High Level of Tobacco Carcinogen-Derived DNA Damage in Oral Cells Is an Independent Predictor of Oral/Head and Neck Cancer Risk in Smokers.

scientific article published on 5 July 2017

High Level of Tobacco Carcinogen-Derived DNA Damage in Oral Cells Is an Independent Predictor of Oral/Head and Neck Cancer Risk in Smokers. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1158/1940-6207.CAPR-17-0140
P932PMC publication ID5712492
P698PubMed publication ID28679497

P50authorDorothy HatsukamiQ87445426
Irina StepanovQ42174081
P2093author name stringBin Ma
Samir S Khariwala
Stephen S Hecht
Steven G Carmella
Bruce Lindgren
Chris Ruszczak
P2860cites workImproved method for determination of 1-hydroxypyrene in human urineQ44973085
Mass spectrometric analysis of tobacco-specific nitrosamine-DNA adducts in smokers and nonsmokersQ44983753
Ultrasensitive method for the determination of 4-hydroxy-1-(3-pyridyl)-1-butanone-releasing DNA adducts by gas chromatography-high resolution mass spectrometry in mucosal biopsies of the lower esophagusQ46185375
4-Hydroxy-1-(3-pyridyl)-1-butanone-releasing DNA adducts in lung, lower esophagus and cardia of sudden death victimsQ46776068
Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosaminesQ47978013
Metabolic activation of N-alkylnitrosamines in genetically engineered Salmonella typhimurium expressing CYP2E1 or CYP2A6 together with human NADPH-cytochrome P450 reductase.Q50120819
Mass spectrometric analysis of 4-hydroxy-1-(3-pyridyl)-1-butanone-releasing DNA adducts in human lung.Q53336408
Development of a human biomonitoring assay using buccal mucosa: comparison of smoking-related DNA adducts in mucosa versus biopsiesQ72610958
1,N2-propanodeoxyguanosine adducts: potential new biomarkers of smoking-induced DNA damage in human oral tissueQ74251070
Lung carcinogenesis by tobacco smokeQ24625044
Mechanisms and implications of the age-associated decrease in DNA repair capacityQ30883526
Factors that influence the mutagenic patterns of DNA adducts from chemical carcinogensQ34053164
Ethanol-mediated regulation of cytochrome P450 2A6 expression in monocytes: role of oxidative stress-mediated PKC/MEK/Nrf2 pathwayQ34243809
Effects of watercress consumption on urinary metabolites of nicotine in smokersQ34505594
Quantitation of a minor enantiomer of phenanthrene tetraol in human urine: correlations with levels of overall phenanthrene tetraol, benzo[a]pyrene tetraol, and 1-hydroxypyrene.Q34793024
Gender and ethnic disparities in incidence and survival of squamous cell carcinoma of the oral tongue, base of tongue, and tonsils: a surveillance, epidemiology and end results program-based analysisQ35268034
Urinary levels of the tobacco-specific carcinogen N'-nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risk in smokers.Q35452161
Elevated levels of 1-hydroxypyrene and N'-nitrosonornicotine in smokers with head and neck cancer: A matched control studyQ35566185
Self-reported Tobacco use does not correlate with carcinogen exposure in smokers with head and neck cancerQ35883271
Age and gender effects on DNA strand break repair in peripheral blood mononuclear cellsQ36101146
Combined analysis of N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in the urine of cigarette smokers and e-cigarette usersQ36419992
A prospectively measured serum biomarker for a tobacco-specific carcinogen and lung cancer in smokersQ36441730
Urinary levels of tobacco-specific nitrosamine metabolites in relation to lung cancer development in two prospective cohorts of cigarette smokersQ37149026
(S)-N'-Nitrosonornicotine, a constituent of smokeless tobacco, is a powerful oral cavity carcinogen in ratsQ37151645
High throughput liquid and gas chromatography-tandem mass spectrometry assays for tobacco-specific nitrosamine and polycyclic aromatic hydrocarbon metabolites associated with lung cancer in smokersQ37243159
Clear differences in levels of a formaldehyde-DNA adduct in leukocytes of smokers and nonsmokers.Q37350290
Exposure and Metabolic Activation Biomarkers of Carcinogenic Tobacco-Specific Nitrosamines.Q37499926
Tobacco-specific N-nitrosamine exposures and cancer risk in the Shanghai Cohort Study: remarkable coherence with rat tumor sitesQ37629435
Optimized Liquid Chromatography Nanoelectrospray-High-Resolution Tandem Mass Spectrometry Method for the Analysis of 4-Hydroxy-1-(3-pyridyl)-1-butanone-Releasing DNA Adducts in Human Oral CellsQ38822160
Analysis of 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB)-releasing DNA adducts in human exfoliated oral mucosa cells by liquid chromatography-electrospray ionization-tandem mass spectrometryQ39972678
Gender differences in age-related decline in DNA double-strand break damage and repair in lymphocytesQ41171873
Evidence for 4-(3-pyridyl)-4-oxobutylation of DNA in F344 rats treated with the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine.Q41432966
Cytochrome P450 2A-catalyzed metabolic activation of structurally similar carcinogenic nitrosamines: N'-nitrosonornicotine enantiomers, N-nitrosopiperidine, and N-nitrosopyrrolidineQ42042660
Does enhancing partner support and interaction improve smoking cessation? A meta-analysisQ42090479
Quantitation of urinary metabolites of a tobacco-specific lung carcinogen after smoking cessationQ42536153
Mechanistic relationships between DNA adducts, oncogene mutations, and lung tumorigenesis in strain A miceQ42541164
An investigation of mutation as a function of age in humans.Q43515461
Identification of adducts formed by pyridyloxobutylation of deoxyguanosine and DNA by 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone, a chemically activated form of tobacco specific carcinogensQ44446682
Nicotine metabolite ratio as a predictor of cigarette consumptionQ44631526
Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activityQ44960529
P433issue9
P921main subjectneck cancerQ18966654
P304page(s)507-513
P577publication date2017-07-05
P1433published inCancer Prevention ResearchQ2665103
P1476titleHigh Level of Tobacco Carcinogen-Derived DNA Damage in Oral Cells Is an Independent Predictor of Oral/Head and Neck Cancer Risk in Smokers
P478volume10

Reverse relations

cites work (P2860)
Q89685288Applying tobacco, environmental and dietary-related biomarkers to understand cancer etiology and evaluate prevention strategies
Q89522861Dietary phytochemicals as the potential protectors against carcinogenesis and their role in cancer chemoprevention
Q59137544Tobacco carcinogen research to aid understanding of cancer risk and influence policy

Search more.