Alternative evolutionary histories in the sequence space of an ancient protein.

scientific article published on 13 September 2017

Alternative evolutionary histories in the sequence space of an ancient protein. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1091606518
P356DOI10.1038/NATURE23902
P932PMC publication ID6214350
P698PubMed publication ID28902834

P2093author name stringJoseph W Thornton
Lora K Picton
Tyler N Starr
P2860cites workStability-mediated epistasis constrains the evolution of an influenza proteinQ21128791
Experimental illumination of a fitness landscapeQ22066261
The FoldX web server: an online force fieldQ24530376
Prediction of water and metal binding sites and their affinities by using the Fold-X force fieldQ24531531
Crystal structure of an ancient protein: evolution by conformational epistasisQ24658018
Sort-seq under the hood: implications of design choices on large-scale characterization of sequence-function relationsQ27316616
Crystallographic analysis of the interaction of the glucocorticoid receptor with DNAQ27651364
An epistatic ratchet constrains the direction of glucocorticoid receptor evolutionQ27657553
The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elementsQ27731441
WebLogo: A Sequence Logo GeneratorQ27860646
Yeast vectors for the controlled expression of heterologous proteins in different genetic backgroundsQ28131643
Contingency and entrenchment in protein evolution under purifying selectionQ28647800
Detecting High-Order Epistasis in Nonlinear Genotype-Phenotype MapsQ29002206
Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol methodQ29547550
Genome-wide analysis of estrogen receptor binding sitesQ29614765
Historical contingency and its biophysical basis in glucocorticoid receptor evolution.Q30363637
Quantifying and resolving multiple vector transformants in S. cerevisiae plasmid librariesQ30906479
An improved yeast transformation method for the generation of very large human antibody librariesQ33529366
High-resolution mapping of protein sequence-function relationshipsQ33658465
Permissive secondary mutations enable the evolution of influenza oseltamivir resistanceQ34118992
Natural Selection and the Concept of a Protein SpaceQ34233063
Evolutionary biochemistry: revealing the historical and physical causes of protein properties.Q34358160
Evolutionary meandering of intermolecular interactions along the drift barrierQ34926385
The (mis)use of overlap of confidence intervals to assess effect modificationQ34940220
Short barcodes for next generation sequencingQ35080096
Evolution of distinct DNA-binding specificities within the nuclear receptor family of transcription factorsQ35219531
Measuring the activity of protein variants on a large scale using deep mutational scanningQ35234062
Protein evolution. Pervasive degeneracy and epistasis in a protein-protein interface.Q35556345
How structural and physicochemical determinants shape sequence constraints in a functional enzymeQ35565904
Evolution of DNA specificity in a transcription factor family produced a new gene regulatory moduleQ35660386
Evolving new protein-protein interaction specificity through promiscuous intermediates.Q35811852
Predictable convergence in hemoglobin function has unpredictable molecular underpinningsQ36193142
Experimental interrogation of the path dependence and stochasticity of protein evolution using phage-assisted continuous evolutionQ36895756
The glucocorticoid receptor dimer interface allosterically transmits sequence-specific DNA signalsQ36986235
L1 penalized continuation ratio models for ordinal response prediction using high-dimensional datasetsQ37031400
Local fitness landscape of the green fluorescent proteinQ37142510
Adaptation in protein fitness landscapes is facilitated by indirect pathsQ37175865
Epistasis in protein evolutionQ38718935
Reconstructing Ancient Proteins to Understand the Causes of Structure and FunctionQ39182229
NUCPLOT: a program to generate schematic diagrams of protein-nucleic acid interactionsQ39722057
Intermolecular epistasis shaped the function and evolution of an ancient transcription factor and its DNA binding sitesQ41342939
The nuclear receptor superfamily has undergone extensive proliferation and diversification in nematodesQ42692444
Glucocorticoid receptor-DNA interactions: binding energetics are the primary determinant of sequence-specific transcriptional activityQ43894272
Neutralism and selectionism: a network-based reconciliationQ46669644
Robustness of Reconstructed Ancestral Protein Functions to Statistical Uncertainty.Q47262312
An evolvable oestrogen receptor activity sensor: development of a modular system for integrating multiple genes into the yeast genomeQ47599406
P433issue7672
P407language of work or nameEnglishQ1860
P304page(s)409-413
P577publication date2017-09-13
P1433published inNatureQ180445
P1476titleAlternative evolutionary histories in the sequence space of an ancient protein
P478volume549

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cites work (P2860)
Q99233817Amalgamated cross-species transcriptomes reveal organ-specific propensity in gene expression evolution
Q52559094Ancestral function and diversification of a horizontally acquired oomycete carboxylic acid transporter.
Q83225728Asymmetrical diversification of the receptor-ligand interaction controlling self-incompatibility in Arabidopsis
Q113307197Building, Importing, and Exporting GEXF Graph Files with rgexf
Q47281158Characteristics of a PHD Finger Subtype.
Q90413944Combinatorial mutagenesis of rapidly evolving residues yields super-restrictor antiviral proteins
Q47383675Compensatory mutations and epistasis for protein function
Q61799270Cryptic genetic variation shapes the adaptive evolutionary potential of enzymes
Q64067701Cycles of external dependency drive evolution of avian carotenoid networks
Q56888351Deep mutational scanning of hemagglutinin helps predict evolutionary fates of human H3N2 influenza variants
Q92826886Determining protein structures using deep mutagenesis
Q90911730Engineering orthogonal signalling pathways reveals the sparse occupancy of sequence space
Q90425383Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance
Q91850685Functional assays for transcription mechanisms in high-throughput
Q58541909Functional trade-offs and environmental variation shaped ancient trajectories in the evolution of dim-light vision
Q90860005Higher-order epistasis shapes the fitness landscape of a xenobiotic-degrading enzyme
Q55318229How single mutations affect viral escape from broad and narrow antibodies to H1 influenza hemagglutinin.
Q53820041Hsp90 shapes protein and RNA evolution to balance trade-offs between protein stability and aggregation.
Q92826872Inferring protein 3D structure from deep mutation scans
Q58752936Intrinsic cooperativity potentiates parallel -regulatory evolution
Q52591749Mapping the Evolutionary Potential of RNA Viruses.
Q91891435Minimum epistasis interpolation for sequence-function relationships
Q99545328Mutational resilience of antiviral restriction favors primate TRIM5α in host-virus evolutionary arms races
Q83225140Mutations that improve efficiency of a weak-link enzyme are rare compared to adaptive mutations elsewhere in the genome
Q55379339RNA-mediated gene regulation is less evolvable than transcriptional regulation.
Q58570246The causes of evolvability and their evolution
Q90380825The evolution of metabolism: How to test evolutionary hypotheses at the genomic level
Q58749822Tracing a protein's folding pathway over evolutionary time using ancestral sequence reconstruction and hydrogen exchange
Q90833342Understanding molecular mechanisms in cell signaling through natural and artificial sequence variation

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