| scholarly article | Q13442814 |
| review article | Q7318358 |
| P50 | author | Linda Griffith | Q6551615 |
| D. L. Taylor | Q67525254 | ||
| Sarah E. Wheeler | Q42713783 | ||
| P2093 | author name string | Donna B Stolz | |
| Alan Wells | |||
| Amanda M Clark | |||
| Colin H Beckwitt | |||
| P2860 | cites work | IP-10 induces dissociation of newly formed blood vessels | Q24314328 |
| Fluorescent protein biosensors applied to microphysiological systems | Q26827752 | ||
| Engineering liver | Q26864348 | ||
| Human induced pluripotent stem cell-based microphysiological tissue models of myocardium and liver for drug development | Q26995580 | ||
| A review of the methods for human iPSC derivation | Q27016051 | ||
| Liver sinusoidal endothelial cells and liver regeneration | Q27027903 | ||
| Stem cells, cancer, and cancer stem cells | Q27860878 | ||
| Epigenetic memory in induced pluripotent stem cells | Q29547892 | ||
| Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver | Q29616840 | ||
| Differentiation and enrichment of hepatocyte-like cells from human embryonic stem cells in vitro and in vivo | Q33299826 | ||
| Hepatic nonparenchymal cells drive metastatic breast cancer outgrowth and partial epithelial to mesenchymal transition | Q33565909 | ||
| Cytochrome P-450 3A4: regulation and role in drug metabolism | Q33636632 | ||
| Towards a three-dimensional microfluidic liver platform for predicting drug efficacy and toxicity in humans | Q33641648 | ||
| All-human microphysical model of metastasis therapy | Q33641654 | ||
| HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease | Q33642614 | ||
| Effects of liver disease on pharmacokinetics. An update | Q33789233 | ||
| Oxygen: modulator of metabolic zonation and disease of the liver | Q33828310 | ||
| Isolation of primary human hepatocytes from normal and diseased liver tissue: a one hundred liver experience | Q33867498 | ||
| Reprogramming induced pluripotent stem cells in the absence of c-Myc for differentiation into hepatocyte-like cells | Q33928366 | ||
| Micropatterned cell-cell interactions enable functional encapsulation of primary hepatocytes in hydrogel microtissues | Q34063544 | ||
| In vitro platforms for evaluating liver toxicity | Q34143314 | ||
| Immortalized liver endothelial cells: a cell culture model for studies of motility and angiogenesis. | Q34354070 | ||
| Establishment of c-myc-immortalized Kupffer cell line from a C57BL/6 mouse strain | Q34424719 | ||
| Human hepatocytes: isolation, cryopreservation and applications in drug development | Q34608510 | ||
| Spontaneous dormancy of metastatic breast cancer cells in an all human liver microphysiologic system | Q34687026 | ||
| Similarities and differences in the expression of drug-metabolizing enzymes between human hepatic cell lines and primary human hepatocytes | Q34702564 | ||
| Metabolomics-on-a-chip of hepatotoxicity induced by anticancer drug flutamide and Its active metabolite hydroxyflutamide using HepG2/C3a microfluidic biochips | Q42716716 | ||
| Micromolding of photocrosslinkable chitosan hydrogel for spheroid microarray and co-cultures | Q42799569 | ||
| Radial flow hepatocyte bioreactor using stacked microfabricated grooved substrates | Q42826610 | ||
| Activation of human liver sinusoidal endothelial cell by human platelets induces hepatocyte proliferation | Q42975901 | ||
| Species comparison in P450 induction: effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man, Sprague-Dawley rat, minipig, and beagle dog. | Q43597482 | ||
| Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans. | Q43740204 | ||
| Cryopreservation of adult human hepatocytes obtained from resected liver biopsies | Q44084954 | ||
| Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties | Q44516229 | ||
| A simple method for the simultaneous isolation of stellate cells and hepatocytes from rat liver tissue | Q44518193 | ||
| Determination of cytochrome P450 1A2 and cytochrome P450 3A4 induction in cryopreserved human hepatocytes | Q44809802 | ||
| Species differences in the pharmacokinetics and metabolism of indinavir, a potent human immunodeficiency virus protease inhibitor. | Q44994091 | ||
| Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance | Q45001535 | ||
