Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ1-42-Induced Rat Model of Alzheimer's Disease

scientific article published on 19 September 2017

Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ1-42-Induced Rat Model of Alzheimer's Disease is …
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scholarly articleQ13442814

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P356DOI10.1155/2017/7464872
P932PMC publication ID5625750
P698PubMed publication ID29057264

P50authorChenxia ShengQ88269564
Zhe WangQ89391332
Chunhu ZhangQ89767682
P2093author name stringPanpan Xu
Dan Deng
Kexin Zhou
P2860cites workAmitriptyline-mediated cognitive enhancement in aged 3×Tg Alzheimer's disease mice is associated with neurogenesis and neurotrophic activityQ27334070
Clinical validity of cerebrospinal fluid Aβ42, tau, and phospho-tau as biomarkers for Alzheimer's disease in the context of a structured 5-phase development frameworkQ30235198
Intranasal BMP9 Ameliorates Alzheimer Disease-Like Pathology and Cognitive Deficits in APP/PS1 Transgenic Mice.Q30362847
Icariin ameliorates neuropathological changes, TGF-β1 accumulation and behavioral deficits in a mouse model of cerebral amyloidosisQ34015802
TrkB kinase activity maintains synaptic function and structural integrity at adult neuromuscular junctions.Q34353914
Synaptic changes in the dentate gyrus of APP/PS1 transgenic mice revealed by electron microscopyQ34667356
Molecular mechanisms of environmental enrichment: impairments in Akt/GSK3β, neurotrophin-3 and CREB signalingQ34735544
Icariin Prevents Amyloid Beta-Induced Apoptosis via the PI3K/Akt Pathway in PC-12 CellsQ35078698
Structural synaptic plasticity has high memory capacity and can explain graded amnesia, catastrophic forgetting, and the spacing effectQ35173537
Oridonin Attenuates Synaptic Loss and Cognitive Deficits in an Aβ1-42-Induced Mouse Model of Alzheimer's DiseaseQ35956077
Impact of 2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-D-glucoside on cognitive deficits in animal models of Alzheimer's disease: a systematic reviewQ36114503
The Protective Effect of Icariin on Mitochondrial Transport and Distribution in Primary Hippocampal Neurons from 3× Tg-AD MiceQ36666964
Apathy and APOE4 are associated with reduced BDNF levels in Alzheimer's diseaseQ37062425
Protective effect of tetrahydroxy stilbene glucoside on learning and memory by regulating synaptic plasticityQ37387287
Local and Use-Dependent Effects of β-Amyloid Oligomers on NMDA Receptor Function Revealed by Optical Quantal AnalysisQ37444982
Osthole Upregulates BDNF to Enhance Adult Hippocampal Neurogenesis in APP/PS1 Transgenic Mice.Q50558086
Icariin, a major constituent of flavonoids from Epimedium brevicornum, protects against cognitive deficits induced by chronic brain hypoperfusion via its anti-amyloidogenic effect in rats.Q50561717
Icariin, a phosphodiesterase-5 inhibitor, improves learning and memory in APP/PS1 transgenic mice by stimulation of NO/cGMP signalling.Q50689475
The Interplay of Akt and ERK in Aβ Toxicity and Insulin-Mediated Protection in Primary Hippocampal Cell Culture.Q52925339
Alzheimer disease: Localized proteomics distinguishes AD subtypes.Q53387950
Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate.Q37558841
Brain-Derived Neurotrophic Factor Serum Levels and Hippocampal Volume in Mild Cognitive Impairment and Dementia due to Alzheimer DiseaseQ37562884
Icariin decreases the expression of APP and BACE-1 and reduces the β-amyloid burden in an APP transgenic mouse model of Alzheimer's diseaseQ37589651
Evidence for benefit of statins to modify cognitive decline and risk in Alzheimer's diseaseQ37650830
Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brainQ37715875
BDNF-induced local protein synthesis and synaptic plasticityQ38100505
Brain-Derived Neurotrophic Factor in Alzheimer's Disease: Risk, Mechanisms, and TherapyQ38263685
Circular RNAs in Brain and Other Tissues: A Functional EnigmaQ38905226
Nitric oxide signaling is recruited as a compensatory mechanism for sustaining synaptic plasticity in Alzheimer's disease miceQ40027781
Icariin reverses corticosterone-induced depression-like behavior, decrease in hippocampal brain-derived neurotrophic factor (BDNF) and metabolic network disturbances revealed by NMR-based metabonomics in ratsQ40352389
The APP Intracellular Domain Is Required for Normal Synaptic Morphology, Synaptic Plasticity, and Hippocampus-Dependent Behavior.Q40874327
PFOS Disturbs BDNF-ERK-CREB Signalling in Association with Increased MicroRNA-22 in SH-SY5Y Cells.Q41822956
Autocrine BDNF-TrkB signalling within a single dendritic spine.Q41888614
Naoling decoction restores cognitive function by inhibiting the neuroinflammatory network in a rat model of Alzheimer's diseaseQ42075299
Distinct Hippocampal Expression Profiles of Long Non-coding RNAs in an Alzheimer's Disease ModelQ42339277
GSK-3β overexpression causes reversible alterations on postsynaptic densities and dendritic morphology of hippocampal granule neurons in vivo.Q42686888
Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mQ42737591
Icariin isolated from Epimedium brevicornum Maxim attenuates learning and memory deficits induced by d-galactose in rats.Q43010612
Icariin inhibits beta-amyloid peptide segment 25-35 induced expression of beta-secretase in rat hippocampusQ43271075
Self-assembly of Abeta(1-42) into globular neurotoxins.Q44641181
Akt activity in Alzheimer's disease and other neurodegenerative disordersQ44838986
Impaired fear extinction learning in adult heterozygous BDNF knock-out miceQ46502669
TGF-beta 1 protects against Abeta-neurotoxicity via the phosphatidylinositol-3-kinase pathway.Q46690418
Age-dependent deficits in fear learning in heterozygous BDNF knock-out miceQ47942079
Alzheimer's disease and type 2 diabetes-related alterations in brain mitochondria, autophagy and synaptic markersQ48184714
Tetrahydroxystilbene glucoside improves the learning and memory of amyloid-β(₁₋₄₂)-injected rats and may be connected to synaptic changes in the hippocampusQ48280002
Risperidone ameliorated Aβ1-42-induced cognitive and hippocampal synaptic impairments in miceQ48354813
Formononetin attenuates Aβ25-35-induced cytotoxicity in HT22 cells via PI3K/Akt signaling and non-amyloidogenic cleavage of APP.Q48377891
Girdin phosphorylation is crucial for synaptic plasticity and memory: a potential role in the interaction of BDNF/TrkB/Akt signaling with NMDA receptor.Q48462865
Early effects of Aβ1-42 oligomers injection in mice: Involvement of PI3K/Akt/GSK3 and MAPK/ERK1/2 pathways.Q48584465
Dysregulation of TrkB Receptors and BDNF Function by Amyloid-β Peptide is Mediated by CalpainQ48769291
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
P304page(s)7464872
P577publication date2017-09-19
P1433published inBioMed Research InternationalQ17509958
P1476titleIcariin Attenuates Synaptic and Cognitive Deficits in an Aβ1-42-Induced Rat Model of Alzheimer's Disease
P478volume2017