Restoring synaptic plasticity and memory in mouse models of Alzheimer's disease by PKR inhibition

scientific article published on 13 December 2017

Restoring synaptic plasticity and memory in mouse models of Alzheimer's disease by PKR inhibition is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1099597975
P356DOI10.1186/S13041-017-0338-3
P932PMC publication ID5727890
P698PubMed publication ID29233183

P2093author name stringSang Jeong Kim
Yong-Seok Lee
Sangmyung Rhee
Myeong Seong Bak
Kyoung-Doo Hwang
P2860cites workSuppression of PKR promotes network excitability and enhanced cognition by interferon-γ-mediated disinhibitionQ24622825
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Differential contribution of amygdala and hippocampus to cued and contextual fear conditioningQ29616330
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133Q29617856
Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesisQ30486959
Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficitsQ30543820
eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memoryQ30586619
Limited effects of an eIF2αS51A allele on neurological impairments in the 5xFAD mouse model of Alzheimer's diseaseQ30637868
Hippocampus and context in classical conditioningQ33632528
PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's diseaseQ34024468
Tonic inhibition in dentate gyrus impairs long-term potentiation and memory in an Alzheimer’s disease modelQ34157421
Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein.Q34323197
CREB1 encodes a nuclear activator, a repressor, and a cytoplasmic modulator that form a regulatory unit critical for long-term facilitationQ34477276
Cerebrospinal fluid PKR level predicts cognitive decline in Alzheimer's diseaseQ34548296
The molecular and cellular biology of enhanced cognitionQ34925043
Deletion of the eIF2α Kinase GCN2 fails to rescue the memory decline associated with Alzheimer's diseaseQ35023108
Increasing CREB function in the CA1 region of dorsal hippocampus rescues the spatial memory deficits in a mouse model of Alzheimer's diseaseQ35222767
The novel object recognition memory: neurobiology, test procedure, and its modificationsQ35904451
Amyloid β-protein oligomers upregulate the β-secretase, BACE1, through a post-translational mechanism involving its altered subcellular distribution in neuronsQ36263251
Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse modelQ37341124
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The neurotoxicity of amyloid β-protein oligomers is reversible in a primary neuron model.Q37615463
Roles of eIF2α kinases in the pathogenesis of Alzheimer's diseaseQ37718976
Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2α pathwayQ39401343
Binding of double-stranded RNA to protein kinase PKR is required for dimerization and promotes critical autophosphorylation events in the activation loop.Q43597902
Blocking the eIF2α kinase (PKR) enhances positive and negative forms of cortex-dependent taste memory.Q45275219
Memantine rescues transient cognitive impairment caused by high-molecular-weight aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers.Q46518657
PKR Inhibition Rescues Memory Deficit and ATF4 Overexpression in ApoE ε4 Human Replacement MiceQ47641854
Effects of interferons and hydrogen peroxide on CA3 pyramidal cells in rat hippocampal slice culturesQ48233419
The dorsal hippocampus is essential for context discrimination but not for contextual conditioningQ48397925
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.Q48404445
Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study 'recognition memory'.Q48406875
Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's diseaseQ48419985
Reversible inhibition of CREB/ATF transcription factors in region CA1 of the dorsal hippocampus disrupts hippocampus-dependent spatial memoryQ48617027
P433issue1
P921main subjectAlzheimer's diseaseQ11081
synaptic plasticityQ1551556
P304page(s)57
P577publication date2017-12-13
P1433published inMolecular BrainQ6895938
P1476titleRestoring synaptic plasticity and memory in mouse models of Alzheimer's disease by PKR inhibition
P478volume10

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cites work (P2860)
Q56999989APOE and Alzheimer’s Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimer’s Pathogenesis
Q96225135Glycogen synthase kinase (GSK)-3 and the double-strand RNA-dependent kinase, PKR: When two kinases for the common good turn bad
Q61449861PKR: A Kinase to Remember
Q93089064RNAs and RNA-Binding Proteins in Immuno-Metabolic Homeostasis and Diseases
Q64245877SET SUMOylation promotes its cytoplasmic retention and induces tau pathology and cognitive impairments
Q90419881TGF-β1 Restores Hippocampal Synaptic Plasticity and Memory in Alzheimer Model via the PI3K/Akt/Wnt/β-Catenin Signaling Pathway
Q92257585The Potential Role of MicroRNA-124 in Cerebral Ischemia Injury
Q55438723Transcription-independent expression of PKMζ in the anterior cingulate cortex contributes to chronically maintained neuropathic pain.

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