The N251K functional polymorphism in the alpha(2A)-adrenoceptor gene is not associated with depression: a study in suicide completers

scientific article published on 7 December 2005

The N251K functional polymorphism in the alpha(2A)-adrenoceptor gene is not associated with depression: a study in suicide completers is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00213-005-0266-2
P8608Fatcat IDrelease_jmfp4izqqfezzcdtegcudeqd2e
P698PubMed publication ID16333651

P50authorAfrica Garcia.OradQ69023729
J Javier MeanaQ40647219
Guadalupe RiveroQ47235613
P2093author name stringLuis F Callado
Idoia Martín-Guerrero
Koldo Saitua
P2860cites workIncreased alpha 2-adrenoceptor density in the frontal cortex of depressed suicide victimsQ69812240
Evaluation of studies on platelet alpha 2 adrenoreceptors in depressive illnessQ69889404
Polymorphism in the promoter region of the alpha(2A)-adrenergic receptor gene and panic disordersQ73502740
Unaltered alpha(2)-noradrenergic/imidazoline receptors in suicide victims: a postmortem brain autoradiographic analysisQ73934518
SuicideQ74535198
An asn to lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi couplingQ24290107
High activity-related allele of MAO-A gene associated with depressed suicide in malesQ28216609
Acute and chronic effects of desipramine and clorgyline on alpha(2)-adrenoceptors regulating noradrenergic transmission in the rat brain: a dual-probe microdialysis studyQ28345792
Chronic treatment with reboxetine by osmotic pumps facilitates its effect on extracellular noradrenaline and may desensitize alpha(2)-adrenoceptors in the prefrontal cortexQ28345858
Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victimsQ34357883
Identification and functional characterization of alpha(2)-adrenoceptor polymorphismsQ34360424
Pharmacology and physiology of human adrenergic receptor polymorphismsQ35050594
Subclassification of release-regulating alpha 2-autoreceptors in human brain cortexQ35871329
The platelet alpha 2-adrenoceptor as a potential biological marker in depressionQ38314329
TPH and suicidal behavior: a study in suicide completersQ43539801
Association analysis of polymorphism in the promoter region of the alpha2a-adrenoceptor gene with schizophrenia and clozapine responseQ43601604
Polymorphism in the promoter region of the alpha 2A adrenergic receptor gene and mood disordersQ43935987
Neurotransmitter receptor-mediated activation of G-proteins in brains of suicide victims with mood disorders: selective supersensitivity of alpha(2A)-adrenoceptors.Q44112148
Elevated agonist binding to alpha2-adrenoceptors in the locus coeruleus in major depressionQ44315062
Suicide and serotonin: study of variation at seven serotonin receptor genes in suicide completersQ44355996
Gene expression profiling of depression and suicide in human prefrontal cortexQ44645820
Regulation of platelet alpha 2A-adrenoceptors, Gi proteins and receptor kinases in major depression: effects of mirtazapine treatmentQ44662313
Alpha 2A adrenergic receptor gene and suicideQ44790127
Association between serotonin transporter gene promoter polymorphism and suicide: results of a meta-analysisQ44879403
Association between catechol-O-methyltransferase functional polymorphism and male suicide completersQ44883660
Characterization of noradrenaline release in the locus coeruleus of freely moving awake rats by in vivo microdialysis.Q45270552
Somatodendritic alpha2-adrenoceptors in the locus coeruleus are involved in the in vivo modulation of cortical noradrenaline release by the antidepressant desipramineQ47777731
Autoradiographic demonstration of increased alpha 2-adrenoceptor agonist binding sites in the hippocampus and frontal cortex of depressed suicide victims.Q48101263
Brain noradrenergic receptors in major depression and schizophreniaQ48179741
Electrophysiologic evidence for desensitization of alpha 2-adrenoceptors on serotonin terminals following long-term treatment with drugs increasing norepinephrine synaptic concentrationQ48180138
Endogenous noradrenaline activates alpha 2-adrenoceptors on serotonergic nerve endings in human and rat neocortex.Q48236969
Up-regulation of immunolabeled alpha2A-adrenoceptors, Gi coupling proteins, and regulatory receptor kinases in the prefrontal cortex of depressed suicidesQ48307823
Selective increase of alpha2A-adrenoceptor agonist binding sites in brains of depressed suicide victims.Q48518969
Alpha 2-adrenoceptors in the brain of suicide victims: increased receptor density associated with major depressionQ48522813
Brain alpha-adrenoceptors in depressed suicidesQ48706127
No influence of adrenergic receptor polymorphisms on schizophrenia and antipsychotic responseQ56447099
P433issue1
P304page(s)82-86
P577publication date2005-12-07
P1433published inPsychopharmacologyQ1422802
P1476titleThe N251K functional polymorphism in the alpha(2A)-adrenoceptor gene is not associated with depression: a study in suicide completers
P478volume184

Reverse relations

cites work (P2860)
Q39894765Alpha2C-adrenoceptor Del322-325 polymorphism and risk of psychiatric disorders: significant association with opiate abuse and dependence
Q38245264An overview of the neurobiology of suicidal behaviors as one meta-system.
Q34578414G protein-coupled receptors in major psychiatric disorders
Q28074917Genetic Association Studies of Suicidal Behavior: A Review of the Past 10 Years, Progress, Limitations, and Future Directions
Q37148543Stress, genes and the biology of suicidal behavior
Q34470397The neurobiology of suicide - A Review of post-mortem studies
Q36583816α2-Adrenoceptor Functionality in Postmortem Frontal Cortex of Depressed Suicide Victims

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