| The impact of solute carrier (SLC) drug uptake transporter loss in human and rat cryopreserved hepatocytes on clearance predictions | Q45357490 | ||
| Influence of the molecular weight of poly(lactide-co-glycolide) on the in vivo cartilage repair by a construct of poly(lactide-co-glycolide)/fibrin gel/mesenchymal stem cells/transforming growth factor-β1. | Q45791172 | ||
| An artificial liver sinusoid with a microfluidic endothelial-like barrier for primary hepatocyte culture | Q46254913 | ||
| Species differences and interindividual variation in liver microsomal cytochrome P450 2A enzymes: effects on coumarin, dicumarol, and testosterone oxidation | Q46603479 | ||
| Solubilized liver extracellular matrix maintains primary rat hepatocyte phenotype in-vitro | Q46618879 | ||
| A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity | Q46648491 | ||
| Novel hepatocyte culture system developed using microfabrication and collagen/polyethylene glycol microcontact printing. | Q46659892 | ||
| Isolation of primary human hepatocytes after partial hepatectomy: criteria for identification of the most promising liver specimen | Q46803989 | ||
| Cryopreservation-induced nonattachment of human hepatocytes: role of adhesion molecules | Q46969456 | ||
| The effect of three-dimensional co-culture of hepatocytes and hepatic stellate cells on key hepatocyte functions in vitro | Q46988734 | ||
| Meeting the challenge of predicting hepatic clearance of compounds slowly metabolized by cytochrome P450 using a novel hepatocyte model, HepatoPac | Q47743301 | ||
| Developmental expression of cytochrome P450 enzymes in human liver | Q47912147 | ||
| A prospective study of isolated human hepatocyte function following liver resection for colorectal liver metastases: the effects of prior exposure to chemotherapy. | Q50479869 | ||
| Efficient differentiation of functional hepatocytes from human embryonic stem cells. | Q50645303 | ||
| Rat liver sinusoidal endothelial cells survive without exogenous VEGF in 3D perfused co-cultures with hepatocytes. | Q50689829 | ||
| Microscale culture of human liver cells for drug development. | Q50859383 | ||
| Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems. | Q50916795 | ||
| Microfluidic environment for high density hepatocyte culture. | Q50941237 | ||
| A liver microphysiological system of tumor cell dormancy and inflammatory responsiveness is affected by scaffold properties. | Q51089323 | ||
| Contribution of non-parenchymal cells to the performance of micropatterned hepatocytes. | Q51134062 | ||
| Tissue collection, transport and isolation procedures required to optimize human hepatocyte isolation from waste liver surgical resections. A multilaboratory study. | Q51637422 | ||
| Novel developmental biology-based protocol of embryonic stem cell differentiation to morphologically sound and functional yet immature hepatocytes. | Q51819533 | ||
| Evaluation of child/adult pharmacokinetic differences from a database derived from the therapeutic drug literature. | Q52122632 | ||
| Quantitative measurement of human tissue hepatic blood volume by C15O inhalation with positron-emission tomography. | Q52299985 | ||
| Long-Term Stability of Cryopreserved Human Hepatocytes: Evaluation of Phase I and II Drug-Metabolizing Enzyme Activities and CYP3A4/5 Induction for More than a Decade. | Q52776755 | ||
| Protocol for Isolation of Primary Human Hepatocytes and Corresponding Major Populations of Non-parenchymal Liver Cells. | Q52853586 | ||
| Analysis of drug metabolism activities in a miniaturized liver cell bioreactor for use in pharmacological studies. | Q52887959 | ||
| Evaluation of cryopreserved human hepatocytes as an alternative in vitro system to microsomes for the prediction of metabolic clearance. | Q53013898 | ||
| Human hepatocytes with drug metabolic function induced from fibroblasts by lineage reprogramming. | Q53609327 | ||
| Hepatocyte cocultures with endothelial cells and fibroblasts on micropatterned fibrous mats to promote liver-specific functions and capillary formation capabilities. | Q53618591 | ||
| Perfusion culture of fetal human hepatocytes in microfluidic environments | Q56225301 | ||
| Potential Impact of Steatosis on Cytochrome P450 Enzymes of Human Hepatocytes Isolated from Fatty Liver Grafts | Q58681129 | ||
