refining the ammonia hypothesis: a physiology-driven approach to the treatment of hepatic encephalopathyQ38417282
Proline Starvation Induces Unresolved ER Stress and Hinders mTORC1-Dependent TumorigenesisQ38746785
CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cellsQ38766859
Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells.Q38847446
Ammonia toxicity: from head to toe?Q39052232
A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasiaQ39156501
The effect of pH and ADP on ammonia affinity for human glutamate dehydrogenases.Q39192284
Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES)Q39253539
Normoxic accumulation of HIF1α is associated with glutaminolysisQ39938298
Ammonium-induced calcium mobilization in 1321N1 astrocytoma cellsQ40039083
An LC-MS Approach to Quantitative Measurement of Ammonia IsotopologuesQ41606937
Ammonia derived from glutaminolysis is a diffusible regulator of autophagyQ42470786
Isolation of interstitial fluid from rat mammary tumors by a centrifugation methodQ44185674
Intramitochondrial localization of alanine aminotransferase in rat-liver mitochondria: comparison with glutaminase and aspartate aminotransferaseQ46455614
Methods for long-term 17β-estradiol administration to mice.Q51380225
Mitochondria and Cancer.Q53198693
Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells.Q54197272
P433issue6365
P407language of work or nameEnglishQ1860
P921main subjectammoniaQ4087
biomassQ2945560
P304page(s)941-946
P577publication date2017-10-12
P1433published inScienceQ192864
P1476titleMetabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass
P478volume358

Reverse relations

cites work (P2860)
Q58692000A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3
Q100443903A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer
Q64119394Acid-Induced Downregulation of ASS1 Contributes to the Maintenance of Intracellular pH in Cancer
Q100455053Allosteric regulation of glutamate dehydrogenase deamination activity
Q91656807Cancer Metabolism Drives a Stromal Regenerative Response
Q89998327Cancer-associated adipocytes: key players in breast cancer progression
Q88377569Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells
Q89976198Carbohydrate and Amino Acid Metabolism as Hallmarks for Innate Immune Cell Activation and Function
Q92471718Circadian Clocks and Cancer: Timekeeping Governs Cellular Metabolism
Q90568501Comprehensive Metabolomic Search for Biomarkers to Differentiate Early Stage Hepatocellular Carcinoma from Cirrhosis
Q60909437Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia
Q94672643Distinct pattern of one-carbon metabolism, a nutrient-sensitive pathway, in invasive breast cancer: A metabolomic study
Q47224379Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism.
Q91942058Esculetin Inhibits Cancer Cell Glycolysis by Binding Tumor PGK2, GPD2, and GPI
Q87963898Expanding the Coverage of the Metabolome with Nitrogen-Based NMR
Q49952078Feeding frenzy for cancer cells
Q49798196Glutamine Synthetase: Localization Dictates Outcome
Q97643295Identifying strategies to target the metabolic flexibility of tumours
Q57823454Impact of Gender and Age on Hyperthermia-Induced Changes in Respiration of Liver Mitochondria
Q54945775Influence of the Tumor Microenvironment on Cancer Cells Metabolic Reprogramming.
Q55668835Integrated omics and gene expression analysis identifies the loss of metabolite–metabolite correlations in small cell lung cancer.
Q89250631Localization of Human Glutamate Dehydrogenases Provides Insights into Their Metabolic Role and Their Involvement in Disease Processes
Q64245167Metabolic Reprogramming in Breast Cancer and Its Therapeutic Implications
Q92023481Metabolic interventions in the immune response to cancer
Q91974693Metabolic reprogramming in triple-negative breast cancer
Q61817998Metformin Impairs Glutamine Metabolism and Autophagy in Tumour Cells
Q90715129Microbiota facilitates the formation of the aminated metabolite of green tea polyphenol (-)-epigallocatechin-3-gallate which trap deleterious reactive endogenous metabolites
Q58796751Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies
Q48247976Mitochondrial DNA, nuclear context, and the risk for carcinogenesis
Q100490619NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications
Q91826282New aspects of amino acid metabolism in cancer
Q58747689Nitrogen isotope signature evidences ammonium deprotonation as a common transport mechanism for the AMT-Mep-Rh protein superfamily
Q99616842Ornithine and breast cancer: a matched case-control study
Q89167709Peptidylarginine deiminase 4: a nuclear button triggering neutrophil extracellular traps in inflammatory diseases and aging
Q93200202Physiological Role of Glutamate Dehydrogenase in Cancer Cells
Q52707854Polymer Therapeutics: Biomarkers and New Approaches for Personalized Cancer Treatment.
Q91336188Rewiring urea cycle metabolism in cancer to support anabolism
Q64061728Submergence and Waterlogging Stress in Plants: A Review Highlighting Research Opportunities and Understudied Aspects
Q91451109Targeting LIN28B reprograms tumor glucose metabolism and acidic microenvironment to suppress cancer stemness and metastasis
Q92573701Targeting extracellular nutrient dependencies of cancer cells
Q60914167The Adaptive Complexity of Cancer
Q64971598The Diverse Functions of Non-Essential Amino Acids in Cancer.
Q64885009The Fate of Glutamine in Human Metabolism. The Interplay with Glucose in Proliferating Cells.
Q92543544The Pleiotropic Effects of Glutamine Metabolism in Cancer
Q52592104The Proline Cycle As a Potential Cancer Therapy Target.
Q92642235The Tumor Microenvironment in Colorectal Cancer Therapy
Q61798997The ability to utilise ammonia as nitrogen source is cell type specific and intricately linked to GDH, AMPK and mTORC1
Q64969261The emerging link between cancer, metabolism, and circadian rhythms.
Q64963377The multifaceted contributions of mitochondria to cellular metabolism.
Q64122915Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures
Q91886008Warburg Effects in Cancer and Normal Proliferating Cells: Two Tales of the Same Name
Q89759234Yeast filamentation signaling is connected to a specific substrate translocation mechanism of the Mep2 transceptor
Q90348636Zeta-crystallin: a moonlighting player in cancer
Q64935902p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis.

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