Aging, Obesity, and Inflammatory Age-Related Diseases

scientific article published on 7 December 2017

Aging, Obesity, and Inflammatory Age-Related Diseases is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.3389/FIMMU.2017.01745
P932PMC publication ID5725402
P698PubMed publication ID29270179

P2093author name stringBonnie B Blomberg
Daniela Frasca
Roberto Paganelli
P2860cites workInflammation and insulin resistanceQ22241893
A novel transcription factor, T-bet, directs Th1 lineage commitmentQ22253874
B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodiesQ24598772
Global prevalence of dementia: a Delphi consensus studyQ24603249
Mechanisms underlying the resistance to diet-induced obesity in germ-free miceQ24676006
Communicable ulcerative colitis induced by T-bet deficiency in the innate immune systemQ24680733
Ageing, autoimmunity and arthritis: Perturbations of TCR signal transduction pathways with ageing - a biochemical paradigm for the ageing immune systemQ24795134
Cross-presentation of IgG-containing immune complexesQ26825801
T-cell aging in rheumatoid arthritisQ26859971
Adipose tissue as an immunological organQ27003461
Obesity is associated with macrophage accumulation in adipose tissueQ27860976
Microbial ecology: human gut microbes associated with obesityQ27861004
The Obesity Epidemic and Consequences for Rheumatoid Arthritis CareQ28074864
Biochemistry and molecular cell biology of diabetic complicationsQ28131781
Central obesity and increased risk of dementia more than three decades laterQ28274012
Cytokines in the pathogenesis of rheumatoid arthritisQ28303865
Obesity induces a phenotypic switch in adipose tissue macrophage polarizationQ29547686
Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signalingQ29616024
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesityQ29617380
Obesity and dementia: adipokines interact with the brain.Q30361051
Healthy ageing in 2016: Obesity in geroscience - is cellular senescence the culprit?Q52931529
B cell resistance to Fas-mediated apoptosis contributes to their ineffective control by regulatory T cells in rheumatoid arthritis.Q53082574
Overweight decreases the chance of achieving good response and low disease activity in early rheumatoid arthritisQ57224067
Rheumatoid cachexia: depletion of lean body mass in rheumatoid arthritis. Possible association with tumor necrosis factorQ67965278
Distinct functions of interferon-gamma for chemokine expression in models of acute lung inflammationQ77807412
IFN-gamma-inducible chemokines enhance adaptive immunity and colitisQ79222482
Prevalence of the metabolic syndrome is increased in rheumatoid arthritis and is associated with coronary atherosclerosisQ79698753
Rheumatic disease in the elderly: rheumatoid arthritisQ79970298
Aging, obesity, and multimorbidity in women 50 years or older: a population-based studyQ86524651
Rheumatoid arthritis: Obesity impairs efficacy of anti-TNF therapy in patients with RAQ87370747
Tight control of disease activity fails to improve body composition or physical function in rheumatoid arthritis patientsQ87640574
Obesity in rheumatoid arthritisQ37801496
What's new in our understanding of the role of adipokines in rheumatic diseases?Q37909903
A role for the NLRP3 inflammasome in metabolic diseases--did Warburg miss inflammation?Q37995073
A ceramide-centric view of insulin resistanceQ38007631
The influence of ageing on the development and management of rheumatoid arthritisQ38115131
Rheumatoid arthritis and metabolic syndromeQ38236740
The impact of biological therapy on regulatory T cells in rheumatoid arthritisQ38350483
Lipid and Metabolic Changes in Rheumatoid Arthritis.Q38554197
Aging and age related stresses: a senescence mechanism of intervertebral disc degenerationQ38604311
Association of Body Mass Index Categories with Disease Activity and Radiographic Joint Damage in Rheumatoid Arthritis: A Systematic Review and MetaanalysisQ38622041
Impact of obesity on the clinical outcome of rheumatologic patients in biotherapyQ38710721
Biomolecular features of inflammation in obese rheumatoid arthritis patients: management considerationsQ38763702
Impact of Obesity on Remission and Disease Activity in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.Q38829639