| Human cytochrome P450 maximal activities in pediatric versus adult liver | Q73566803 | ||
| Effect of flow on the detoxification function of rat hepatocytes in a bioartificial liver reactor | Q77196361 | ||
| A microfabricated array bioreactor for perfused 3D liver culture | Q77838847 | ||
| Use of cryopreserved human hepatocytes in sandwich culture to measure hepatobiliary transport | Q79748061 | ||
| Differentiation of mouse embryonic stem cells to hepatocyte-like cells by co-culture with human liver nonparenchymal cell lines | Q80093469 | ||
| Isolation and culture of primary human hepatocytes | Q80551610 | ||
| Maintaining hepatocyte differentiation in vitro through co-culture with hepatic stellate cells | Q83274871 | ||
| Factors affecting hepatocyte isolation, engraftment, and replication in an in vivo model | Q84631341 | ||
| Expression and transport function of drug uptake transporters in differentiated HepaRG cells | Q84809540 | ||
| Isolation and culture of hepatic stellate cells from mouse liver | Q87034558 | ||
| Identification of small molecules for human hepatocyte expansion and iPS differentiation | Q34752148 | ||
| Cytochromes P450 and experimental models of drug metabolism. | Q34778084 | ||
| Modular bioreactor for primary human hepatocyte culture: medium flow stimulates expression and activity of detoxification genes. | Q35068949 | ||
| Layered patterning of hepatocytes in co-culture systems using microfabricated stencils | Q35138574 | ||
| Prediction of Drug-Induced Liver Injury in Micropatterned Co-cultures Containing iPSC-Derived Human Hepatocytes | Q35567915 | ||
| Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4α transduction. | Q35665145 | ||
| Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused three-dimensional human liver bioreactor | Q35745230 | ||
| Lipids promote survival, proliferation, and maintenance of differentiation of rat liver sinusoidal endothelial cells in vitro | Q35780887 | ||
| All-In-One: Advanced preparation of Human Parenchymal and Non-Parenchymal Liver Cells | Q35788567 | ||
| Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins | Q35828228 | ||
| Effect of patient, operative and isolation factors on subsequent yield and viability of human hepatocytes for research use. | Q35829508 | ||
| Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration | Q35831603 | ||
| The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes | Q35886027 | ||
| Macrophage secretory products induce an inflammatory phenotype in hepatocytes | Q35904291 | ||
| A microphysiological system model of therapy for liver micrometastases | Q36072561 | ||
| Acetaminophen cytotoxicity is ameliorated in a human liver organotypic co-culture model | Q36343336 | ||
| Role of Biotransformation in Drug-Induced Toxicity: Influence of Intra- and Inter-Species Differences in Drug Metabolism | Q36362377 | ||
| A human liver microphysiology platform for investigating physiology, drug safety, and disease models | Q36491320 | ||
| Hepatocytes in collagen sandwich: evidence for transcriptional and translational regulation | Q36530969 | ||
| Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction | Q36662865 | ||
| In vitro models for liver toxicity testing | Q36671339 | ||
| The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics | Q36714606 | ||
| Hepatic stellate cells in liver development, regeneration, and cancer | Q36793474 | ||
| Human induced pluripotent stem cells derived hepatocytes: rising promise for disease modeling, drug development and cell therapy | Q36923041 | ||
| A Perspective on Implementing a Quantitative Systems Pharmacology Platform for Drug Discovery and the Advancement of Personalized Medicine. | Q37029832 | ||
| Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. | Q37121662 | ||
| Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans | Q37363157 | ||
| Characterizing the effects of heparin gel stiffness on function of primary hepatocytes. | Q37376869 | ||
| Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle. | Q37630442 | ||
| General review on in vitro hepatocyte models and their applications | Q37774289 | ||
| From 3D cell culture to organs-on-chips | Q37950229 | ||
| Pluripotent stem cell-derived hepatocytes: potential and challenges in pharmacology. | Q38072100 | ||
