Interleukin-6 in Schizophrenia-Is There a Therapeutic Relevance?

scientific article published on 6 November 2017

Interleukin-6 in Schizophrenia-Is There a Therapeutic Relevance? is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3389/FPSYT.2017.00221
P932PMC publication ID5681495
P698PubMed publication ID29163240

P50authorNebojsa ArsenijevicQ47155565
Ivan P JovanovicQ56997852
Milica Milovan BorovcaninQ47155558
Jelena PanticQ47155562
Gordana RadosavljevicQ47155564
P2093author name stringMiodrag L Lukic
Slavica Minic Janicijevic
P2860cites workSerum cytokine concentrations in patients with schizophreniaQ71506011
Plasma levels of interleukin-1 beta and interleukin-6 in schizophrenia, other psychoses, and affective disordersQ72031563
Serum interleukin-6 concentration in schizophrenia: elevation associated with duration of illnessQ72679203
Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55Q72690586
Elevated interleukin-6 in schizophreniaQ73222786
Elevated interleukin-6 in the cerebrospinal fluid of a previously delineated schizophrenia subtypeQ73509362
Interleukin-6 levels in the central nervous system are negatively correlated with fat mass in overweight/obese subjectsQ73933538
Relationships between interleukins, neurotransmitters and psychopathology in drug-free male schizophrenicsQ74233692
Impaired glucose tolerance in first-episode drug-naïve patients with schizophreniaQ80024902
The facts of schizophrenia: a personal commentaryQ83766661
Decreased serum levels of interleukin-2 and interleukin-6 in Indian Bengalee schizophrenic patientsQ84013033
Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistanceQ84707922
Ingested (oral) tocilizumab inhibits EAEQ87915233
Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman diseaseQ34431511
Psychoneuroimmunology or immunopsychiatry?Q34493614
Gastrointestinal inflammation and associated immune activation in schizophrenia.Q34574957
Inhibitory effects of aripiprazole on interferon-gamma-induced microglial activation via intracellular Ca2+ regulation in vitro.Q34590921
Gut microbiome, obesity, and metabolic dysfunctionQ34629745
TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathologyQ34712326
Metabolic and inflammatory genes in schizophreniaQ34769260
Regulation of interleukin-6 and leptin in schizophrenia patients: a preliminary analysisQ34942662
The two faces of IL-6 on Th1/Th2 differentiationQ34996767
IL-6 mediates the susceptibility of glycoprotein 130 hypermorphs to Toxoplasma gondiiQ35058854
Increased levels of IL-6 in the cerebrospinal fluid of patients with chronic schizophrenia--significance for activation of the kynurenine pathway.Q35162796
Genomics of schizophrenia: time to consider the gut microbiome?Q35307203
Lymphocytes as a neural probe: potential for studying psychiatric disordersQ35749575
Cortisol and Inflammatory Biomarkers Predict Poor Treatment Response in First Episode PsychosisQ35950801
Interleukin-6: the missing element of the neurocognitive deterioration in schizophrenia? The focus on genetic underpinnings, cognitive impairment and clinical manifestation.Q35968008
The value of interleukin 6 as a peripheral diagnostic marker in schizophreniaQ36024597
Association of serum interleukin 6 and C-reactive protein in childhood with depression and psychosis in young adult life: a population-based longitudinal studyQ36032535
Rapid linkage of innate immunological signals to adaptive immunity by the brain-fat axisQ36041841
Childhood trauma and adulthood inflammation: a meta-analysis of peripheral C-reactive protein, interleukin-6 and tumour necrosis factor-α.Q36045153
Stromal-derived IL-6 alters the balance of myeloerythroid progenitors during Toxoplasma gondii infectionQ36055984
Is there a role for immune-to-brain communication in schizophrenia?Q36351021
Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cellsQ36376543
Innate immunity gone awry: linking microbial infections to chronic inflammation and cancerQ36404654
The microbiome-gut-brain axis: implications for schizophrenia and antipsychotic induced weight gain.Q36408212
Increased serum interleukin-1beta and interleukin-6 in elderly, chronic schizophrenic patients on stable antipsychotic medicationQ36700322
Inflammatory cytokine alterations in schizophrenia: a systematic quantitative reviewQ37001984
Impact of atypical antipsychotic therapy on leptin, ghrelin, and adiponectinQ37060706
Adjunctive use of nonsteroidal anti-inflammatory drugs for schizophrenia: a meta-analytic investigation of randomized controlled trialsQ37228346
Cultured sympathetic neurons synthesize and release the cytokine interleukin 1 betaQ37280573
The influence of leptin on the dopamine system and implications for ingestive behavior.Q37520621
Cytokines and schizophrenia: Microglia hypothesis of schizophrenia.Q37541981
Interleukin-6 signaling drives fibrosis in unresolved inflammationQ37572817