Vital Signs: Prevalence of Doctor-Diagnosed Arthritis and Arthritis-Attributable Activity Limitation - United States, 2013-2015.Q38917607
Sarcopenic obesity or obese sarcopenia: A cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the pathogenesisQ38972188
Cellular aging towards osteoarthritisQ39065937
Human peripheral late/exhausted memory B cells express a senescent-associated secretory phenotype and preferentially utilize metabolic signaling pathwaysQ39118824
The Effect of Aging and Mechanical Loading on the Metabolism of Articular CartilageQ39156880
Immunometabolism in early and late stages of rheumatoid arthritis.Q39209693
Obesity Trends Among US Adults With Doctor-Diagnosed Arthritis 2009-2014.Q39663234
Associations between body mass, radiographic joint damage, adipokines and risk factors for bone loss in rheumatoid arthritisQ39710835
Aging phenomena and osteoarthritis: cause or coincidence? Claude P. Brown memorial lecture.Q39753934
Body mass index in midlife and dementia: Systematic review and meta-regression analysis of 589,649 men and women followed in longitudinal studiesQ40100137
Modifiable Risk Factors for Prevention of Dementia in Midlife, Late Life and the Oldest-Old: Validation of the LIBRA IndexQ40223283
The metabolic profile in early rheumatoid arthritis: a high prevalence of metabolic obesityQ40797292
The Role of Aging in the Development of OsteoarthritisQ41112232
Rheumatoid arthritis: Debunking the obesity-mortality paradox in RA.Q41120020
Obesity induces pro-inflammatory B cells and impairs B cell function in old miceQ41445678
Aging and osteoarthritisQ42011299
Chronic TNFalpha and cAMP pre-treatment of human adipocytes alter HSL, ATGL and perilipin to regulate basal and stimulated lipolysisQ42458765
Mammalian target of rapamycin signaling is crucial for joint destruction in experimental arthritis and is activated in osteoclasts from patients with rheumatoid arthritisQ43053164
Rheumatoid cachexia: a complication of rheumatoid arthritis moves into the 21st centuryQ43120866
Effect of body mass index on mortality and clinical status in rheumatoid arthritisQ45158519
Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer diseaseQ46745854
Low body mass index is associated with impaired quality of life in patients with rheumatoid arthritisQ47687959
Regulation of immunity and inflammation by hypoxia in immunological nichesQ47708732
Aging and osteoarthritis: Central role of the extracellular matrix.Q47836823
The path from obesity and hypertension to dementiaQ48449967
Body mass does not impact the clinical response to intravenous abatacept in patients with rheumatoid arthritis. Analysis from the "pan-European registry collaboration for abatacept (PANABA).Q51013068
Adipose Tissue Macrophages in Rheumatoid Arthritis: Prevalence, Disease-Related Indicators, and Associations With Cardiometabolic Risk Factors.Q51067097
Arthritis-specific health beliefs related to aging among older male patients with knee and/or hip osteoarthritis.Q51906248
Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity.Q52902953
Health Effects of Overweight and Obesity in 195 Countries over 25 YearsQ30402965
Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway.Q33553780
Cellular senescence in aging and osteoarthritisQ33557205
Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factorsQ33814389
Inflammatory networks during cellular senescence: causes and consequencesQ33889156
Global epidemiology of dementia: Alzheimer's and vascular typesQ33893789
Sarcopenia: a major modifiable cause of frailty in the elderlyQ33998731
The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipaseQ34216687
MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodelling.Q34280968
The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cellsQ34310345
Spleen supports a pool of innate-like B cells in white adipose tissue that protects against obesity-associated insulin resistanceQ34442154
Adipokines: a link between obesity and dementia?Q34496620
Osteoarthritis, obesity and weight loss: evidence, hypotheses and horizons - a scoping review.Q34548275
Inflammation, metaflammation and immunometabolic disordersQ34550852
Autoantibodies in rheumatoid arthritis and their clinical significanceQ34731269
Normalization of obesity-associated insulin resistance through immunotherapyQ34994222
Role of gut microbiota in obesity, type 2 diabetes and Alzheimer's diseaseQ34995338