| Role of the extracellular matrix in whole organ engineering | Q38172056 | ||
| Pluripotent stem cell-derived hepatocyte-like cells | Q38179753 | ||
| The role of Kupffer cells in hepatitis B and hepatitis C virus infections. | Q38209564 | ||
| Gene expression profiles during hepatic stellate cell activation in culture and in vivo | Q38302031 | ||
| Microengineered liver tissues for drug testing | Q38330579 | ||
| Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis. | Q38333252 | ||
| Perfused multiwell plate for 3D liver tissue engineering | Q38590052 | ||
| Multiparametric assay using HepaRG cells for predicting drug-induced liver injury | Q38880009 | ||
| A systematic comparison of the impact of inflammatory signaling on absorption, distribution, metabolism, and excretion gene expression and activity in primary human hepatocytes and HepaRG cells | Q38931771 | ||
| Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes. | Q38933941 | ||
| Polarized expression of drug transporters in differentiated human hepatoma HepaRG cells | Q39126388 | ||
| 3D organotypic cultures of human HepaRG cells: a tool for in vitro toxicity studies | Q39200237 | ||
| Pre-clinical and clinical investigations of metabolic zonation in liver diseases: The potential of microphysiology systems. | Q39280379 | ||
| Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co-culture biochip. | Q39570346 | ||
| Strategies to produce hepatocytes and hepatocyte-like cells from pluripotent stem cells | Q39698876 | ||
| Activated macrophages induce hepcidin expression in HuH7 hepatoma cells | Q39849441 | ||
| Application of Micropatterned Cocultured Hepatocytes to Evaluate the Inductive Potential and Degradation Rate of Major Xenobiotic Metabolizing Enzymes | Q40220726 | ||
| Tumor endothelial cells express epidermal growth factor receptor (EGFR) but not ErbB3 and are responsive to EGF and to EGFR kinase inhibitors | Q40314326 | ||
| Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line | Q40599455 | ||
| Human parenchymal and non-parenchymal liver cell isolation, culture and characterization | Q40706779 | ||
| Hepatocyte-supported serum-free culture of rat liver sinusoidal endothelial cells. | Q40761211 | ||
| Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease | Q40770241 | ||
| Role of hepatic non-parenchymal cells in the response of rat hepatocytes to the peroxisome proliferator nafenopin in vitro | Q40835154 | ||
| Cyclosporin A drug interactions. Screening for inducers and inhibitors of cytochrome P-450 (cyclosporin A oxidase) in primary cultures of human hepatocytes and in liver microsomes. | Q41176129 | ||
| An In Vitro Human Liver Model by iPSC-Derived Parenchymal and Non-parenchymal Cells | Q41326722 | ||
| The hepatic stellate (Ito) cell: its role in human liver disease | Q41429711 | ||
| Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human | Q41540508 | ||
| Co-regulation of primary mouse hepatocyte viability and function by oxygen and matrix | Q41831965 | ||
| A microfluidic hepatic coculture platform for cell-based drug metabolism studies | Q41845201 | ||
| Layered long-term co-culture of hepatocytes and endothelial cells on a transwell membrane: toward engineering the liver sinusoid | Q41979424 | ||
| Tissue specific synthetic ECM hydrogels for 3-D in vitro maintenance of hepatocyte function | Q42036215 | ||
| The Microphysiology Systems Database for Analyzing and Modeling Compound Interactions with Human and Animal Organ Models | Q42364728 | ||
| Featured Article: Isolation, characterization, and cultivation of human hepatocytes and non-parenchymal liver cells | Q42430038 | ||
| Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing | Q42496595 | ||
| Detection of statin cytotoxicity is increased in cells expressing the OATP1B1 transporter | Q42712029 | ||
| Long-term stability of primary rat hepatocytes in micropatterned cocultures | Q42713397 | ||
| Use of micropatterned cocultures to detect compounds that cause drug-induced liver injury in humans | Q42714258 | ||
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 15-25 | |
| P577 | publication date | 2017-12-29 | |
| P1433 | published in | Experimental Cell Research | Q1524289 |
| P1476 | title | Liver 'organ on a chip'. | |
| P478 | volume | 363 |
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