Development of DSM-V and ICD-11: tendencies and potential of new classifications in psychiatry at the current state of knowledgeQ37605220
Epidemiology-driven neurodevelopmental animal models of schizophrenia.Q37621632
Novel immunosuppressive properties of interleukin-6 in dendritic cells: inhibition of NF-kappaB binding activity and CCR7 expressionQ47215845
The inflammatory response system in treatment-resistant schizophrenia: increased serum interleukin-6.Q47741981
The expressions of mRNAs for interleukin-6 (IL-6) and the IL-6 receptor (IL-6R) in the rat hypothalamus and midbrain during restraint stressQ47893353
Effects of clozapine on in vitro immune parameters: a longitudinal study in clozapine-treated schizophrenic patientsQ47965814
A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depressionQ48063321
Interleukin-1 immunoreactive innervation of the human hypothalamusQ48088092
Cytokine-specific central monoamine alterations induced by interleukin-1, -2 and -6.Q48139231
Plasma and cerebrospinal fluid interleukin-1 beta and interleukin-6 in hospitalized schizophrenic patients.Q48220306
Effects of olanzapine on the elevation of macrophage infiltration and pro-inflammatory cytokine expression in female ratsQ48478301
Effects of pro-inflammatory cytokines and chemokines on leptin production in human adipose tissue in vitro.Q48612749
Regulatory T cells suppress sickness behaviour development without altering liver injury in cholestatic miceQ48821129
Tumor necrosis factor-alpha and interleukin-6 regulate secretion of brain-derived neurotrophic factor in human monocytesQ49049474
Increased serum interleukin-6 levels in early stages of psychosis: associations with at-risk mental states and the severity of psychotic symptoms.Q50661690
Elevated serum level of type-2 cytokine and low IL-17 in first episode psychosis and schizophrenia in relapse.Q50743494
Nonsteroidal anti-inflammatory drugs in schizophrenia: ready for practice or a good start? A meta-analysis.Q50773766
Interleukin-6 and the granulocyte colony-stimulating factor receptor are major independent regulators of granulopoiesis in vivo but are not required for lineage commitment or terminal differentiation.Q51100774
Increased tumor necrosis factor-alpha concentrations with interleukin-4 concentrations in exacerbations of schizophrenia.Q51887161
Plasma levels of cytokines and soluble cytokine receptors in psychiatric patients upon hospital admission: effects of confounding factors and diagnosis.Q51981236
Soluble factor(s) from LPS-activated macrophages induce cytotoxic T cell differentiation from alloantigen-primed spleen cells.Q52228983
Antipsychotic treatment may alter T-helper (TH) 2 arm cytokines.Q53602998
Lipid profile disturbances in antipsychotic-naive patients with first-episode non-affective psychosis: Authors' reply.Q53759693
In vivo immunomodulatory effects of clozapine in schizophreniaQ56767408
Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10Q56930023
Schizophrenia patients with a history of childhood trauma have a pro-inflammatory phenotypeQ57513593
Cytokine profiles in drug-naive schizophrenic patientsQ57997579
Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasisQ59326208
Intracerebroventricular interleukin-6 treatment decreases body fat in ratsQ59649473
Interleukin-6 Regulates Human Adipose Tissue Lipid Metabolism and Leptin Productionin VitroQ60632247
Cutting Edge: Trans-Signaling via the Soluble IL-6R Abrogates the Induction of FoxP3 in Naive CD4+CD25- T CellsQ62658842
Family history of type 2 diabetes in schizophrenic patientsQ69367752
Interleukin-6 improves the survival of mesencephalic catecholaminergic and septal cholinergic neurons from postnatal, two-week-old rats in culturesQ70147597
Cortical grey matter volume reduction in people with schizophrenia is associated with neuro-inflammationQ37622623
IL-6: regulator of Treg/Th17 balanceQ37768101
Anti-inflammatory signaling in schizophreniaQ37888032
Immunological treatment options for schizophreniaQ37979288
The cellular and signaling networks linking the immune system and metabolism in diseaseQ37991199
Interleukin-6, a major cytokine in the central nervous systemQ38058511
Neuroprotective effects of leptin in the context of obesity and metabolic disordersQ38208135
Interleukin-6 as a therapeutic targetQ38318758
Transforming growth factor-beta enhances and pro-inflammatory cytokines inhibit ob gene expression in 3T3-L1 adipocytesQ38341634
IL-6 as a keystone cytokine in health and diseaseQ38433045
Meta-analysis of glucose tolerance, insulin, and insulin resistance in antipsychotic-naïve patients with nonaffective psychosisQ38981510
Inflammation in Schizophrenia: Cytokine Levels and Their Relationships to Demographic and Clinical VariablesQ39166258
Factor analysis of risk variables associated with low-grade inflammationQ40127876
Innate inhibition of adaptive immunity: Mycobacterium tuberculosis-induced IL-6 inhibits macrophage responses to IFN-gammaQ40624612
Role of interleukin 6 in fever in ratsQ40764333
Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) geneQ41349604
T-cell recruitment and Th1 polarization in adipose tissue during diet-induced obesity in C57BL/6 miceQ41560139
Immune-inflammatory markers in schizophrenia: comparison to normal controls and effects of clozapineQ42283978
Th1, Th2 and Th3 cytokine alteration in schizophreniaQ42472093
Increased levels of circulating insulin-related peptides in first-onset, antipsychotic naïve schizophrenia patientsQ43185085
Natural killer T cells are involved in adipose tissues inflammation and glucose intolerance in diet-induced obese miceQ43243138
Interleukin-6-deficient mice develop mature-onset obesityQ43851625
Noradrenaline acting on astrocytic β₂-adrenoceptors induces neurite outgrowth in primary cortical neuronsQ44524644
The effects of atypical antipsychotics on visceral fat distribution in first episode, drug-naive patients with schizophreniaQ44766600
Clinical effects of COX-2 inhibitors on cognition in schizophrenia.Q45153924
Antipsychotics can modulate the cytokine profile in schizophrenia: attenuation of the type-2 inflammatory responseQ45169191
Components of the interleukin-6 transsignalling system are associated with the metabolic syndrome, endothelial dysfunction and arterial stiffnessQ45197223
Differential correlations between inflammatory cytokines and psychopathology in veterans with schizophrenia: potential role for IL-17 pathwayQ45329206
Cytokine and adipokine alterations in patients with schizophrenia treated with clozapineQ45372399
Interleukin-1 beta and tumor necrosis factor-alpha synergistically stimulate nerve growth factor (NGF) release from cultured rat astrocytesQ46167645
Molecular cloning and expression of an IL-6 signal transducer, gp130Q24328945
Viruses, schizophrenia, and bipolar disorderQ24669648
Inflammation and immunity in schizophrenia: implications for pathophysiology and treatmentQ26781620
Cytokine hypothesis of schizophrenia pathogenesis: evidence from human studies and animal modelsQ27687241
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cellsQ27860460
Obesity is associated with macrophage accumulation in adipose tissueQ27860976
Transforming growth factor-beta induces development of the T(H)17 lineageQ28237370
Putative neuroprotective agents in neuropsychiatric disordersQ28279830
Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptorQ28291157
The antipsychotic spiperone attenuates inflammatory response in cultured microglia via the reduction of proinflammatory cytokine expression and nitric oxide productionQ28293593
Serum IL-1beta, sIL-2R, IL-6, IL-8 and TNF-alpha in schizophrenic patients, relation with symptomatology and responsiveness to risperidone treatmentQ28350052
Metabolic consequences of interleukin-6 challenge in developing neurons and astrogliaQ28397737
Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effectsQ28657600
Obesity induces a phenotypic switch in adipose tissue macrophage polarizationQ29547686
Protection from obesity-induced insulin resistance in mice lacking TNF-alpha functionQ29616104
Type 2 diabetes as an inflammatory diseaseQ29617184
Immune system and glucose metabolism interaction in schizophrenia: a chicken-egg dilemmaQ30574207
Dysregulation of chemo-cytokine production in schizophrenic patients versus healthy controlsQ33803377
Stress, food, and inflammation: psychoneuroimmunology and nutrition at the cutting edgeQ33843562
Stress and inflammation reduce brain-derived neurotrophic factor expression in first-episode psychosis: a pathway to smaller hippocampal volumeQ33849008
Cytokines and the brain: implications for clinical psychiatryQ33900651
Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob miceQ34006674
Functional specialization of interleukin-17 family membersQ34025860
Role of the gut microbiota in immunity and inflammatory diseaseQ34036490
Inflammatory molecular signature associated with infectious agents in psychosisQ34048637
Stress in schizophrenia: an integrative viewQ34061090
Effects of antipsychotic drugs on cytokine networksQ34133802
Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulinQ34166632
The immune system and schizophrenia. An integrative view.Q34194859
Consensus development conference on antipsychotic drugs and obesity and diabetesQ34293049
Anti-inflammatory treatment in schizophreniaQ34313482
P921main subjectschizophreniaQ41112
P304page(s)221
P577publication date2017-11-06
P1433published inFrontiers in PsychiatryQ27723495
P1476titleInterleukin-6 in Schizophrenia-Is There a Therapeutic Relevance?
P478volume8

Reverse relations

cites work (P2860)
Q91647621Inflammation as the Potential Basis in Depression
Q100695930Protein kinase C eta is activated in reactive astrocytes of an Alzheimer's disease mouse model: Evidence for its immunoregulatory function in primary astrocytes
Q64232326The Effects of Exercise on IL-6 Levels and Cognitive Performance in Patients with Schizophrenia

Search more.