Adipose tissue dendritic cells enhances inflammation by prompting the generation of Th17 cellsQ35124175
Hypoxia-inducible factors as essential regulators of inflammationQ35130618
Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-gamma in inflammation in human adipose tissueQ35147250
Immunosenescence, autoimmunity, and rheumatoid arthritisQ35198258
Tumor necrosis factor alpha inhibits signaling from the insulin receptorQ35304189
Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.Q35404457
Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesityQ35578618
Expansion of Activated Peripheral Blood Memory B Cells in Rheumatoid Arthritis, Impact of B Cell Depletion Therapy, and Biomarkers of ResponseQ35654669
Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesityQ35660131
Association between body composition and disease activity in rheumatoid arthritis. A systematic reviewQ35835492
Rheumatoid cachexia: metabolic abnormalities, mechanisms and interventions.Q35855164
Aging theories of primary osteoarthritis: from epidemiology to molecular biology.Q35863454
Inflammation-induced formation of fat-associated lymphoid clustersQ35882546
The risk of overweight/obesity in mid-life and late life for the development of dementia: a systematic review and meta-analysis of longitudinal studiesQ35893532
Five stages of evolving beta-cell dysfunction during progression to diabetesQ35961960
The challenging interplay between rheumatoid arthritis, ageing and comorbiditiesQ36000249
Aging and osteoarthritis: an inevitable encounter?Q36036777
Arthritis and aging.Q36089611
Body mass index and the rheumatoid arthritis swollen joint count: an observational studyQ36198718
Inflammaging decreases adaptive and innate immune responses in mice and humansQ36225887
Body mass index influences the response to infliximab in ankylosing spondylitisQ36245977
Systemic inflammation and insulin sensitivity in obese IFN-γ knockout miceQ36278695
Metabolic syndrome and its components among rheumatoid arthritis patients: A comprehensive updated systematic review and meta-analysisQ36319729
The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's diseaseQ36370178
Midlife and late-life obesity and the risk of dementia: cardiovascular health studyQ36441882
Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes.Q36477239
Antigen- and cytokine-driven accumulation of regulatory T cells in visceral adipose tissue of lean miceQ36561831
Importance of TNFalpha and neutral lipases in human adipose tissue lipolysisQ36580027
Anti-tumour necrosis factor alpha therapy improves insulin sensitivity in normal-weight but not in obese patients with rheumatoid arthritis.Q36633289
Therapeutic B cell depletion impairs adaptive and autoreactive CD4+ T cell activation in miceQ36693339
B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profileQ36729660
Weight Loss, the Obesity Paradox, and the Risk of Death in Rheumatoid ArthritisQ36784192
Insulin sensitivity: modulation by nutrients and inflammationQ36848937
The Epidemiology of Obesity: A Big PictureQ36877310
Adipose Tissue Hypoxia, Inflammation, and Fibrosis in Obese Insulin-Sensitive and Obese Insulin-Resistant SubjectsQ36935513
Improved insulin sensitivity despite increased visceral adiposity in mice deficient for the immune cell transcription factor T-betQ36938197
Aging processes and the development of osteoarthritisQ37019846
Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic responseQ37105363
Production of RANKL by Memory B Cells: A Link Between B Cells and Bone Erosion in Rheumatoid ArthritisQ37115802
Rheumatoid cachexia: a clinical perspectiveQ37151582
Abnormal body composition phenotypes in older rheumatoid arthritis patients: association with disease characteristics and pharmacotherapiesQ37163337
Association of epicardial adipose tissue with cardiometabolic risk and metabolic syndrome in patients with rheumatoid arthritisQ37179297
Anti-cyclic citrullinated peptide antibody is a good indicator for the diagnosis of rheumatoid arthritisQ37258094
Killer Cell Lectin-like Receptor G1 Inhibits NK Cell Function through Activation of Adenosine 5'-Monophosphate-Activated Protein KinaseQ37265371
Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritisQ37357112
Rheumatic diseases and obesity: adipocytokines as potential comorbidity biomarkers for cardiovascular diseasesQ37385755
