Investigations on the dose-response relationship of combined exposure to low doses of three anti-androgens in Wistar rats

scientific article published on 6 September 2017

Investigations on the dose-response relationship of combined exposure to low doses of three anti-androgens in Wistar rats is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00204-017-2053-3
P932PMC publication ID5719133
P698PubMed publication ID28879601

P50authorKarma C FussellQ59275737
Volker StraussQ59275742
Bennard van RavenzwaayQ66360700
P2093author name stringSteffen Schneider
Stephanie Melching-Kollmuss
Xiaoqi Jiang
Sibylle Gröters
Roland Buesen
P2860cites workCumulative effects of in utero administration of mixtures of reproductive toxicants that disrupt common target tissues via diverse mechanisms of toxicityQ24607688
Sensitivity of fetal rat testicular steroidogenesis to maternal prochloraz exposure and the underlying mechanism of inhibitionQ28568706
Antiandrogenic effects in male rats perinatally exposed to a mixture of di(2-ethylhexyl) phthalate and di(2-ethylhexyl) adipateQ29395733
Simultaneous quantitation of testosterone and estradiol in human cell line (H295R) by liquid chromatography/positive atmospheric pressure photoionization tandem mass spectrometryQ33452024
Synergistic disruption of external male sex organ development by a mixture of four antiandrogensQ33562958
Assessing the risks of exposures to multiple chemicals with a common mechanism of toxicity: how to cumulate?Q33861661
Recognition of adverse and nonadverse effects in toxicity studiesQ34560285
Tissue interaction in androgen response of embryonic mammary rudiment of mouse: identification of target tissue for testosteroneQ35035898
Combined exposure to anti-androgens exacerbates disruption of sexual differentiation in the rat.Q36326633
Adverse effects of environmental antiandrogens and androgens on reproductive development in mammalsQ36391045
Cumulative risk assessment of pesticide residues in food.Q37201801
Mechanisms of action of phthalate esters, individually and in combination, to induce abnormal reproductive development in male laboratory ratsQ37307781
Cumulative effects of in utero administration of mixtures of "antiandrogens" on male rat reproductive development.Q37369686
Weight-of-evidence analysis of human exposures to dioxins and dioxin-like compounds and associations with thyroid hormone levels during early developmentQ37736663
Low-dose effects and nonmonotonic dose-responses of endocrine disrupting chemicals: has the case been made?Q38023046
Proliferative and nonproliferative lesions of the rat and mouse male reproductive systemQ38040759
Anti-androgenicity can only be evaluated using a weight of evidence approachQ38159158
Investigations of putative reproductive toxicity of low-dose exposures to vinclozolin in Wistar rats.Q39406079
Combination effects of azole fungicides in male rats in a broad dose rangeQ39730383
Mixture effects of endocrine disrupting compounds in vitro.Q39743721
Comparing effect levels of regulatory studies with endpoints derived in targeted anti-androgenic studies: example prochloraz.Q39969308
Mechanisms of action underlying the antiandrogenic effects of the fungicide prochlorazQ40336569
Investigations of putative reproductive toxicity of low-dose exposures to flutamide in Wistar ratsQ40366127
The combined antiandrogenic effects of five commonly used pesticides.Q42172005
Reproductive toxicity of 2-methoxyethanol applied dermally to occluded and nonoccluded sites in male ratsQ42198808
Evaluation of a peripherally selective antiandrogen (Casodex) as a tool for studying the relationship between testosterone and spermatogenesis in the ratQ43407030
Effects of currently used pesticides in assays for estrogenicity, androgenicity, and aromatase activity in vitroQ43909287
Dansyl chloride derivatization of methamphetamine: a method with advantages for screening and analysis of methamphetamine in urineQ43912258
Endocrine active agents: implications of adverse and non-adverse changesQ43916869
Cumulative effects of dibutyl phthalate and diethylhexyl phthalate on male rat reproductive tract development: altered fetal steroid hormones and genesQ44869977
A mixture of seven antiandrogens induces reproductive malformations in ratsQ44872672
Cumulative and antagonistic effects of a mixture of the antiandrogens vinclozolin and iprodione in the pubertal male rat.Q44877692
Relevance weighting of tier 1 endocrine screening endpoints by rank orderQ45233038
Reversibility of androgen deprivation therapy in patients with prostate cancerQ45265307
A mixture of five phthalate esters inhibits fetal testicular testosterone production in the sprague-dawley rat in a cumulative, dose-additive mannerQ46645636
Combined exposure to anti-androgens causes markedly increased frequencies of hypospadias in the rat.Q46721872
Diisobutyl phthalate has comparable anti-androgenic effects to di-n-butyl phthalate in fetal rat testisQ46927934
Scientific Opinion on the identification of pesticides to be included in cumulative assessment groups on the basis of their toxicological profileQ47153511
Scientific Opinion on the relevance of dissimilar mode of action and its appropriate application for cumulative risk assessment of pesticides residues in foodQ47154000
Revised guides for organ sampling and trimming in rats and mice – Part 1Q47382031
Feasibility of the extended one-generation reproductive toxicity study (OECD 443).Q47651414
Revised guides for organ sampling and trimming in rats and mice--Part 2. A joint publication of the RITA and NACAD groupsQ47923355
Persistent developmental toxicity in rat offspring after low dose exposure to a mixture of endocrine disrupting pesticides.Q50802992
Vinclozolin: A feasibility and sensitivity study of the ILSI-HESI F1-extended one-generation rat reproduction protocolQ51618571
Dysgenesis and histological changes of genitals and perturbations of gene expression in male rats after in utero exposure to antiandrogen mixtures.Q51917755
Toxicological evaluation of chemical mixtures.Q52041372
Rat sperm motility analysis: Methodologic considerationsQ60155578
In vitro analysis of the hormonal basis for the sexual dimorphism in the embryonic development of the mouse mammary glandQ71768273
Pre- and postnatal oral toxicity of vinclozolin in Wistar and Long-Evans ratsQ73071537
The problem of synergism and antagonism of combined drugsQ73248616
Revised guides for organ sampling and trimming in rats and mice--Part 3. A joint publication of the RITA and NACAD groupsQ80598587
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue12
P304page(s)3961-3989
P577publication date2017-09-06
P1433published inArchives of ToxicologyQ635837
P1476titleInvestigations on the dose-response relationship of combined exposure to low doses of three anti-androgens in Wistar rats
P478volume91

Reverse relations

cites work (P2860)
Q54959270Endocrine disrupting potency of organic pollutant mixtures isolated from commercial fish oil evaluated in yeast-based bioassays.
Q89263246Mixed "Antiandrogenic" Chemicals at Low Individual Doses Produce Reproductive Tract Malformations in the Male Rat
Q94453639Overview of the effects of chemical mixtures with endocrine disrupting activity in the context of real-life risk simulation: An integrative approach (Review)

Search more.