A Comparison of the Prevalence of Dementia in the United States in 2000 and 2012.Q37541463
Rejuvenating the immune system in rheumatoid arthritisQ37607081
Th17 and CD24hiCD27+ regulatory B lymphocytes are biomarkers of response to biologics in rheumatoid arthritisQ37635190
Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype.Q37635856
P921main subjectobesityQ12174
P304page(s)1745
P577publication date2017-12-07
P1433published inFrontiers in ImmunologyQ27723748
P1476titleAging, Obesity, and Inflammatory Age-Related Diseases
P478volume8

Reverse relations

cites work (P2860)
Q90004224A Systematic Review and Meta-analysis of Environmental, Lifestyle, and Health Factors Associated With DNA Methylation Age
Q64085536Age-Associated Changes in the Immune System and Blood⁻Brain Barrier Functions
Q91890102Aging and the clock: Perspective from flies to humans
Q64116474Association between osteoarthritis and increased risk of dementia: A systemic review and meta-analysis
Q89484942CSF1R inhibitor PLX5622 and environmental enrichment additively improve metabolic outcomes in middle-aged female mice
Q91736673Chronic inflammation in the etiology of disease across the life span
Q89282120Effect of glucosamine and chondroitin sulfate in symptomatic knee osteoarthritis: a systematic review and meta-analysis of randomized placebo-controlled trials
Q64230066Emerging roles of long noncoding RNA in chondrogenesis, osteogenesis, and osteoarthritis
Q92663882Epigenetic Signaling and RNA Regulation in Cardiovascular Diseases
Q89574891Exploratory examination of inflammation state, immune response and blood cell composition in a human obese cohort to identify potential markers predicting cancer risk
Q54181444Glycogen synthase kinase 3β helps heart to pump better in obese patients.
Q90401365Health Challenges of the Pacific Region: Insights From History, Geography, Social Determinants, Genetics, and the Microbiome
Q64106858Health and Disease-Emergent States Resulting From Adaptive Social and Biological Network Interactions
Q92688301Histologic analysis and lipid profiling reveal reproductive age-associated changes in peri-ovarian adipose tissue
Q99722612Hypothalamic neurogenesis and its implications for obesity-induced anxiety disorders
Q89505164In vivo protective effect of adipsin-deficiency on spontaneous knee osteoarthritis in aging mice
Q91045605Inflammation Mediates Body Weight and Ageing Effects on Psychomotor Slowing
Q64257625Influence of Obesity on Pneumococcus Infection Risk in the Elderly
Q91956664Influence of Weight Reduction and Enhanced Protein Intake on Biomarkers of Inflammation in Older Adults with Obesity
Q99635815Localized cytokine responses to total knee arthroplasty and total knee revision complications
Q89878396Molecular Mechanisms Contributing to Mesenchymal Stromal Cell Aging
Q90212537Obesity and CD8 T cell metabolism: Implications for anti-tumor immunity and cancer immunotherapy outcomes
Q96690341Obesity and diabetes as high-risk factors for severe coronavirus disease 2019 (COVID-19)
Q64063496Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis
Q59809211Omega-9 Oleic Acid, the Main Compound of Olive Oil, Mitigates Inflammation during Experimental Sepsis
Q55022891Sarcopenia: assessment of disease burden and strategies to improve outcomes.
Q55075666Sex Differences in Adipose Tissue CD8+ T Cells and Regulatory T Cells in Middle-Aged Mice.
Q92178204TRPV1 Antagonists as Novel Anti-Diabetic Agents: Regulation of Oral Glucose Tolerance and Insulin Secretion Through Reduction of Low-Grade Inflammation?
Q89623629The Association Between Body Mass Index and Comorbidity, Quality of Life, and Cognitive Function in the Elderly Population
Q90641648The Effects of Obesity on Outcome in Preclinical Animal Models of Infection and Sepsis: A Systematic Review and Meta-Analysis
Q55283292The Mediating Role of Overweight and Obesity in the Prospective Association between Overall Dietary Quality and Healthy Aging.
Q90446732The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Aging: Implications in Obesity and Cardiovascular Disease
Q91937333The clock is ticking: the impact of ageing on T cell metabolism
Q60934870The impact of senescence-associated T cells on immunosenescence and age-related disorders

Search more.